A5100643246- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Genomics and Phylogenetic Studies
- MicroRNA in disease regulation
- Hepatocellular Carcinoma Treatment and Prognosis
- Phytochemical compounds biological activities
- RNA Research and Splicing
- Natural product bioactivities and synthesis
- Ultrasound and Hyperthermia Applications
- Galectins and Cancer Biology
- Photodynamic Therapy Research Studies
- Extracellular vesicles in disease
- Rough Sets and Fuzzy Logic
- Wave and Wind Energy Systems
- Endoplasmic Reticulum Stress and Disease
- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- RNA modifications and cancer
- Data Mining Algorithms and Applications
- Liver Disease Diagnosis and Treatment
- Glycosylation and Glycoproteins Research
- Advanced Algorithms and Applications
- Cytokine Signaling Pathways and Interactions
- Bladder and Urothelial Cancer Treatments
- Heat shock proteins research
Sun Yat-sen University
2016-2025
The First Affiliated Hospital, Sun Yat-sen University
2016-2025
Huadong Hospital
2018-2024
Fudan University
2016-2024
Tongji University
2008-2024
Chongqing University of Posts and Telecommunications
2022-2023
Western University
2023
University College London
2023
Zhongshan Hospital
2016-2022
McGill University
2022
For hyperspectral image (HSI) classification, two branch networks generally use the convolution neural (CNNs) to extract spatial features and long short-term memory (LSTM) learn spectral features. However, CNN with a local kernel neglects global properties of whole HSI. LSTM doesn't consider macroscopic detailed information spectra. In this paper, we propose dual-view feature fusion network (DSGSF) spatial-spectral for HSI including subnetwork subnetwork. subnetwork, representation model...
Chemodynamic therapy (CDT) that utilizes endogenous hydrogen peroxide (H2O2) to produce reactive oxygen species (ROS) kill cancer cells has shown a promising strategy for malignant tumor treatment. Nevertheless, limited H2O2 levels in the microenvironment often compromise therapeutic benefits of CDT, leading recurrence and metastasis. Herein, second near-infrared (NIR-II) photothermal Fenton nanocatalyst (PFN) was developed activatable magnetic resonance imaging (MRI)-guided synergetic (PTT)...
In this work, we developed a novel active targeting and pH-responsive system for delivering the drug doxorubicin (DOX) to tumor sites using folic acid (FA)-modified multiwalled carbon nanotubes (MWCNTs). Acid-treated MWCNTs with carboxyl groups were first covalently conjugated polyethyleneimine (PEI). Subsequent sequential modification FA (via polyethylene glycol spacer), fluorescein isothiocyanate (FI), acetic anhydride/triethylamine resulted in multifunctional FA-bound MWCNT...
Abstract Invasive pulmonary aspergillosis (IPA) in patients with diabetes mellitus has high incidence, especially Type 2 (T2DM). The aim of this study was to evaluate the diagnostic efficacy metagenomic next-generation sequencing (mNGS) for IPA T2DM. A total 66 T2DM were included, including 21 and 45 non-IPA patients, from January 2022 December 2022. demographic characteristics, comorbidities, laboratory test results, antibiotic treatment response, 30-day mortality rate analyzed. accuracy...
Interventional therapy is widely regarded as a highly promising treatment approach for nonsurgical liver cancer. However, the development of drug resistance and tolerance to hypoxic environments after embolization can lead increased angiogenesis, enhanced tumor cell stemness, greater invasiveness, resulting in metastasis recurrence. To address these challenges, novel involving use lecithin DSPE-PEG comodified Ca
Abstract Hepatocellular carcinoma (HCC) is the most common malignant tumor of liver. The early and effective diagnosis has always been desired. Herein, we present preparation characterization hyaluronic acid (HA)-modified, multifunctional nanoparticles (NPs) targeting CD44 receptor-expressing cancer cells for computed tomography (CT)/magnetic resonance (MR) dual-mode imaging. We first modified amine-terminated generation 5 poly(amidoamine) dendrimers (G5.NH 2 ) with an Mn chelator,...
Golgi phosphoprotein 3 (GOLPH3) has been frequently reported as an oncoprotein in a variety of tumors. However, its role the cancer-associated intercellular signaling communication not yet explored. This study aimed at exploring whether GOLPH3 regulates angiogenesis and sorafenib resistance via exosomal mechanisms hepatocellular carcinoma (HCC).In vivo assays were performed to elucidate function HCC. Exosomes HCC cells isolated by differential centrifugation, then measured quantified using...
Abstract Aberrant A‐to‐I RNA editing, mediated by ADAR1 has been found to be associated with increased tumourigenesis and the development of chemotherapy resistance in various types cancer. Intrahepatic cholangiocarcinoma (iCCA) is a highly aggressive malignancy poor prognosis, overcoming poses significant clinical challenge. This study aimed clarify roles tumour cisplatin iCCA. We discovered that expression elevated iCCA patients, particularly those resistant cisplatin, outcomes....
We report the construction and characterization of 99mTc-labeled arginine-glycine-aspartic acid (RGD)-polyethylenimine (PEI) conjugates with entrapped gold nanoparticles in cavities (RGD-99mTc-Au PENPs) for dual-mode single-photon emission computed tomography (SPECT)/computed (CT) imaging an orthotopic hepatic carcinoma model. In this study, PEI was successively decorated diethylenetriaminepentaacetic acid, poly(ethylene glycol) (PEG), PEGylated RGD segments, utilized as effective...
Near-infrared photothermal liposomal nanoantagonists with photo-controlled cargo release were developed for amplified cancer photodynamic therapy through inhibiting intracellular glutathione biosynthesis.
Abstract Due to the COVID‐19 pandemic, a series of sequelae, such as fatigue, tachypnea, and ageusia, appeared in long COVID patients, but pathological basis was still uncertain. The targeted radiopharmaceuticals were potential systemically dynamically trace changes. For key ACE2 protein virus‐host interaction, 68 Ga‐cyc‐DX600 developed on DX600 PET tracer fluctuation maintained ability differentiating ACE ACE2. In temporary infection model inhaled with radio‐traceable pseudovirus upper...
Macrophage migration inhibitory factor (MIF) is a pro‑inflammatory cytokine that serves important roles in cancer. MIF overexpression frequently observed numerous human cancer types, including pancreatic carcinoma. However, the prognostic value and function of ductal adenocarcinoma (PDAC) have not been fully elucidated. In present study, upregulation expression PDAC tissue compared with adjacent normal was observed. Furthermore, identified to be significantly associated poor survival rates...
Noncoding RNAs have been found to play important roles in DNA damage repair, whereas the participation of circRNA remains undisclosed. Here, we characterized ciRS-7, a containing over 70 putative miR-7-binding sites, as an enhancer miRISC condensation and repair. Both vivo vitro experiments confirmed TNRC6B AGO2, two core protein components human miRISC. Moreover, overexpressing ciRS-7 largely increased condensate number AGO2 cells, while silencing reduced it. Additionally, miR-7...
To investigate the immunogenic cross-reactivity among different novel duck reovirus isolates, animals immunized with monovalent inactivated were challenged homologous and heterologous viruses, serum samples collected after immunization for cross-neutralization test. The results showed that virus neutralizing titer against was significantly higher than virus(p < 0.000001), which indicated there an important difference in antigenicity between DE13 WL01 strains, affected specificity of...