A5101904309- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA Research and Splicing
- Circular RNAs in diseases
- Histone Deacetylase Inhibitors Research
- CRISPR and Genetic Engineering
- RNA Interference and Gene Delivery
- Genomics, phytochemicals, and oxidative stress
- Epigenetics and DNA Methylation
- Protein Degradation and Inhibitors
- Cancer, Lipids, and Metabolism
- Cancer-related gene regulation
- Advanced biosensing and bioanalysis techniques
- Genomics and Chromatin Dynamics
- Polysaccharides and Plant Cell Walls
- Acute Myeloid Leukemia Research
- Pharmacological Effects of Natural Compounds
- Cancer Research and Treatments
- Liver Disease Diagnosis and Treatment
- Retinoids in leukemia and cellular processes
- Medicinal plant effects and applications
- NF-κB Signaling Pathways
- Ferroptosis and cancer prognosis
- Thyroid Cancer Diagnosis and Treatment
Peking University Shenzhen Hospital
2025
Zunyi Medical University
2024
First Affiliated Hospital of Jiangxi Medical College
2024
Nanchang University
2024
University of Michigan
2024
Sun Yat-sen University
2009-2022
The First Affiliated Hospital, Sun Yat-sen University
2009-2022
Union Hospital
2021
Huazhong University of Science and Technology
2021
Zhoushan Hospital
2010-2013
Using DNA microarrays, we generated both mRNA and miRNA expression data from 6 non-small cell lung cancer (NSCLC) tissues their matching normal control adjacent to identify potential markers for diagnostics. We demonstrated that hsa-miR-96 is significantly consistently up-regulated in all NSCLCs. validated this result an independent set of 35 paired tumors tissues, as well sera are collected before surgical resection or chemotherapy, the results suggested may play important role NSCLC...
Although several miRNAs have been identified to be involved in glioblastoma tumorigenesis, little is known about the global expression profiles of and their functional targets astrocytomas at earlier stages malignancy. In this study mRNAs normal brain tissue samples grade I–III were analyzed parallelly using microarrays, grade-specific them obtained by unsupervised hierarchical clustering. It was also confirmed that miR-107, miR-124, miR-138, miR-149 downregulated significantly I–IV...
TFIIB ‐related factor 1 (Brf1) modulates the transcription of RNA Pol III genes (polymerase‐dependent genes). Upregulation enhances tRNA and 5S production increases translational capacity cells to promote cell transformation tumor development. However, significance Brf1 overexpression in human breast cancer ( HBC ) remains be investigated. Here, we investigate whether expression is increased samples , explore its molecular mechanism . Two hundred eighteen were collected determine by...
Macrophage migration inhibitory factor (MIF) is a pro‑inflammatory cytokine that serves important roles in cancer. MIF overexpression frequently observed numerous human cancer types, including pancreatic carcinoma. However, the prognostic value and function of ductal adenocarcinoma (PDAC) have not been fully elucidated. In present study, upregulation expression PDAC tissue compared with adjacent normal was observed. Furthermore, identified to be significantly associated poor survival rates...
Gastric cancer (GC) is one of the most common cancers worldwide. Tumor microenvironment plays an important role in tumor progression. This study aims to explore cancer-associated fibroblasts (CAFs) GC and underlying mechanism.
We aimed to investigate the possible signaling pathways underlying regulation of grape seed proanthocyanidins extracts (GSPE) on lipid metabolism. One hundred male C57BL/6 mice were divided into four groups: control group (normal diet), GSPE diet + GSPE), high‐fat (HFD), and plus (200 mg/kg/day) (HFD GSPE). Mice received diets for 180 days. Body weight serum levels measured. Autophagic flux characteristics, such as accumulation lipids, mitochondria, autophagosomes in liver, detected using...
LRRC4 is a tumor suppressor of glioma, and it epigenetically inactivated commonly in glioma. Our previous study has shown that induction expression inhibits the proliferation glioma cells. However, little known about mechanisms underlying action We employed two-dimensional fluorescence differential gel electrophoresis (2-D DIGE) MALDI -TOF/TOF-MS/MS to identify 11 differentially expressed proteins, including significantly down-regulated STMN1 LRRC4-expressing U251 The levels appeared be...
Cancer stem cells (CSCs) are a small population of undifferentiated cancer within tumors, which contribute to tumorigenicity and relapse. In the current study, CD133 (also termed prominin‑1), CSC marker, was investigated determine its involvement in predicting carcinogenesis prognosis patients with non‑small cell lung carcinoma (NSCLC). CD133‑positive were isolated analyze self‑renewal, differentiation tumorigenic abilities vitro vivo. Quantitative polymerase chain reaction used detect...
Abstract Triple negative breast cancer (TNBC) contains the highest proportion of stem-like cells (CSCs), which display intrinsic resistance to currently available therapies. This therapeutic is partially mediated by an antioxidant defense coordinated transcription factor NRF2 and its downstream targets including NQO1. Here, we identified enzymes NQO1 SOD1 as vulnerabilities ALDH+ epithelial-like CSCs CD24-/loCD44+/hi mesenchymal-like in TNBC. Effective targeting these CSC states was achieved...
Runx2 (Runt-related transcription factor 2) is a key which associated with osteoblast differentiation and expressed in ER+ (estrogen receptor positive) human breast cancer cell lines. also participates mammary gland development. Deregulation of RNA Pol III genes (polymerase III-dependent genes) tightly linked to tumor development, while Brf1 (TFIIB-related 1) specifically regulates these gene transcription. However, nothing known about the effect on expression Expression Runx2, from samples...
Antisense transcription of protein-coding genes has been increasingly recognized as an important regulatory mechanism gene expression. However, less is known about the extent and importance antisense noncoding genes. Here, we investigate breadth dynamics miRNAs, a class RNAs. Because transcript miRNA likely to form hairpin suitable substrate ADARs, which convert adenosine inosine in double-stranded RNAs, used A-to-I RNA editing ultrasensitive readout for miRNAs. Through examining unstranded...
The tumor microenvironment plays an important role in the progression and malignancy of lung adenocarcinoma affects immunotherapy response. There is increasing evidence that long non-coding RNAs (lncRNAs) as competing endogenous (ceRNAs) have significant functions development treatment response various kinds cancer. This study aimed to explore association between immune-related lncRNA-microRNA (miRNA)-messenger RNA (mRNA)-ceRNA networks, prognosis adenocarcinoma.RNA-sequencing (RNA-seq)...
Overexpression of PDE5 is observed in certain human cancers, but expression well-differentiated thyroid carcinoma (WDTC) unknown. We therefore examined and its relationship with the clinicopathological features WDTC. Real-time qPCR Western blotting were performed to analyze mRNA protein paired WDTC tumor adjacent nontumor tissues. Immunohistochemistry was used paraffin-embedded tissues obtained from 103 cases Statistical analyses examine correlation between features. The upregulated lesions...
<p>Supplementary data and table</p>
<div>Abstract<p>Triple-negative breast cancer (TNBC) contains the highest proportion of stem-like cells (CSC), which display intrinsic resistance to currently available therapies. This therapeutic is partially mediated by an antioxidant defense coordinated transcription factor NRF2 and its downstream targets that include NAD(P)H quinone oxidoreductase 1 (NQO1). In this study, we identified enzymes NQO1 superoxide dismutase (SOD1) as vulnerabilities ALDH<sup>+</sup>...
Long non-coding RNAs (lncRNAs) are a class of RNA molecules with transcripts longer than 200bp, which were initially thought to be noise from genomic transcription without biological function. However, since the discovery H19 in 1980 and Xist 1990, increasing evidence has shown that lncRNAs regulate gene expression at epigenetic, transcriptional post-transcriptional levels through specific regulatory actions, involved development cancer other diseases. Despite lower abundance protein-coding...