A5101476826- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Drug-Induced Hepatotoxicity and Protection
- RNA Research and Splicing
- Epigenetics and DNA Methylation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Ginger and Zingiberaceae research
- Neuroscience and Neuropharmacology Research
- Retinal Development and Disorders
- Photoreceptor and optogenetics research
- Ferroptosis and cancer prognosis
- Alcohol Consumption and Health Effects
- Systemic Lupus Erythematosus Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Genomics and Chromatin Dynamics
- interferon and immune responses
- Cancer-related Molecular Pathways
- Corporate Social Responsibility Reporting
- Immune cells in cancer
- Liver physiology and pathology
- Atherosclerosis and Cardiovascular Diseases
- Liver Disease Diagnosis and Treatment
- Histone Deacetylase Inhibitors Research
- RNA Interference and Gene Delivery
Sun Yat-sen University
2019-2024
Guangxi Medical University
2020-2023
Kaohsiung Medical University
2021-2023
Hezhou University
2023
Peking Union Medical College Hospital
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
Chang Bing Show Chwan Memorial Hospital
2021
Sun Yat-sen Memorial Hospital
2019
Jinan University
2017
Institute of Economic Development
2017
The N6-methyladenosine (m6A) modification influences various mRNA metabolic events and tumorigenesis, however, its functions in nonsense-mediated decay (NMD) whether NMD detects induced carcinogenesis pathways remain undefined. Here, we showed that the m6A methyltransferase METTL3 sustained oncogenic role by modulating of splicing factors alternative isoform switches glioblastoma (GBM). Methylated RNA immunoprecipitation-seq (MeRIP-seq) analyses peaks were enriched at pathway-related...
Abstract N6-methyladenosine (m 6 A) RNA methylation has recently been found involving in regulatory mechanism of the tumor progression. Our aim was to explore biological function and clinical significance m A methyltransferase METTL3 intrahepatic cholangiocarcinoma (ICC). In this study, we revealed that upregulated predicted poor prognosis patients with ICC. Multivariate regression analysis demonstrated expression an independent predictor for overall survival Moreover, knockdown inhibited...
Abstract Liquid–liquid phase‐separated (LLPS) transcriptional factor assemblies at super‐enhancers (SEs) provide a conceptual framework for underlying control in mammal cells. However, the mechanistic understanding of LLPS aberrant transcription driven by dysregulation SEs human malignancies is still elusive. By integrating SE profiling and core regulatory circuitry (CRC) calling algorithm, CRC metastatic chemo‐resistant osteosarcoma delineated. components, HOXB8 FOSL1, produce dense dynamic...
Abstract Background Despite the development of new treatment protocols for glioblastoma (GBM), temozolomide (TMZ) resistance remains a primary hindrance. Previous studies, including our study, have shown that aberrant N6‐methyladenosine (m 6 A) modification is implicated in GBM pathobiology. However, roles and precise mechanisms m A regulation TMZ remain unclear. Methods individual‐nucleotide‐resolution cross‐linking immunoprecipitation sequencing (miCLIP‐seq) was performed to identify...
Abstract Aberrant A‐to‐I RNA editing, mediated by ADAR1 has been found to be associated with increased tumourigenesis and the development of chemotherapy resistance in various types cancer. Intrahepatic cholangiocarcinoma (iCCA) is a highly aggressive malignancy poor prognosis, overcoming poses significant clinical challenge. This study aimed clarify roles tumour cisplatin iCCA. We discovered that expression elevated iCCA patients, particularly those resistant cisplatin, outcomes....
Immune checkpoint blockade (ICB) therapy can improve the survival of cancer patients with a high tumor mutation burden (TMB-H) or deficiency in DNA mismatch repair (dMMR) their tumors. However, most without TMB-H and dMMR do not benefit from ICB therapy. The inhibition ATM increase damage activate interferon response, thus modulating immune microenvironment (TIME) efficacy In this study, we showed that activated signaling induced interferon-stimulated genes (ISGs) cisplatin-resistant parent...
Abstract Excitatory amino acid transporters (EAATs) control visual signal transmission in the retina by rapidly removing glutamate released from photoreceptors and bipolar cells (BCs). Although it has been reported that EAAT2 EAAT5 are expressed at presynaptic terminals of some BCs mammals, distinct functions these two retinal synaptic transmission, especially a single synapse, remain elusive. In this study, we found was all BC types while coexisting with rod (RB) several cone mice either...
Retinal bipolar cells (BCs) compose the canonical vertical excitatory pathway that conveys photoreceptor output to inner retinal neurons. Although synaptic transmission from BC terminals is thought rely almost exclusively on Ca<sup>2+</sup> influx through voltage-gated (Ca<sub>V</sub>) channels mediating L-type currents, molecular identity of Ca<sub>V</sub> in BCs uncertain. Therefore, we combined and functional analyses determine expression profiles α<sub>1</sub>, β, α<sub>2</sub>δ subunits...
<h3>Abstract</h3> For decades, a role for the Ca<sup>2+</sup>-binding protein calmodulin (CaM) in Ca<sup>2+</sup>-dependent presynaptic modulation of synaptic transmission has been recognized. Here, we investigated influence CaM on evoked and spontaneous neurotransmission at rod bipolar (RB) cell→AII amacrine cell synapses mouse retina. Our work was motivated by observations that expression RB axon terminals is extremely high [Ca<sup>2+</sup>] normally rises sufficiently to saturate...
To improve the survival rate of cancer patients, biomarkers for both early diagnosis and patient stratification appropriate therapeutics play crucial roles in precision oncology. Investigation altered gene expression relevant molecular pathways cells are helpful discovering such biomarkers. In this study, we explore potential prognostic oral patients through systematically analyzing five transcriptomic data sets (TCGA, GSE23558, GSE30784, GSE37991, GSE138206). Gene Set Enrichment Analysis...
ATM and BRCA1 are DNA repair genes that play a central role in homologous recombination repair. Alterations of gene expression found cancers, some which correlated with treatment response patient outcome. However, the head neck cancer (HNC) is not well characterized. Here, we examined prognostic two HNC cohorts without betel quid (BQ) exposure. The results showed was downregulated BQ-associated HNC, as BQ ingredient arecoline could suppress both genes. Low either or poor overall survival...
There is currently a growing interest in the roles of epigenetic mechanisms diagnosis, prognosis, and therapies associated with precision oncology for breast cancer (BC). This study aimed to demonstrate clinical significance euchromatic histone lysine methyltransferase 2 (EHMT2), deacetylase 1 (HDAC1) HDAC2 BC, evaluate antitumor effectiveness combination selective inhibitors UNC0638 CI-994 (U+C), clarify underlying mechanisms.
In this study, we aimed to determine whether asiatic acid (AA) exerts any therapeutic effects on rifampicin (RFP)- and isoniazid (INH)-induced liver injury elucidate the underlying mechanisms. Briefly, in mice was induced via RFP INH administration. We investigated potential action mechanisms of AA using transcriptomics, metabolomics various examinations. found that significantly ameliorated pathological changes tissues decreased transaminase activity, inflammation oxidative stress damage....
Cigarette smoking is an established risk factor for autoimmune diseases. However, whether plays a clear role in thrombotic APS (TAPS) has not been determined. We aimed to investigate the effects of on clinical characteristics and prognosis TAPS.
摘要: 2015年中国300强企业慈善捐款达60.03亿元, 形成鲜明对照的是, 消费者对企业社会责任行为动机的质疑呈整体上升趋势。企业耗费巨资履行社会责任反遭遇感知伪善, 无疑与其初衷背道而驰, 而现有理论不能充分解释这一现象的原因。自Wagner等学者2009年在营销顶级期刊开启感知品牌伪善相关研究以来, 学者多从社会学借鉴感知个体伪善研究中言行不一的分析框架, 把企业社会责任单维化, 显然不能反映由多样性利益相关者所决定的企业社会责任类型的差异性和复杂性, 所以应从利益相关者视角揭示感知品牌伪善的形成机制。根据利益相关者特征划分企业社会责任类型——技术性和公共性, 进而引入其中间机制——合法性理论和感知道德资产理论, 最终验证企业社会责任类型的交互作用、企业社会责任类型与宣传的交互作用对感知品牌伪善的影响。考虑到企业社会责任的经济和社会双重影响, 这一成果将指引企业正确履行社会责任, 促进企业和社会良性互动。
<div>Abstract<p>The N<sup>6</sup>-methyladenosine (m<sup>6</sup>A) modification influences various mRNA metabolic events and tumorigenesis, however, its functions in nonsense-mediated decay (NMD) whether NMD detects induced carcinogenesis pathways remain undefined. Here, we showed that the m<sup>6</sup>A methyltransferase METTL3 sustained oncogenic role by modulating of splicing factors alternative isoform switches glioblastoma (GBM)....
<p>Supplementary Figures and Methods</p>
<p>Supplementary Figures and Methods</p>