A5101759009- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Galectins and Cancer Biology
- Corneal surgery and disorders
- Immune Cell Function and Interaction
- Ophthalmology and Visual Impairment Studies
- RNA modifications and cancer
- RNA Interference and Gene Delivery
- Cancer Immunotherapy and Biomarkers
- Nutrition and Health in Aging
- Medical Imaging and Analysis
- Muscle Physiology and Disorders
- Glaucoma and retinal disorders
- Cancer, Hypoxia, and Metabolism
- DNA and Nucleic Acid Chemistry
- Intraocular Surgery and Lenses
- Wireless Networks and Protocols
- Fibroblast Growth Factor Research
- Advanced MIMO Systems Optimization
- Genetic Mapping and Diversity in Plants and Animals
- T-cell and B-cell Immunology
- Digital Imaging for Blood Diseases
- High Entropy Alloys Studies
- Power Line Inspection Robots
- Bioinformatics and Genomic Networks
East China University of Science and Technology
2019-2024
Southeast University
2023-2024
Fujian Agriculture and Forestry University
2024
Fudan University
2021-2023
Guangdong Academy of Medical Sciences
2023
Guangdong Provincial People's Hospital
2023
Huadong Hospital
2021-2023
South China University of Technology
2023
YangPu Geriatric Hospital
2021-2022
BioMimetic Systems (United States)
2022
Abstract Besides genome editing, CRISPR-Cas12a has recently been used for DNA detection applications with attomolar sensitivity but, to our knowledge, it not the of small molecules. Bacterial allosteric transcription factors (aTFs) have evolved sense and respond sensitively a variety molecules benefit bacterial survival. By combining single-stranded cleavage ability competitive binding activities aTFs double-stranded DNA, here we develop simple, supersensitive, fast high-throughput platform...
Background: Recent evidence indicates that host-gut microbiota crosstalk has nonnegligible effects on host skeletal muscle, yet gut microbiota-regulating mechanisms remain obscure.Methods: C57BL/6 mice were treated with a cocktail of antibiotics (Abx) to depress for 4 weeks. The profiles and microbial bile acids measured by 16S rRNA sequencing ultra-performance liquid chromatography (UPLC), respectively. We performed qPCR, western blot ELISA assays in different tissue samples evaluate...
Abstract Background Despite the development of new treatment protocols for glioblastoma (GBM), temozolomide (TMZ) resistance remains a primary hindrance. Previous studies, including our study, have shown that aberrant N6‐methyladenosine (m 6 A) modification is implicated in GBM pathobiology. However, roles and precise mechanisms m A regulation TMZ remain unclear. Methods individual‐nucleotide‐resolution cross‐linking immunoprecipitation sequencing (miCLIP‐seq) was performed to identify...
Abstract Liquid–liquid phase‐separated (LLPS) transcriptional factor assemblies at super‐enhancers (SEs) provide a conceptual framework for underlying control in mammal cells. However, the mechanistic understanding of LLPS aberrant transcription driven by dysregulation SEs human malignancies is still elusive. By integrating SE profiling and core regulatory circuitry (CRC) calling algorithm, CRC metastatic chemo‐resistant osteosarcoma delineated. components, HOXB8 FOSL1, produce dense dynamic...
Abstract Osteosarcoma (OS) is a common type of bone tumor for which there has been limited therapeutic progress over the past three decades. The prevalence transcriptional addiction in cancer cells emphasizes biological significance and clinical relevance super-enhancers. In this study, we found that Max-like protein X (MLX), member Myc-MLX network, driven by Upregulation MLX predicts poor prognosis osteosarcoma. Knockdown impairs growth metastasis osteosarcoma vivo vitro. Transcriptomic...
This article presented a case of human leukocyte antigen (HLA)-A2-positive patient with advanced cancer/testis New York esophageal squamous cell carcinoma-1 (NY-ESO-1) expressing lung adenocarcinoma (LADC) who received adoptive therapy T receptor engineered-T cells (TCR-T cells) targeting the cancer-testis NY-ESO-1. The appropriate clinical and laboratory assessments were conducted to investigate safety efficacy this for cancer patient. had response was well-tolerated in trial. In addition,...
A nano-Apatinib delivery system overcomes drug resistance by targeting osteosarcoma stem-like cells.
The laboratory rat is a major model organism for systems biology. To complement the cornucopia of physiological and pharmacological data generated in rat, large genomic toolset has been developed, culminating release draft genome sequence. sequence used variety assembly packages, as well from Radiation Hybrid (RH) map part their validation. As Rat Genome Project, we have building high-density RH to facilitate integration multiple maps now help validate assembly. By incorporating vectors our...
Histone H3K27 demethylase, JMJD3 plays a critical role in gene expression and T-cell differentiation. However, the mechanisms of T cell trafficking remain poorly understood. Here we show that deficiency CD4+ cells resulted an accumulation thymus, reduction number secondary lymphoid organs. We identified PDLIM4 as significantly down-regulated target JMJD3-deficient by profiling ChIP-seq analyses. further showed functioned adaptor protein to interact with S1P1 filamentous actin (F-actin), thus...
Abstract Background The incidence and mortality rates of hepatocellular carcinoma are among the highest all cancers over world. However survival relatively low due to lack effective treatments. Efforts elucidate mechanisms HCC find novel prognostic markers therapeutic targets ongoing. Here we tried identify genes through co-expression network analysis. Methods We conducted weighted gene analysis with a microarray dataset GSE14520 from Gene Expression Omnibus database identified hub module...
Integration of the large variety genome maps from several organisms provides mechanism by which physiological knowledge obtained in model systems such as rat can be projected onto human to further research on disease. The release sequence new information for studies using and is a key reference against existing results aligned. Previously, we described comparative rat, mouse, based EST comparisons combined with radiation hybrid maps. Here, use data introduce Integrated Genomics Environment,...
The purpose of this study was to investigate the illness uncertainty and its influencing factors in patients after heart stent implantation, explore relationship between disease, self-management behavior coronary disease quality life stenting.A cross-sectional 168 with cardiac implantation on a tertiary hospital Shanghai. General Information Questionnaire Mishel's Uncertainty Illness Scale (MUIS) used measure stenting, Coronary Self-Management (CSMS) 36-item Short Form Health Survey (SF-36)...
A common observation in metabolic disorders and aging is the elevation of free fatty acids (FFAs), which can form ectopic fat deposition result lipotoxicity. Ectopic skeletal muscle has been recognized as an important component aging, frailty, sarcopenia. Previous studies have suggested that lipotoxicity caused by FFAs mainly stemmed from saturated decreased unsaturated/saturated acid ratio serum are also observed among disorder patients. However, different effects unsaturated on not fully...
AIM: To analyze the effect of steep meridian small incision phacoemulsification cataract surgery on anterior, posterior and total corneal wavefront aberration. METHODS: Steep was performed in age-related patients which were divided into three groups according to site: 12 o’clock, 9 o’clock between (BENT) groups. The preoperative 3-month postoperative root mean square (RMS) values aberration including coma, spherical aberration, higher-order aberrations (HOAs), measured by Pentacam...
Frailty is one of the most problematic expressions population aging, but its underlying mechanism has not been fully elucidated. Circulating galectin-3 (Gal-3) involved in pathogenesis many age-related diseases. This study aims to explore influence circulating Gal-3 on regulation frailty and aging identify potential further.In this cross-sectional analysis, Fried phenotype (FP) was assessed among 149 community elderly residents Shanghai. Peripheral blood mononuclear cells (PBMCs) were...