A5101886571- Sirtuins and Resveratrol in Medicine
- Ruminant Nutrition and Digestive Physiology
- Endoplasmic Reticulum Stress and Disease
- Reproductive Physiology in Livestock
- Paraoxonase enzyme and polymorphisms
- Adipose Tissue and Metabolism
- Genetic and phenotypic traits in livestock
- Asthma and respiratory diseases
- Ion channel regulation and function
- Neuroscience of respiration and sleep
- Autophagy in Disease and Therapy
- Heat shock proteins research
- Biochemical effects in animals
- Glycosylation and Glycoproteins Research
- Birth, Development, and Health
- Insects and Parasite Interactions
- Parasite Biology and Host Interactions
- Study of Mite Species
- Exercise and Physiological Responses
- Hibiscus Plant Research Studies
- Carbohydrate Chemistry and Synthesis
- Genetic Mapping and Diversity in Plants and Animals
- Sulfur Compounds in Biology
- Physiological and biochemical adaptations
- Genetic Neurodegenerative Diseases
Heilongjiang Bayi Agricultural University
2016-2025
Heilongjiang Provincial Academy of Agricultural Sciences
2024-2025
Wenzhou University
2024
Baylor College of Medicine
2008
China Medical University
2007
Abstract Nonalcoholic fatty liver disease (NAFLD) has become one of the most common chronic diseases. O‐Linked attachment beta‐N‐acetylglucosamine ( O ‐GlcNAc) are ubiquitous post‐translational modifications proteins as “nutrient sensors” and “stress receptors” in body that involved maintaining normal cellular physiological functions. Increased levels ‐GlcNAcylation have been found samples patients with NAFLD nonalcoholic steatohepatitis. However, role development pathogenesis remains...
Metabolic profiling was performed using nuclear magnetic resonance (NMR)-based metabolomics to explore panoramic changes in ketosis metabolism dairy cows, and further understand metabolites when occurred. According clinical signs plasma levels, 81 multiparous Holstein cows from a farm were divided into ketosis, subclinical healthy control groups during 7–21 d after calving. Different identified by NMR combined with multivariate statistical analysis determine the pathway. There 29 obtained,...
Abstract Introduction: The predictive value of selected parameters in the risk ketosis and fatty liver dairy cows was determined. Material Methods: In total, 21 control 17 ketotic Holstein Friesian with a β-hydroxybutyrate (BHBA) concentration 1.20 mmol/L as cut-off point were selected. prediction thresholds for determined by receiver operating characteristic (ROC) curve analysis. Results: group, paraoxonase-1 (PON-1) activity PON-1 glucose (GLU) decreased, aminotransferase (AST) well BHBA...
The main danger of cold stress to animals in regions is systemic metabolic changes and protein synthesis inhibition. Cold-induced RNA-binding a shock that rapidly up-regulated under stimulation contrast the inhibition most proteins participates multiple cellular physiological activities by regulating targets. Therefore, this study was carried out investigate possible mechanism CIRP-mediated glucose metabolism regulation survival promotion skeletal muscle after acute exposure. Skeletal serum...
Cold stress disturbs cellular metabolic and energy homeostasis, which is one of the causes stress-induced illnesses. O-GlcNAcylation a nutrient-sensing pathway involved in myriad processes. It plays key role homeostasis. Nevertheless, specific sensing mechanism linking skeletal muscle to cold unknown. In this study, SIRT1 was targeted explore adaptation stress. Ogt mKO aggravated fibrosis induced by At same time, gene deletion accelerated homeostasis imbalance oxidative mitochondria vitro...
Abstract Introduction: A model of fatty liver in postpartum sheep was established to measure blood paraoxonase 1 (PON1) and other biochemical indicators, which were used predict sheep. Material Methods: Sheep assigned into two experimental groups: a group (T, n = 10) healthy control (C, 5). PON1 enzyme activity towards paraoxon as substrate quantified spectrophotometrically. The results analysed by t -test pearson correlation coefficient. Disease predicted binary logistic analysis,...
Abstract Introduction: To identify novel pathways involved in the pathogenesis of ketosis, an isobaric tag for relative and absolute quantitation/mass spectrometry was used to define differences protein expression profiles between healthy dairy cows those with clinical or subclinical ketosis. Material Methods: ketosis cattle, were analysed by bioinformatics. Go Ontology Pathway analysis carried out enrich role pathway different proteins Results: Differences identified 19 proteins, 16 which...
Species of the family Prosthogonimidae are considered most pathogenic trematodes poultry and wild birds worldwide, causing heavy economic losses in many countries. Prosthogonimosis was a common parasitic disease
Abstract Objective: O-GlcNAcylation, a nutrient sensing pathway involved in myriad of cellular processes, it plays key role metabolism homeostasis. Cold stress disturbs metabolic and energy homeostasis is one the causes stress-induced illnesses. It reported that O-GlcNAcylation has been shown to be upregulated during cold stress. Skeletal muscle its residential mitochondria play an important maintaining whole body. Nevertheless, mechanism which adapts skeletal remains unknown. Methods: To...
Abstract Background The effect of cold stress on skeletal muscle metabolism is not clear, and O-linked-N-acetylglucosaminylation(O-GlcNAcylation) important for energy homeostasis. So, we aimed to clarify the functional role O-GlcNAcylation in during stress. Results To understand muscle, ablated OGT thus specifically mouse subjected mice Cold induced profound damages reduced content mitochondria, compromised mitochondrial functions. In response stress, pathways involved autophagy mitophagy...