A5100437833- Respiratory Support and Mechanisms
- Sulfur Compounds in Biology
- Sepsis Diagnosis and Treatment
- Endoplasmic Reticulum Stress and Disease
- Neonatal Respiratory Health Research
- Sirtuins and Resveratrol in Medicine
- Nanoplatforms for cancer theranostics
- Pharmacological Effects of Natural Compounds
- Airway Management and Intubation Techniques
- Biochemical effects in animals
- Erythropoietin and Anemia Treatment
- Ginkgo biloba and Cashew Applications
- Anesthesia and Neurotoxicity Research
- Chronic Myeloid Leukemia Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Nanoparticle-Based Drug Delivery
- Adipose Tissue and Metabolism
- Neuroinflammation and Neurodegeneration Mechanisms
- Cytokine Signaling Pathways and Interactions
- Thermal Regulation in Medicine
- Cancer Research and Treatments
- PARP inhibition in cancer therapy
- Ginseng Biological Effects and Applications
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Medicinal Plants and Bioactive Compounds
Chengdu Medical College
2025
Shanghai University of Traditional Chinese Medicine
2025
Second Hospital of Anhui Medical University
2024
Anhui Medical University
2024
Yunnan Agricultural University
2024
Huangshan University
2024
Anhui University
2023
Heilongjiang Bayi Agricultural University
2022
Feinstein Institute for Medical Research
2021-2022
Health Innovations (United States)
2021-2022
Acute lung injury (ALI) is characterized by pulmonary diffusion abnormalities that may progress to multiple-organ failure in severe cases. There are limited effective treatments for ALI, which makes the search new therapeutic avenues critically important. Macrophages play a pivotal role pathogenesis of ALI. The degree macrophage polarization closely related severity and prognosis S100A9 promotes M1 macrophages. present study assessed effects S100A9-gene deficiency on acute injury. Our cohort...
Fedratinib (SAR302503/TG101348) is a Janus kinase 2 (JAK2)-selective inhibitor in clinical development for the treatment of myelofibrosis. In this randomized, placebo-controlled, Phase 1 study, pharmacokinetics, pharmacodynamics and tolerability ascending single doses fedratinib (10–680 mg) were assessed healthy male subjects. was rapidly absorbed, with peak plasma concentration observed approximately 3 hours after dosing. The mean terminal half-life 67 hours, which unaffected by dose....
Atherosclerosis (AS) is a chronic progressive disease caused by various factors and causes cerebrovascular cardiovascular diseases (CVDs). Reducing the plasma levels of low-density lipoprotein cholesterol primary goal in preventing treating AS. Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays crucial role regulating metabolism. Panax notoginseng has potent lipid-reducing effects protects against CVDs, its saponins induce vascular dilatation, inhibit thrombus formation, are used...
Acute lung injury (ALI) is a serious disease with high incidence in ICU, and impaired mitochondria function plays significant role ALI. In this study, we examined the possible roles of exogenous hydrogen sulfide (H2S) regulation ALI rats. The rat model was induced by an intra-tongue vein Lipopolysaccharide (LPS) injection. We used sodium hydrosulphide (NaHS) as H2S donor. randomly divided 40 Sprague–Dawley rats into five groups: control, LPS injury, + low-dose NaHS (0.78 mg•kg-1),...
Abstract Background Understanding heterogeneity seen in patients with COVIDARDS and comparing to non-COVIDARDS may inform tailored treatments. Methods A multidisciplinary team of frontline clinicians data scientists worked create the Northwell dataset (NorthCARDS) leveraging over 11,542 COVID-19 hospital admissions. The was then summarized examine descriptive differences based on clinically meaningful categories lung compliance, trends oxygenation. Findings Of 1536 NorthCARDS dataset, there...
Ischemia reperfusion (I/R) injury remains a frequent adverse event that accompanies heart transplantation. Oxidative stress and aberrant production of free radicals were regarded as the culprit cell death tissue damage in post-transplant IR injury. Mst1 has been identified mediator oxidative Nrf2 regulates anti-oxidative enzymes, however, interaction between pathway to be clarified cardiac Herein, model ischemia-reperfusion heterotopic transplantation mice was firstly established.. We...
Abstract The study aimed to investigate the efficacy of PCV-VG combined with individual PEEP during laparoscopic surgery in Trendelenburg position. 120 patients were randomly divided into four groups: VF group (VCV plus 5cmH 2 O PEEP), PF (PCV-VG VI and PI PEEP). P mean , peak Cdyn, PaO /FiO V D /V T A-aDO Qs/Qt recorded at 1 (15 min after induction anesthesia), (60 pneumoperitoneum), 3 (5 end anesthesia). CC16 IL-6 measured . Our results showed that was increased group, lower At Cdyn higher...
Cold stress disturbs cellular metabolic and energy homeostasis, which is one of the causes stress-induced illnesses. O-GlcNAcylation a nutrient-sensing pathway involved in myriad processes. It plays key role homeostasis. Nevertheless, specific sensing mechanism linking skeletal muscle to cold unknown. In this study, SIRT1 was targeted explore adaptation stress. Ogt mKO aggravated fibrosis induced by At same time, gene deletion accelerated homeostasis imbalance oxidative mitochondria vitro...
Abstract Rationale The preliminary reports of COVID Acute Respiratory Distress Syndrome (COVIDARDS) suggest the existence a subset patients with higher lung compliance despite profound hypoxemia. Understanding heterogeneity seen in COVIDARDS and comparing to non-COVIDARDS may inform tailored treatments. Objectives To describe trajectories hypoxemia respiratory associations outcomes. Methods A multidisciplinary team frontline clinicians data scientists created Northwell dataset (NorthCARDS)...
// Jing Cheng 1 , Yanping Liu 1,2 Guishuang Li Zhongwen Zhang 3 Lianyue Ma Xiaoyan Yang Jianmin Kai Kong Mei Dong Meng Xingli Xu Wenhai Sui Jiali Wang Rui Shang Xiaoping Ji Yun and Panpan Hao The Key Laboratory of Cardiovascular Remodeling Function Research, Chinese Ministry Education Health, Shandong University Qilu Hospital, Jinan, Shandong, China 2 Cerebrovascular Disease, Provincial Medical Imaging Institute, University, Qianfoshan Correspondence to: Hao, email: Keywords : noninvasive...
To observe the effects of hydrogen sulfide (H2S) on structure and function mitochondria lung in rats with acute injury (ALI) induced by lipopolysaccharide (LPS).Forty healthy male Sprague-Dawley (SD) were randomly divided into control group, LPS low-, middle-, high-dose NaHS groups, 8 each group. The group given 5 mg/kg via sublingual vein, those groups challenged for 3 hours followed intraperitoneally injection 0.78, 1.56 3.12 respectively a volume 2 mL/kg. mL/kg normal saline vein....
Abstract Objective: O-GlcNAcylation, a nutrient sensing pathway involved in myriad of cellular processes, it plays key role metabolism homeostasis. Cold stress disturbs metabolic and energy homeostasis is one the causes stress-induced illnesses. It reported that O-GlcNAcylation has been shown to be upregulated during cold stress. Skeletal muscle its residential mitochondria play an important maintaining whole body. Nevertheless, mechanism which adapts skeletal remains unknown. Methods: To...
Objective To evaluate the effect of aminoguanidine on cell apoptosis induced by acute myocardial ischemia in rats.Methods Thirty adult male Sprague-Dawley rats,weighing 250-290 g,were randomly divided into 3 groups (n =10 each):sham operation group (group S),myocardial Ⅰ),and AG).The model was established ligating left anterior descending branch coronary artery rats anesthetized with chloral hydrate.Aminoguanidine 100 mg/kg intraperitoneally administrated at 6 h AG group,while equal volume...
Objective To evaluate the effect of exogenous hydrogen sulfide (H2S) on mitochondrion-dependent apoptosis in lung tissues rats with endotoxemia. Methods Forty healthy male Sprague-Dawley rats, aged 2-3 months, weighing 250-310 g, were divided into 5 groups (n=8 each) using a random number table: control group (group C), lipopolysaccharide (LPS) group, low dose sodium hydrosulphide (NaHS) L-NaHS), moderate NaHS M-NaHS) and high H-NaHS). Endotoxemia was induced by IV LPS mg/kg chloral...