A5046376178- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- RNA modifications and cancer
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Reproductive System and Pregnancy
- Ubiquitin and proteasome pathways
- Cancer-related gene regulation
- Pregnancy and preeclampsia studies
- DNA Repair Mechanisms
- Mitochondrial Function and Pathology
- ATP Synthase and ATPases Research
- interferon and immune responses
- Ferroptosis and cancer prognosis
- RNA Research and Splicing
- Protein Degradation and Inhibitors
- Endometriosis Research and Treatment
- Histone Deacetylase Inhibitors Research
- Cancer, Hypoxia, and Metabolism
Jiangsu University
2021-2025
Affiliated Hospital of Jiangsu University
2022-2025
Zhenjiang City Fourth People's Hospital
2023-2024
Guiyang Medical University
2024
Affiliated Hospital of Guizhou Medical University
2024
Guangxi Medical University
2024
Chemoresistance is a severe outcome among patients with epithelial ovarian cancer (EOC) that leads to poor prognosis. YBX-1 has been shown cause treatment failure and progression in EOC. However, strategies directly target are not yet conceivable. Here, we identified SIAH1 which was downregulated chemoresistant EOC samples cell lines functioned as novel E3 ligases trigger degradation of at cytoplasm by RING finger domain. Mechanistic studies show ubiquitinated lys304 lead the instability its...
Abstract Premature ovarian failure (POF) is an important cause of female infertility and seriously impacts the physical psychological health patients. Mesenchymal stromal cells-derived exosomes (MSCs-Exos) have essential role in treatment reproductive disorders, particularly POF. However, biological function therapeutic mechanism MSCs exosomal circRNAs POF remain to be determined. Here, with bioinformatics analysis functional assays, circLRRC8A was found downregulated senescent granulosa...
Abstract Background Premature ovarian insufficiency (POI) is an important cause of female infertility and seriously impacts the physical psychological health patients. Human umbilical cord mesenchymal stem cell-derived exosomes (HucMSCs-Exs, H-Exs) have exhibited protective effects on function with unclear mechanisms. Methods A comprehensive analysis Gene Expression Omnibus (GEO) database were used to identify POI-associated circRNAs miRNAs. The relationship between HucMSC-derived exosomal...
Abstract Tumor-associated lncRNAs regulated by epigenetic modification switches mediate immune escape and chemoresistance in ovarian cancer (OC). However, the underlying mechanisms concrete targets have not been systematically elucidated. Here, we discovered that methylation modifications played a significant role regulating cell infiltration sensitizing OC to chemotherapy modulating immune-related (irlncRNAs), which represent tumor status. Through deep analysis of TCGA database, prognostic...
Recently, interest in investigating the effects of long noncoding RNAs (lncRNAs) on endometrial receptivity (ER) has increased within field assisted reproductive technology. Therefore, objective this study is to identify and analyze role lncRNA LUCAT1 elucidate its specific mechanism regulating ER. Hub genes associated with ER are identified via Weighted gene co-expression network analysis (WGCNA) two datasets downloaded from GEO database. These hub WGCNA were subsequently validated. The...
Abstract Premature ovarian failure (POF) affects many adult women less than 40 years of age and leads to infertility. Mesenchymal stem cells-derived small extracellular vesicles (MSCs-sEVs) are attractive candidates for function restoration folliculogenesis POF due their safety efficacy, however, the key mediator in MSCs-sEVs that modulates this response underlying mechanisms remains elusive. Herein, we reported YB-1 protein was markedly downregulated vitro vivo models induced with H 2 O CTX...
The E3 ligase SIAH1 is deregulated in human cancers and correlated with poor prognosis, but its contributions to chemoresistance epithelial ovarian cancer (EOC) are not evident. Herein we found that was decreased EOC tumour tissues cell lines negatively the RPS3 levels. overexpression suppressed growth, colony formation, invasion, metastasis, cisplatin resistance vivo vitro. promoted ubiquitination degradation using RING-finger domain, these steps were required for localization cytoplasm,...
Abstract Background: Premature ovarian insufficiency (POI) is an important cause of female infertility and seriously impacts the physical psychological health patients. Human umbilical cord mesenchymal stem cell-derived exosomes (HucMSCs-Exs, H-Exs) have exhibited protective effects on function with unclear mechanisms. Methods: A comprehensive analysis Gene Expression Omnibus (GEO) database were used to identify POI-associated circRNAs miRNAs. The relationship between HucMSC-derived exosomal...
<title>Abstract</title> <bold>Objective:</bold> Chemotherapy resistance remains a barrier to improving the prognosis of epithelial ovarian cancer (EOC), and among several novel approaches overcome chemotherapy resistance, modulating N6- methyladenosine (m6A) RNA modification was found be an important strategy. However, mechanism m6A regulator genes in EOC has not been fully elucidated. <bold>Methods:</bold> We out target through bioinformatics verified them cell biology experiments, animal...
The E3 ligase SIAH1 is deregulated in human cancers and correlated with poor prognosis, but its contributions to chemoresistance epithelial ovarian cancer (EOC) are not evident. Herein we show that decreased EOC tumour tissues cell lines negatively RPS3 level. overexpression suppresses growth, colony formation, invasion, metastasis, cisplatin resistance vivo vitro. promoted ubiquitination degradation using the RING-finger domain, which was required for localization cytoplasm subsequent NF-κB...