A5009336243- Molecular Sensors and Ion Detection
- Retinoids in leukemia and cellular processes
- Cancer-related molecular mechanisms research
- Cerebrovascular and Carotid Artery Diseases
- MicroRNA in disease regulation
- Nitric Oxide and Endothelin Effects
- Ferroptosis and cancer prognosis
- Traditional Chinese Medicine Analysis
- Cancer, Hypoxia, and Metabolism
- Remote-Sensing Image Classification
- Circular RNAs in diseases
- Sulfur Compounds in Biology
- Metabolism, Diabetes, and Cancer
- Osteoarthritis Treatment and Mechanisms
- Magnolia and Illicium research
- Hippo pathway signaling and YAP/TAZ
- Neuroscience of respiration and sleep
- Peroxisome Proliferator-Activated Receptors
- Advanced Breast Cancer Therapies
- Image Retrieval and Classification Techniques
- Medicinal Plants and Bioactive Compounds
- Generative Adversarial Networks and Image Synthesis
- Synthesis and Characterization of Heterocyclic Compounds
- Prostate Cancer Treatment and Research
- Ginseng Biological Effects and Applications
Shanxi Medical University
2022-2025
Shaanxi Provincial People's Hospital
2025
Shaanxi Provincial People's Hospital
2025
North China University of Science and Technology
2024-2025
China Agricultural University
2024
Zhejiang Sci-Tech University
2023-2024
Xinxiang Medical University
2022-2024
Second Affiliated Hospital of Xi'an Jiaotong University
2017-2024
Shanghai University of Political Science and Law
2024
Online Technologies (United States)
2023
Deep neural networks (DNNs) are vulnerable to adversarial examples where inputs with imperceptible perturbations mislead DNNs incorrect results. Recently, patch, noise confined a small and localized emerged for its easy accessibility in real-world. However, existing attack strategies still far from generating visually natural patches strong attacking ability, since they often ignore the perceptual sensitivity of attacked network including both correlations image context visual attention. To...
Rice blast caused by Magnaporthe oryzae is one of the most destructive diseases and poses a growing threat to food security worldwide. Like many other filamentous pathogens, rice fungus releases multiple types effector proteins facilitate fungal infection modulate host defence responses. However, characterized effectors contain an N-terminal signal peptide. Here, we report results functional characterization nonclassically secreted nuclear targeting in M. (MoNte1). MoNte1 has no peptide, but...
Abstract Objectives Life's essential 8 (LE8) is an emerging approach for accessing and quantifying cardiovascular health (CVH), but the effect on Parkinson's disease (PD) still unclear. This study aimed to elucidate association between LE8 metrics PD in US adults. Methods Data of 26,975 participants were extracted from last 7 National Health Nutrition Examination Survey (NHANES) cycles (2005–2018). The calculated according American Heart Association criterion, divided into 3 groups using...
Homer1 interacts with calcium-sensing receptors (CaSRs) in osteoblasts (OBs), both CaSR and playing essential roles AKT phosphorylation. This study investigated the impact of on expression during differentiation rat bone marrow mesenchymal stem cells (BMSCs) at morphological, imaging, molecular levels, vivo vitro. A post-oophorectomy osteoporosis model was established Sprague-Dawley rats, validated through micro-computed tomography, hematoxylin-eosin staining, biomechanical testing to assess...
Background Observational studies indicate a complex relationship between coagulation factors and Alzheimer's disease (AD). However, the current findings are inconsistent, it remains uncertain whether causal exists. Objective This study utilizes Mendelian randomization analysis to investigate relationships blood levels of AD risk. Methods Eleven with valid instrumental variables available were evaluated. Two independent cohorts European ancestry genome-wide association (GWAS) summary...
Circular RNAs (circRNAs) play a crucial role in gene expression regulation. CircHIPK3 is circRNA derived from Exon 2 of HIPK3 and its prostate cancer (PCa) still unclear. CCK8 assays, flow cytometry colony formation assays were performed to assess the effects circHIPK3 PCa cells. Bioinformatics analysis, RNA pull-down assay, immunoprecipitation assay (RIP), luciferase activity dissect mechanism underlying circHIPK3-mediated G2/M transition was upregulated cells tissues. Overexpression or...
Oxidative stress (OS) irreversibly affects the pathogenesis of intervertebral disc degeneration (IDD). Certain non-coding RNAs act as competitive endogenous (ceRNAs) that regulate IDD progression. Analyzing signatures oxidative stress-related gene (OSRG) pairs and regulatory ceRNA mechanisms immune-infiltration patterns associated with may enable researchers to distinguish reveal underlying mechanisms. In this study, OSRGs were downloaded identified using Gene Expression Omnibus database....
Pyroptosis is an inflammatory form of programmed cell death triggered by caspase-1/4/5/11 that plays important role in the occurrence and development gastric cancer (GC). We investigated prognostic value pyroptosis-related genes GC. The “LIMMA” R package univariate Cox analysis were used to find with differential expression TCGA cohort identified analyzed for GO enrichment KEGG pathways. selected then included a multivariate proportional hazard regression analysis, ten model (BIRC2, CD274,...
Ischemic stroke (IS) is a principal contributor to long-term disability in adults. A new cell death mediated by iron ferroptosis, characterized lethal aggregation of lipid peroxidation. However, paucity ferroptosis-related biomarkers early identify IS until now. This study investigated potential gene pair and explored their roles immune infiltration.In total, we identified 6 differentially expressed genes (DEFRGs) the metadata cohort. Of these genes, 4 DEFRGs were incorporated into...
Abstract Osteoarthritis (OA) is a chronic degenerative disease characterized by overall joint tissue damage. Metformin (Met) has been shown to inhibit inflammatory reactions, though its potential protective mechanism on cartilage remains unclear. This study investigated Met’s protect in an OA rat model. Various morphological experiments were conducted assess changes morphology before and after Met treatment. Protein mRNA levels of cartilage-specific genes measured using western blot,...
Abstract Background Screening carotid B-mode ultrasonography is a frequently used method to detect subjects with atherosclerosis (CAS). Due the asymptomatic progression of most CAS patients, early identification challenging for clinicians, and it may trigger ischemic stroke. Recently, machine learning has shown strong ability classify data potential prediction in medical field. The combined use electronic health records patients could provide clinicians more convenient precise identify CAS....
Oxidative stress (OS) and immune inflammation play complex intersections in the pathophysiology of ischemic stroke (IS). However, a competing endogenous RNA- (ceRNA-) based mechanism linked to IS has not been explored. We aimed identify potential OS-related signatures analyze infiltration characteristics IS. Three datasets (GSE22255, GSE110993, GSE140275) from GEO database were extracted. Differentially expressed long noncoding RNAs, microRNAs, messenger RNAs (DElncRNAs, DEmiRNAs, DEmRNAs)...
Abstract Background Individual colorectal polyp risk factors are well characterized; however, insights into their pathway-specific interactions scarce. We aimed to identify the impact of individual and joint effects on adenomatous (AP) serrated (SP) risk. Methods collected information 363 lifestyle metabolic parameters from 1597 colonoscopy participants, resulting in over 521,000 data points. used multivariate statistics machine-learning approaches assess associations single variables with...
The failure of androgen deprivation therapy in prostate cancer treatment mainly results from drug resistance to receptor antagonists. Although an aberrant caveolin‑1 (Cav‑1) expression has been reported multiple tumor cell lines, it is unknown whether responsible for the progression castration‑resistant (CRPC). Thus, aim present study was determine Cav‑1 can be used as a key molecule prevention and CRPC, explore its mechanism action CRPC. For this purpose, tissue serum samples patients with...
Metabolic rewiring is a common feature of many cancer types, including prostate (PCa). Alterations in master genes lead to mitochondrial metabolic and provide an appealing target inhibit progression improve survival. Phospholipase C (PLC)ε regulator tumor generation progression. However, its role metabolism remains unclear. The GEO, Cancer Genome Atlas, the GTEx databases were used determine Twist1 mRNA levels tumors their non-tumor counterparts. Fifty-five PCa 48 benign prostatic...
A new selenide-based fluorescent probe was developed for rapid and sensitive detection of HOCl in living cells zebrafish.
Low response, treatment-related complications and relapse due to the low sensitivity of myelodysplastic syndrome (MDS) leukemia stem cells (LSCs) or pre‑LSCs arsenic trioxide (ATO), represent main problems following treatment with ATO alone in patients MDS. To solve these problems, a chemosensitization agent can be applied increase susceptibility ATO. Curcumin (CUR), which possesses wide range anticancer activities, is commonly used for various types tumors, including hematopoietic...