A5101702656- Cancer, Hypoxia, and Metabolism
- Prostate Cancer Treatment and Research
- Cancer-related gene regulation
- Microbial metabolism and enzyme function
- RNA modifications and cancer
- Cancer, Lipids, and Metabolism
- Epigenetics and DNA Methylation
- Angiogenesis and VEGF in Cancer
- Chemotherapy-induced cardiotoxicity and mitigation
- Ubiquitin and proteasome pathways
- Endometriosis Research and Treatment
- Ovarian function and disorders
- Mechanisms of cancer metastasis
- GDF15 and Related Biomarkers
- Infectious Disease Case Reports and Treatments
- Ovarian cancer diagnosis and treatment
- Colorectal and Anal Carcinomas
- Endometrial and Cervical Cancer Treatments
- Cardiac tumors and thrombi
- Multiple Myeloma Research and Treatments
- Pneumonia and Respiratory Infections
- Pulmonary Hypertension Research and Treatments
- Reproductive System and Pregnancy
- Sarcoma Diagnosis and Treatment
- Antibiotics Pharmacokinetics and Efficacy
Jiangsu University
2021-2023
Affiliated Hospital of Guizhou Medical University
2023
Guiyang Medical University
2023
Weatherford College
2022
Shandong First Medical University
2020
Zhangqiu City People's Hospital
2018
Peking University Cancer Hospital
2016
Johns Hopkins Medicine
2012-2013
Johns Hopkins University
2012-2013
Physical Sciences (United States)
2013
Abstract The presence of hypoxia and fibrosis within the primary tumor are two major risk factors for metastasis human breast cancer. In this study, we demonstrate that hypoxia-inducible factor 1 activates transcription genes encoding collagen prolyl hydroxylases critical deposition by cancer cells. We show expression promotes cell alignment along fibers, resulting in enhanced invasion to lymph nodes lungs. Finally, establish prognostic significance hydroxylase mRNA biopsies ethyl...
Chronic systemic hypertension causes cardiac pressure overload leading to increased myocardial O 2 consumption. Hypoxia-inducible factor 1 (HIF-1) is a master regulator of homeostasis. Mouse embryos lacking expression the -regulated HIF-1α subunit die at midgestation with severe malformations and vascular regression. Here we report that Hif1a f/f ;Tie2-Cre conditional knockout mice, which lack only in Tie2 + lineage cells, develop normally, but when subjected induced by transaortic...
To compare the efficacy and safety of neoadjuvant chemotherapy combined with concurrent chemoradiotherapy (NACT+CCRT) vs. (CCRT) in locally advanced cervical cancer (LACC) patients large tumor masses.
Malignant fibrous histiocytoma of the bone (MFH-B) is an extremely rare and aggressive malignancy. The clinicopathological characteristics prognosis patients with MFH-B have not been defined. We conducted a retrospective study using data all from Surveillance, Epidemiology End Results (SEER) database between 1975 2016. Initially, were described. difference in those osteosarcoma was compared propensity score matching analysis. Then, features affecting further determined Cox regression A total...
The editors are publishing this note to alert readers a concern about article (1).In Fig. 1B, the Western blot bands representing HIF-1a, HIF-2a, and actin were inadvertently also used in 1A of 2012 Oncogene publication by authors (2).The blots presented demonstrate knockdown efficiency subclones that for studies both papers.
<div>Abstract<p>The presence of hypoxia and fibrosis within the primary tumor are two major risk factors for metastasis human breast cancer. In this study, we demonstrate that hypoxia-inducible factor 1 activates transcription genes encoding collagen prolyl hydroxylases critical deposition by cancer cells. We show expression promotes cell alignment along fibers, resulting in enhanced invasion to lymph nodes lungs. Finally, establish prognostic significance hydroxylase mRNA...
<p>Supplementary Data PDF file 764K, Supplementary Figure S1, HIF-1 dependent P4HA1 and P4HA2 induction S2, knockdown inhibits breast cancer growth metastasis S3, Collagen hydroxylase decreases collagen deposition in vivo S4, of MDA-MB-435 cells S5, Picrosirius red staining mouse lungs S6, P4HA re-expression HIF-deficient rescues S7, DHB treatment MDA-MB-231 Cells Table Real-time qPCR primers. Supplemental Comparison human mRNA versus expression tumors. Correlation with receptor...
// Li Zeng 1 , Kaixue Hong Wei Jingjing Hu Lu Jiao Juan Zhang and Ying Xiong Department of Gastroenterology, The Second People’s Hospital Shenzhen, First Affiliated Shenzhen University, 518035, China Correspondence to: Xiong, email: yxiongmed@hotmail.com Keywords: colorectal cancer; epigenetic; gene methylation; prognosis Received: August 22, 2017     Accepted: November 13, Published: January 05, 2018 ABSTRACT Colorectal cancer (CRC) is the third most commonly...
Objective To understand the postoperative nutritional status and symptoms of gastric cancer patients, to analyze correlation between symptoms. Methods A total 110 patients in Peking University Cancer Hospital were enrolled from April December 2014 selected using convenience sampling. We assessed patient′s by human body measurement, lab test subjective global assessment (SGA). Memorial symptom scale (MSAS) was used evaluate these patients′ after operation. Results Based on...
Abstract Metastasis is the leading cause of death among patients who have breast cancer. Understanding role extracellular matrix in metastatic process may lead to development improved therapies treat cancer patients. Intratumoral hypoxia, found majority cancers, associated with an increased risk metastasis and mortality. Here we demonstrate that hypoxia-inducible factor 1 activates transcription genes encoding collagen prolyl hydroxylases are critical for deposition by cells. We identify...
<div>Abstract<p>The presence of hypoxia and fibrosis within the primary tumor are two major risk factors for metastasis human breast cancer. In this study, we demonstrate that hypoxia-inducible factor 1 activates transcription genes encoding collagen prolyl hydroxylases critical deposition by cancer cells. We show expression promotes cell alignment along fibers, resulting in enhanced invasion to lymph nodes lungs. Finally, establish prognostic significance hydroxylase mRNA...
Objective To observe the clinical therapeutic effect of Xuebijing injection on vascular endothelial cell (VEC) injury, microcirculation disorder and organ dysfunction in patients with sepsis. Methods Seventy-three sepsis were randomly divided into two groups: injection-treated group (40 cases) control (33 cases). Routine medicine therapy was applied both groups.Additionally, treated 100 ml saline by intravenous drip every 12 hours for consecutive 5 days.Vascular injury index,...
The E3 ligase SIAH1 is deregulated in human cancers and correlated with poor prognosis, but its contributions to chemoresistance epithelial ovarian cancer (EOC) are not evident. Herein we show that decreased EOC tumour tissues cell lines negatively RPS3 level. overexpression suppresses growth, colony formation, invasion, metastasis, cisplatin resistance vivo vitro. promoted ubiquitination degradation using the RING-finger domain, which was required for localization cytoplasm subsequent NF-κB...