A5035074937- Cancer Genomics and Diagnostics
- Cancer-related gene regulation
- RNA modifications and cancer
- Diabetes and associated disorders
- Lung Cancer Treatments and Mutations
- Epigenetics and DNA Methylation
- Reproductive Biology and Fertility
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Fungal Infections and Studies
- Pancreatic function and diabetes
- Immune cells in cancer
- Cardiac Ischemia and Reperfusion
- Ovarian function and disorders
- Cardiac Fibrosis and Remodeling
- Peptidase Inhibition and Analysis
- Asthma and respiratory diseases
- Immune Cell Function and Interaction
- Birth, Development, and Health
- Photosynthetic Processes and Mechanisms
- Cancer Diagnosis and Treatment
- Autophagy in Disease and Therapy
- Neuroinflammation and Neurodegeneration Mechanisms
- Traditional Chinese Medicine Analysis
- Cancer Immunotherapy and Biomarkers
- Cancer Cells and Metastasis
Guangdong Provincial People's Hospital
2022-2024
Guangdong Academy of Medical Sciences
2022-2024
Southern Medical University
2023-2024
Affiliated Hospital of Youjiang Medical University for Nationalities
2023-2024
Guangxi Medical University
2014-2024
First Affiliated Hospital of GuangXi Medical University
2014-2024
Xuzhou Medical College
2024
Guangzhou Medical University
2024
Xuzhou No.1 People's Hospital
2024
Changzhi Medical College
2024
How exosomal microRNAs (miRNAs) derived from macrophages contribute to the development of drug resistance in context hypoxic tumor microenvironment epithelial ovarian cancer (EOC) remains poorly understood.The miRNA levels were detected by qRT-PCR. Protein HIF-1α, CD163 and PTEN-PI3K/AKT pathway assessed Western blot (WB) Immunohistochemistry (IHC). Exosomes isolated, then confirmed Transmission electron microscopy (TEM), Nanoparticle Tracking Analysis (NTA) WB. Internalization...
Epidermal growth factor (EGF) is present in the maternal-fetal environment and has an important role placental development. Matrix metalloproteinase-9 (MMP-9) expression/activation a pre-requisite extravillous trophoblast invasion. Whereas EGF up-regulates MMP-9 activity variety of cell types, there no direct evidence for stimulation tissue inhibitor metalloproteinase-1 (TIMP-1) secretion by trophoblasts. In addition, signalling pathways involved this regulation are not clear. study, we have...
Drought decreases crop productivity more than any other type of environmental stress. Transcription factors (TFs) play crucial roles in regulating plant abiotic stress responses. The Arabidopsis thaliana gene DREB1A/CBF3, encoding a stress-inducible TF, was introduced into Salvia miltiorrhiza Ectopic expression AtDREB1A resulted increased drought tolerance, and transgenic lines had higher relative water content Chl content, exhibited an photosynthetic rate when subjected to plants generally...
While respiratory failure in cystic fibrosis (CF) frequently associates with chronic infection by Pseudomonas aeruginosa, no single factor predicts the extent of lung damage CF. To elucidate other causes, we studied autoantibody profile CF and rheumatoid arthritis (RA) patients, given similar association airway inflammation autoimmunity RA. Even though observed that bactericidal permeability-increasing protein (BPI), carbamylated proteins, citrullinated proteins all localized to neutrophil...
The β-cell has become recognized as a central player in the pathogenesis of type 1 diabetes with generation neoantigens potential triggers for breaking immune tolerance. We report that posttranslationally modified glucose-regulated protein 78 (GRP78) is novel autoantigen human diabetes. When islets were exposed to inflammatory stress induced by interleukin-1β, tumor necrosis factor-α, and interferon-γ, arginine residue R510 within GRP78 was converted into citrulline, evidenced liquid...
Abstract Liquid–liquid phase‐separated (LLPS) transcriptional factor assemblies at super‐enhancers (SEs) provide a conceptual framework for underlying control in mammal cells. However, the mechanistic understanding of LLPS aberrant transcription driven by dysregulation SEs human malignancies is still elusive. By integrating SE profiling and core regulatory circuitry (CRC) calling algorithm, CRC metastatic chemo‐resistant osteosarcoma delineated. components, HOXB8 FOSL1, produce dense dynamic...
RH6, RH8, and RH12 are previously unidentified D-body components drive the formation of D-bodies through LLPSs.
Primary hypothyroidism is a known complication of nephropathic cystinosis, lysosomal storage disorder characterized by renal failure as well deterioration other organs. The drug cysteamine depletes lysosomes cystine and helps preserve function enhance growth in cystinosis patients. To determine whether also prevents hypothyroidism, we retrospectively divided 101 patients into group A (n = 28; treated), B 26; partially C 47; poorly treated). Lifetable analysis indicated significantly higher...
Abstract Osteosarcoma (OS) is a common type of bone tumor for which there has been limited therapeutic progress over the past three decades. The prevalence transcriptional addiction in cancer cells emphasizes biological significance and clinical relevance super-enhancers. In this study, we found that Max-like protein X (MLX), member Myc-MLX network, driven by Upregulation MLX predicts poor prognosis osteosarcoma. Knockdown impairs growth metastasis osteosarcoma vivo vitro. Transcriptomic...
Modifications of both DNA and protein by methylation are key factors in normal T B cell immune responses as well the development autoimmune disease. For example, failure to maintain status CpG dinucleotides triggers autoreactivity. Methylated proteins known targets autoimmunity, including symmetrical dimethylarginine residues SmD1 SmD3 SLE. Herein, we demonstrate that altering metabolism S-adenosylmethionine (SAM), major methyl donor for transmethylation reactions, can suppress immunity. A...
Dehydration responsive element binding proteins (DREB) are transcription factors of the plant-specific AP2 family, many which contribute to abiotic stress responses in several plant species. We investigated possibility increasing drought tolerance traditional Chinese medicinal herb, Salvia miltiorrhiza, through modulating transcriptional regulation AtDREB1C transgenic plants under control a constitutive (35S) or drought-inducible (RD29A) promoter. S. miltiorrhiza showed increased survival...
Tanshinones are diterpenoid compounds that used to treat cardiovascular diseases. As current extraction methods for tanshinones inefficient, there is a pressing need improve the production of these bioactive meet increasing demand. Overexpression SmMDS (2-c-methyl-d-erythritol 2,4-cyclodiphosphate synthase, tanshinone biosynthesis gene) in transgenic Salvia miltiorrhiza hairy roots significantly increased yield compared control, and total content SmMDS-overexpressing lines after elicitor...
Reactive oxygen species (ROS) exposure triggers granulosa cells' (GCs) senescence, which is an important causal factor for premature ovarian failure (POF). However, underlying mechanism in this process remains unknown. In our study, we observed increased ROS levels POF tissues, patient follicular GCs and cyclophosphamide (CTX) pretreated GCs. Correspondingly, SIAH1, reduced TRF2 GC senescence were also found these cases. Silencing of SIAH1 rescued ROS-induced reduction cell Moreover,...
Ischemic stroke (IS) is a common neurological disease in the elderly, but relationship between neutrophil/albumin ratio (NAR) and leukocyte count/albumin (LAR) severity of function injury early deterioration (END) occurrence remain elusive acute IS. A total 299 patients with IS 56 healthy controls were enrolled. According to NIHSS score at admission, group was divided into three groups (mild, moderate severe IS), differences five indexes NAR, LAR, neutrophil count, count albumin among four...
Abstract This study was conducted to investigate the effect of melatonin during culture donor cells and cloned embryos on in vitro developmental competence quality porcine embryos. At concentrations 10 −6 m or −8 , significantly enhanced proliferation fetal fibroblasts ( PFF s), blastocyst rate increased −10 melatonin‐treated cell group. Cloned embryo development also improved medium that supplemented with −9 −12 melatonin. When both were treated melatonin, cleavage total number blastocysts...
Talaromyces marneffei (T. marneffei), a dimorphic fungus, causes local or disseminated infection in humans. We aimed to analyze the clinical characteristics, prognostic factors, and survival outcomes of patients with T. compare differences between human immunodeficiency virus (HIV)-positive HIV-negative subgroups.We retrospectively analyzed 241 at First Affiliated Hospital Guangxi Medical University January 2012 2022. The overall population was stratified into HIV-positive (n = 98) 143)...
Background Pulmonary enteric adenocarcinoma (PEAC) is a rare histological subtype of non-small-cell lung cancer (NSCLC) with predominant (>50%) differentiation component. The frequency high microsatellite instability (MSI-H) very low in cancer. EGFR tyrosine kinase inhibitors and immunotherapy are standard treatment for NSCLC patients, but their effectiveness pulmonary unknown. Case presentation This report describes 66-year-old man who was initially diagnosed metastatic mutation...
The combination of FOLFOX and bevacizumab (FOLFOX-Bev) is a promising treatment for advanced colorectal cancer (CRC). However, the response tumor microenvironment to FOLFOX-Bev still largely unexplored.We conducted single-cell transcriptomic analysis CRC samples derived from patient before after gain insights into cellular changes associated with treatment.We found that cells high proliferative, metastatic, pro-angiogenic properties respond better treatment. Moreover, enhances CD8+ T cell...