A5079840891- Endoplasmic Reticulum Stress and Disease
- Adipose Tissue and Metabolism
- Sirtuins and Resveratrol in Medicine
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Biochemical effects in animals
- Neuroinflammation and Neurodegeneration Mechanisms
- Advanced Glycation End Products research
- Liver Disease Diagnosis and Treatment
- Power Systems and Renewable Energy
- RNA modifications and cancer
- Extracellular vesicles in disease
- Cannabis and Cannabinoid Research
- Cancer-related gene regulation
- Reproductive System and Pregnancy
- Epigenetics and DNA Methylation
- Adenosine and Purinergic Signaling
- Autophagy in Disease and Therapy
- Cancer-related molecular mechanisms research
- Liver Disease and Transplantation
- Developmental Biology and Gene Regulation
- Genetics, Aging, and Longevity in Model Organisms
- RNA Research and Splicing
- Genetic Syndromes and Imprinting
- Heme Oxygenase-1 and Carbon Monoxide
Heilongjiang Bayi Agricultural University
2020-2024
Jiangsu University
2024
Zhenjiang City Fourth People's Hospital
2024
Affiliated Hospital of Jiangsu University
2024
Abstract Background Premature ovarian insufficiency (POI) is an important cause of female infertility and seriously impacts the physical psychological health patients. Human umbilical cord mesenchymal stem cell-derived exosomes (HucMSCs-Exs, H-Exs) have exhibited protective effects on function with unclear mechanisms. Methods A comprehensive analysis Gene Expression Omnibus (GEO) database were used to identify POI-associated circRNAs miRNAs. The relationship between HucMSC-derived exosomal...
Abstract Cold is a factor affecting health in humans and animals. The liver, major metabolic center, highly susceptible to ambient air temperature. Recent studies have shown that endoplasmic reticulum (ER) stress associated with the regulates occurrence development of liver injury autophagy. However, mechanism underlying relationship between cold exposure ER not well understood. In this study, we investigated effect on autophagy its under exposure. AML12 cells were treated Tg construct an...
Ambient air temperature is a key factor affecting human health. Long-term exposure to cold environment can cause various diseases, while the impact on intestine, organ which has largest contact area with external environment, cannot be ignored. In this study, we investigated effect of chronic colon and its preliminary mechanism action. Mice were exposed 4°C for 3 hours day 10 days. We found that damaged morphology structure colon, destroyed tight junctions colonic epithelial tissue, promoted...
Abstract Procyanidin B2 (PB2), a naturally occurring flavonoid abundant in wide range of fruits, has been shown to exert antioxidant, anti‐inflammatory and anticancer properties. However, the role PB2 prevention cold stimulation (CS)‐induced liver injury. The present study was undertaken determine effects on injury induced by its potential molecular mechanisms. results showed that treatment with significantly reduced CS‐induced alleviating histopathological changes serum levels alanine...
The main danger of cold stress to animals in regions is systemic metabolic changes and protein synthesis inhibition. Cold-induced RNA-binding a shock that rapidly up-regulated under stimulation contrast the inhibition most proteins participates multiple cellular physiological activities by regulating targets. Therefore, this study was carried out investigate possible mechanism CIRP-mediated glucose metabolism regulation survival promotion skeletal muscle after acute exposure. Skeletal serum...
High mobility group protein B1 (HMGB1) acts as a pathogenic inflammatory response to mediate ranges of conditions such epilepsy, septic shock, ischemia, traumatic brain injury, Parkinson's disease, Alzheimer's disease and mass spectrometry. HMGB1 promotes inflammation during sterile infectious damage plays crucial role in development. Mobilization from the nucleus cytoplasm is first important step release activated immune cells. Here, we demonstrated that Sirtuin 2 (SIRT2) physically...
Cold stress disturbs cellular metabolic and energy homeostasis, which is one of the causes stress-induced illnesses. O-GlcNAcylation a nutrient-sensing pathway involved in myriad processes. It plays key role homeostasis. Nevertheless, specific sensing mechanism linking skeletal muscle to cold unknown. In this study, SIRT1 was targeted explore adaptation stress. Ogt mKO aggravated fibrosis induced by At same time, gene deletion accelerated homeostasis imbalance oxidative mitochondria vitro...
miRNAs are a class of small non-coding RNAs that involved in various biological processes. In the preliminary work laboratory, found miR-383-5p was down-regulated liver tissue acute cold stress rats and has been shown to be an important regulatory factor tumour proliferation, but there very few studies involving mediation rat tissues. Therefore, purpose this study determine effect on livers by simulating state tissues vitro using H2 O2 induce hepatocyte oxidative stress. The results showed...
Abstract Background: Premature ovarian insufficiency (POI) is an important cause of female infertility and seriously impacts the physical psychological health patients. Human umbilical cord mesenchymal stem cell-derived exosomes (HucMSCs-Exs, H-Exs) have exhibited protective effects on function with unclear mechanisms. Methods: A comprehensive analysis Gene Expression Omnibus (GEO) database were used to identify POI-associated circRNAs miRNAs. The relationship between HucMSC-derived exosomal...
Cold exposure exerts negative effects on hippocampal nerve development in adolescent mice, but the underlying mechanisms are not fully understood. Given that ubiquitination is essential for neurodevelopmental processes, we attempted to investigate of cold hippocampus from perspective ubiquitination. By conducting a ubiquitinome analysis, found caused changes levels variety synaptic-associated proteins. We validated postsynaptic density-95 (PSD-95) by immunoprecipitation, revealing reductions...
<title>Abstract</title> <bold>Objective:</bold> Chemotherapy resistance remains a barrier to improving the prognosis of epithelial ovarian cancer (EOC), and among several novel approaches overcome chemotherapy resistance, modulating N6- methyladenosine (m6A) RNA modification was found be an important strategy. However, mechanism m6A regulator genes in EOC has not been fully elucidated. <bold>Methods:</bold> We out target through bioinformatics verified them cell biology experiments, animal...
Short-term load forecasting is an essential foundation for the optimization and economic operation of microgrids. In response to impacts seasonal, periodic, random fluctuations in original microgrid data on accuracy, this paper proposes a short-term model microgrids based Complete Ensemble Empirical Mode Decomposition with Adaptive Noise (CEEMDAN) Long Short-Term Memory Neural Network (LSTM). First, CEEMDAN method employed decompose sequence into several sub-sequences different frequencies...
Abstract Objective: O-GlcNAcylation, a nutrient sensing pathway involved in myriad of cellular processes, it plays key role metabolism homeostasis. Cold stress disturbs metabolic and energy homeostasis is one the causes stress-induced illnesses. It reported that O-GlcNAcylation has been shown to be upregulated during cold stress. Skeletal muscle its residential mitochondria play an important maintaining whole body. Nevertheless, mechanism which adapts skeletal remains unknown. Methods: To...
Abstract Liver fibrosis is a crucial step in the progression of various chronic liver diseases to cirrhosis, which can affect prognosis diseases. The NAD + dependent deacetylase sirtuins family member SIRT2 regulate inflammatory corpuscular pathway pathological processes, but its related mechanism not yet clear. This study established models wild-type and knockout mice, evaluated their effects on homeostasis using immunoblotting, immunofluorescence, histopathological staining methods....
Abstract Background It is widely accepted that high mobility group box 1 (HMGB1) a key inflammatory mediator in the pathogenesis of sepsis. HMGB1 promotes inflammation during sterile and infectious damage plays crucial role disease development. Mobilization from nucleus to cytoplasm first important step release activated immune cells. Sirtuin 2 (SIRT2) member sirtuin family, nicotinamide adenine dinucleotide+-dependent deacylases, which participates modulation cell cycle control...