A5100617687- Cancer-related Molecular Pathways
- Nitric Oxide and Endothelin Effects
- Colorectal Cancer Treatments and Studies
- Alzheimer's disease research and treatments
- Cancer, Hypoxia, and Metabolism
- Ultrasound and Hyperthermia Applications
- Chemotherapy-induced cardiotoxicity and mitigation
- Neuroscience and Neuropharmacology Research
- Neurological Disease Mechanisms and Treatments
- Metabolism, Diabetes, and Cancer
- Ion Channels and Receptors
- Cardiovascular Function and Risk Factors
- RNA modifications and cancer
- Advanced Breast Cancer Therapies
- Neurological Disorders and Treatments
- Pancreatic function and diabetes
- Microtubule and mitosis dynamics
- Neuroinflammation and Neurodegeneration Mechanisms
- Nuclear Receptors and Signaling
- Antioxidant Activity and Oxidative Stress
- Circular RNAs in diseases
- Sphingolipid Metabolism and Signaling
- Peroxisome Proliferator-Activated Receptors
- Eicosanoids and Hypertension Pharmacology
- Selenium in Biological Systems
Xinxiang Medical University
2016-2025
Jisc
2024
Xinxiang University
2022
Huazhong University of Science and Technology
2016-2017
Xi'an University of Finance and Economics
2017
Central South University
2015-2016
Shandong University
2016
Hubei University of Science and Technology
2016
Jilin University
2016
Intracellular accumulation of wild-type tau is a hallmark sporadic Alzheimer's disease (AD), but the molecular mechanisms underlying tau-induced synapse impairment and memory deficit are poorly understood. Here we found that overexpression human full-length (termed hTau) induced deficits with impairments synaptic plasticity. Both in vivo vitro data demonstrated hTau caused remarkable dephosphorylation cAMP response element binding protein (CREB) nuclear fraction. Simultaneously,...
GTP cyclohydrolase 1 (GCH1) deficiency is critical for endothelial nitric oxide synthase uncoupling in dysfunction. MicroRNAs (miRs) are a class of regulatory RNAs that negatively regulate gene expression. We investigated whether statins prevent dysfunction via miR-dependent GCH1 upregulation.Endothelial function was assessed by measuring acetylcholine-induced vasorelaxation the organ chamber. MiR-133a expression quantitative reverse transcription polymerase chain reaction and fluorescence...
Accumulating epidemiological evidence supports that chronic exposure to ambient fine particular matters of <2.5 m (PM2.5) predisposes both children and adults Alzheimer's disease (AD) age-related brain damage leading dementia. There is also experimental show PM2.5 results in early onset AD-related pathologies transgenic AD mice development healthy rodents. Studies have documented causes AD-linked molecular cellular alterations, such as mitochondrial dysfunction, synaptic deficits, impaired...
Abstract To explore whether rosiglitazone (RSG), a selective peroxisome proliferator‐activated receptor γ (PPARγ) agonist, exerts beneficial effects on endothelial dysfunction induced by homocysteine thiolactone (HTL) and to investigate the potential mechanisms. Incubation of cultured human umbilical vein cells with HTL (1 mM) for 24 hrs significantly reduced cell viabilities assayed 3‐(4,5‐dimethyl‐2‐thiazolyl)‐2,5‐diphenyl‐2‐H‐tetrazolium bromide, as well enhanced productions reactive...
Patients with Alzheimer's disease (AD) commonly show anxiety behaviors, but the molecular mechanisms are not clear and no efficient intervention exists. Here, we found that overexpression of human wild-type, full-length tau (termed htau) in hippocampus significantly decreased extracellular γ-aminobutyric acid (GABA) level inhibition γ oscillation evoked inhibitory postsynaptic potential (eIPSP). With accumulation, mice age-dependent behaviors. Among factors responsible for GABA synthesis,...
Berberine has several preventive effects on cardiovascular diseases. Increased expression of miR-29b been reported to attenuate cardiac remodeling after myocardial infarction (MI). We hypothesized that berberine via an miR-29b-dependent mechanism promotes angiogenesis and improves heart functions in mice MI.The MI model was established by ligation left anterior descending coronary artery. The examined RT-qPCR. Angiogenesis assessed immunohistochemistry.Berberine increased promoted cell...
Pulmonary arterial hypertension (PAH) is characterized by the apoptosis resistance and hyperproliferation of pulmonary artery smooth muscle cells (PASMCs). Its pathogenesis has not been revealed. Here, we carried out experiments to investigate functions miR-140-5p tumor necrosis factor-α (TNF-α).We selected GSE703 from Gene Expression Omnibus (GEO) Database conduct microarray analysis using R software Set Enrichment Analysis (GSEA). Combing bioinformatics results, upregulation inhibited PAH...
Background: Vascular cognitive dysfunction in patients with vascular dementia(VD) is a serious syndrome caused by cerebrovascular diseases. At present, effective drugs to improve the function of VD still need be explored. KCNT specific potassium ion channel, which widely expressed brain. The increase NR1D1 contributes neuronal protection. Perillaldehyde (PAE) has protective effects on central nervous system diseases such as epilepsy and insomnia. Purpose:The purpose this study explore...
[This retracts the article DOI: 10.3892/etm.2015.2774.].
// Fu Wang 1 , Hui Ma Wen-Jing Liang Jing-Jing Yang Xue-Qing Mei-Rong Shan Yuan Chen Min Jia 2 Ya-Ling Yin 3 Xue-Ying Sun 4 Jia-Ning Zhang 5 Qi-Sheng Peng 6 Yu-Guo Li-Ying Liu Li Tao Guo and Shuang-Xi The Key Laboratory of Cardiovascular Remodeling Function Research, Qilu Hospital, Shandong University School Medicine, Jinan, China Department Rehabilitation Jinan Municipal Hospital Traditional Chinese Pharmacology, College Pharmacy, Xinxiang Medical University, Xinxiang, Pharmaceutical...
Glioma is one of the most common primary brain tumors. Gambogic acid (GA) widely used in tumor chemotherapy. However, GA has poor water solubility, low bioavailability, and difficult permeability across blood-brain barrier (BBB), leading to efficacy against In our study, we developed negatively charged GA-loaded PLGA nanobubbles [GA/poly(lactic-co-glycolic acid) (PLGA)] conjugated them onto surface cationic lipid microbubbles (CMBs) through electrostatic interactions. The resulting...
Epigallocatechin-3-gallate (EGCG) has a good therapeutic effect on type 2 diabetes mellitus (T2DM). This work was designed to explore EGCG's effectiveness in insulin resistance (IR) and pancreas islet β-cell function rat model of T2DM.Eight-week-old male Sprague Dawley rats were randomly divided into 6 groups, including the Control (normal diet), Diabetes (high-sucrose high-fat [HSHF] diet combined with tail vein injection streptozotocin [STZ] for T2DM induction) Treatment Diabetic which...
Abstract Cholinergic impairments and tau accumulation are hallmark pathologies in sporadic Alzheimer’s disease (AD), however, the intrinsic link between cholinergic deficits is missing. Here, we found that overexpression of human wild-type full-length (termed hTau) induced a significant reduction α4 subunit nicotinic acetylcholine receptors (nAChRs) with an increased cleavage receptor producing ~55kDa fragment primary hippocampal neurons rat brains, meanwhile, nAChR currents decreased....