A5100627251- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- RNA modifications and cancer
- MicroRNA in disease regulation
- RNA Research and Splicing
- Cancer, Hypoxia, and Metabolism
- Cancer-related gene regulation
- Ferroptosis and cancer prognosis
- AI in cancer detection
- Aldose Reductase and Taurine
- Cancer-related Molecular Pathways
- Click Chemistry and Applications
- Mitochondrial Function and Pathology
- ATP Synthase and ATPases Research
- Image and Signal Denoising Methods
- Generative Adversarial Networks and Image Synthesis
- Fibroblast Growth Factor Research
- Cancer Mechanisms and Therapy
- Heme Oxygenase-1 and Carbon Monoxide
- Nanoparticle-Based Drug Delivery
- Acute Myeloid Leukemia Research
Inner Mongolia University of Science and Technology
2025
Baotou Medical College
2025
Jiangsu University
2014-2024
Shaoxing Second Hospital
2021
Linyi People's Hospital
2020
First Affiliated Hospital of Wenzhou Medical University
2019
Wenzhou Medical University
2019
Zero to Three
2014
Affiliated Hospital of Jiangsu University
2014
Northwest A&F University
2013-2014
Multidrug resistance (MDR) remains a major obstacle to effective chemotherapy treatment in ovarian cancer. In our study, paclitaxel‐resistant cancer patients and cell lines had decreased miR‐145 levels expressed high of Sp1 Cdk6. Introducing into SKOV3/PTX A2780/PTX cells led reduction Cdk6 along with downregulation P‐gp pRb. These changes resulted increased accumulation antineoplastic drugs G1 cycle arrest, which rendered the more sensitive paclitaxel vitro vivo . effects could be reversed...
MicroRNAs constitute a class of ~22-nucleotide non-coding RNAs. They modulate gene expression by associating with the 3' untranslated regions (3' UTRs) messenger RNAs (mRNAs). Although multiple miRNAs are known to be regulated during myoblast differentiation, their individual roles in muscle development still not fully understood. In this study, we showed that miR-199a-3p was highly expressed skeletal and induced C2C12 myoblasts differentiation. We also identified confirmed several genes...
MicroRNAs (miRNAs), a class of small non-coding RNAs, have emerged as novel and potent regulators adipogenesis. However, few miRNAs been fully investigated in porcine adipogenesis, given the fact that pig is not only an apropos model human obesity research, but also staple meat source diet. In this study, we showed miRNA-199a-5p highly expressed subcutaneous fat deposits compared to several other tissue types organs measured alongside. Overexpression miR-199a-5p preadipocytes significantly...
Abstract Tumor-associated lncRNAs regulated by epigenetic modification switches mediate immune escape and chemoresistance in ovarian cancer (OC). However, the underlying mechanisms concrete targets have not been systematically elucidated. Here, we discovered that methylation modifications played a significant role regulating cell infiltration sensitizing OC to chemotherapy modulating immune-related (irlncRNAs), which represent tumor status. Through deep analysis of TCGA database, prognostic...
Breast cancer (BC) is the most frequent malignancy occurring in women worldwide. Emerging evidence indicates that small nucleolar RNAs (snoRNAs) play a role tumor development. In current study, we evaluated expression profiles and functions of snoRNAs associated with BC.We analyzed levels between breast normal tissues TCGA database found SNORA7B upregulated BC. We confirmed this result clinical BC cell lines via qRT-PCR. Then, investigated significance public datasets biological function...
Long non-coding RNA testis-specific transcript, Y-linked 15 (TTTY15) is oncogenic in prostate cancer, however its expression and function colorectal cancer remain largely unknown.Paired samples/normal tissues were collected, the levels of TTTY15, miR-29a-3p disheveled segment polarity protein 3 (DVL3) examined by quantitative real-time polymerase chain reaction (qRT-PCR); TTTY15 shRNA overexpression plasmids transfected into HT29 HCT-116 cell lines using lipofectamine reagent, respectively;...
Papillary thyroid carcinoma (PTC) is the most common type of carcinoma, which associated with a high incidence lymph-node metastasis. Multiple biomarkers have been identified for precise diagnosis PTC at an early stage. However, their role in remains poorly elucidated. Previously, we reported that lipase H (LIPH), membrane-bound protein, was highly expressed PTC. This study aimed to fully elucidate causal LIPH development and investigated its relationship metastasis PTC.Quantitative reverse...
Purpose: Aldo-keto reductase family 1, member C2 (AKR1C2) gene encodes for a of the AKR superfamily and participates in metabolism various drugs.Moreover, tumor normal tissues exhibit an evident difference expression level this gene.Methods: We downloaded analyzed AKR1C2 data consisting clinicopathological features 490 papillary thyroid carcinoma (PTC) 59 from The Cancer Genome Atlas (TCGA) cohort.Diverse statistical methods, such Chi-square test, univariate multivariate Cox regression...
<p>Extended Material and Methods</p>
Abstract Background: Long non-coding RNA TTTY15 is oncogenic in prostate cancer, however its expression and function colorectal cancer remain largely unknown.Methods: Paired samples/adjacent tissues were collected, the levels of TTTY15, miR-29a-3p disheveled segment polarity protein 3 (DVL3) examined by quantitative real-time polymerase chain reaction (qRT-PCR). shRNAs transfected into HT-29 HCT-116 cell lines using lipofectamine reagent; proliferation colony formation detected CCK-8 assay...