A5088258230- Epigenetics and DNA Methylation
- Pancreatic and Hepatic Oncology Research
- RNA modifications and cancer
- Reproductive Health and Contraception
- Pancreatic function and diabetes
- Phagocytosis and Immune Regulation
- Cancer Mechanisms and Therapy
- Bariatric Surgery and Outcomes
- Endoplasmic Reticulum Stress and Disease
- Connective Tissue Growth Factor Research
- Sperm and Testicular Function
- Cancer, Lipids, and Metabolism
- Diet and metabolism studies
- Birth, Development, and Health
- Pregnancy and preeclampsia studies
- Cancer Research and Treatments
- Iron Metabolism and Disorders
- Diabetes Treatment and Management
- Nuclear Receptors and Signaling
- Macrophage Migration Inhibitory Factor
- Effects and risks of endocrine disrupting chemicals
- Protease and Inhibitor Mechanisms
- Cancer Cells and Metastasis
- Male Reproductive Health Studies
- Health, Environment, Cognitive Aging
Sun Yat-sen University
2018-2023
The First Affiliated Hospital, Sun Yat-sen University
2018-2023
Rutgers New Jersey Medical School
2017
Rutgers, The State University of New Jersey
2017
North Sichuan Medical University
2001-2011
Macrophage migration inhibitory factor (MIF) is a pro‑inflammatory cytokine that serves important roles in cancer. MIF overexpression frequently observed numerous human cancer types, including pancreatic carcinoma. However, the prognostic value and function of ductal adenocarcinoma (PDAC) have not been fully elucidated. In present study, upregulation expression PDAC tissue compared with adjacent normal was observed. Furthermore, identified to be significantly associated poor survival rates...
Abstract Cell-in-cell structures (CICs) refer to a type of unique structure with one or more cells within another one, whose biological outcomes are poorly understood. The present study aims investigate the effects CICs formation on tumor progression. Using genetically marked hepatocellular cancer cell lines, we explored possibility that might acquire genetic information and malignant phenotypes from parental undergoing formation. showed derivatives, isolated formed between two...
Background: Golgi phosphoprotein 3 (GOLPH3) overexpression was recently reported to be associated with a poor clinical outcome in patients colorectal cancer (CRC). However, the underlying molecular mechanism through which GOLPH3 promotes CRC metastasis remains poorly understood. Methods: In vitro genetic ablation of performed using siRNA transfection, and stably overexpressed colon cell line constructed lentivirus system. Cell invasion migration assays were conducted or without Matrigel....
Purpose. To investigate the effects of sleeve gastrectomy (SG) on glucose metabolism and changes in glucagon-like peptide 1 (GLP-1) Goto-Kakizaki (GK) rats. Methods. GK rats were randomly assigned to one three groups: SG, SG pair-fed plus sham surgery (PF-sham), ad libitum-fed no (control). Food intake, body weight, blood glucose, GLP-1 insulin levels, expression jejunum ileum compared. Results. The exhibited lower postoperative food fasting than did control (<mml:math...
Pancreatic ductal adenocarcinoma (PDAC) is associated with metaplastic changes in the pancreas but transcriptional program underlying these incompletely understood. The zinc finger transcription factor, PRDM3, lowly expressed normal pancreatic acini and its expression increases during tumorigenesis. Although PRDM3 promotes proliferation migration of PDAC cell lines, role tumor initiation from acinar cells vivo unclear. In this study, we showed that high levels human was pancreatitis,...
Overexpression of Golgi phosphoprotein 3 (GOLPH3) predicts poor prognosis and is a potential therapeutic target in pancreatic ductal adenocarcinoma (PDAC). However, its role underlying molecular mechanisms the progression PDAC remain unknown. In present study, using high-throughput bimolecular fluorescence complementation (BiFC) analysis, we identified that stress-inducible protein-1 (STIP1) interacts with GOLPH3 confirmed interaction co-localization co-immunoprecipitation. The levels STIP1...
Abstract Using stereological methods, especially the optical disector for unbiased estimation of nuclear number, our recent study demonstrated that long‐term (6 or 12 months) vasectomy in rhesus monkey had no significant effects on spermatogenesis (Peng et al. Reproduction 2002, 124, 847–856). This aimed to determine scenario rabbit using same morphometric methodology. Three groups normal male Japanese white rabbits (aged 4–5 were subjected unilateral vasectomy; 10 days, 6 months and later...
Golgi phosphoprotein 3 (GOLPH3), a proto-oncogene product, is significantly increased during the progression of several types cancer. However, its biological role and underlying mechanism in development renal cell carcinoma (RCC) remain poorly understood. In this study, GOLPH3 was found to be highly expressed RCC specimens compared corresponding non-tumor tissues. vitro, ectopic overexpression substantially promoted proliferative invasive capacity cells, while depletion inhibited...
It is frequently asked that how big a sample size, or much measurement, needed to achieve an accuratestereological estimate. The observed total error of stereological estimate arises from individual difference (i.e. i ter-animal / organ biological variation) and intra-individual variation (or the error). Statistical methods for analysis familiar most researchers are based on independent random sampling, however systematic which usually more efficient, almost always performed in practice. A...
Abstract Pancreatic ductal adenocarcinoma (PDAC) is associated with metaplastic changes in the pancreas but transcriptional program underlying these incompletely understood. The zinc finger transcription factor, PRDM3, lowly expressed normal pancreatic acini and its expression increases during tumorigenesis. Although PRDM3 promotes proliferation migration of PDAC cell lines, role tumor initiation from acinar cells vivo unclear. In this study, we showed that high levels human was...