A5008097843- Endoplasmic Reticulum Stress and Disease
- Sirtuins and Resveratrol in Medicine
- Biochemical effects in animals
- Carbohydrate Chemistry and Synthesis
- Glycosylation and Glycoproteins Research
- Autophagy in Disease and Therapy
- Galectins and Cancer Biology
Heilongjiang Bayi Agricultural University
2022-2025
Abstract Nonalcoholic fatty liver disease (NAFLD) has become one of the most common chronic diseases. O‐Linked attachment beta‐N‐acetylglucosamine ( O ‐GlcNAc) are ubiquitous post‐translational modifications proteins as “nutrient sensors” and “stress receptors” in body that involved maintaining normal cellular physiological functions. Increased levels ‐GlcNAcylation have been found samples patients with NAFLD nonalcoholic steatohepatitis. However, role development pathogenesis remains...
Abstract Objective: O-GlcNAcylation, a nutrient sensing pathway involved in myriad of cellular processes, it plays key role metabolism homeostasis. Cold stress disturbs metabolic and energy homeostasis is one the causes stress-induced illnesses. It reported that O-GlcNAcylation has been shown to be upregulated during cold stress. Skeletal muscle its residential mitochondria play an important maintaining whole body. Nevertheless, mechanism which adapts skeletal remains unknown. Methods: To...
Abstract Background The effect of cold stress on skeletal muscle metabolism is not clear, and O-linked-N-acetylglucosaminylation(O-GlcNAcylation) important for energy homeostasis. So, we aimed to clarify the functional role O-GlcNAcylation in during stress. Results To understand muscle, ablated OGT thus specifically mouse subjected mice Cold induced profound damages reduced content mitochondria, compromised mitochondrial functions. In response stress, pathways involved autophagy mitophagy...