A5102730199- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- RNA modifications and cancer
- Circular RNAs in diseases
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer, Lipids, and Metabolism
- Reproductive System and Pregnancy
- Extracellular vesicles in disease
- Ferroptosis and cancer prognosis
- Wastewater Treatment and Nitrogen Removal
- Esophageal Cancer Research and Treatment
- RNA Research and Splicing
- Anaerobic Digestion and Biogas Production
- Metabolism, Diabetes, and Cancer
- Reproductive Biology and Fertility
- Cardiac, Anesthesia and Surgical Outcomes
- Esophageal and GI Pathology
- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
- Cancer-related gene regulation
- Immune cells in cancer
- Cancer Mechanisms and Therapy
- Autophagy in Disease and Therapy
- Atherosclerosis and Cardiovascular Diseases
Shanghai Medical College of Fudan University
2021-2025
Fudan University Shanghai Cancer Center
2016-2025
Jiangsu University
2023-2025
Affiliated Hospital of Jiangsu University
2023-2025
Nanchang University
2020-2025
First Affiliated Hospital of Nanchang University
2020-2025
Shanghai Institute of Hypertension
2022-2025
Southern Medical University
2023-2024
Nanfang Hospital
2023-2024
Guangxi Medical University
2024
<b>Background and study aims:</b> Endoscopic submucosal dissection (ESD) is accepted as an established treatment modality for superficial esophageal carcinoma (SEC). The aim of this was to identify risk factors postoperative stricture after ESD SEC. <b>Patients methods:</b> This a retrospective at single institution. A total 362 patients with SEC treated by Zhongshan Hospital, Shanghai, were enrolled between January 2007 February 2012. Demographic clinical parameters, including patient-,...
Background & AimsmicroRNAs (miRNAs) have been reported to regulate angiogenesis by down-regulating the expression of pro-angiogenic or anti-angiogenic factors. The aims this study were investigate whether miR-26a inhibited vascular endothelial growth factor A (VEGFA) and its clinical relevance in hepatocellular carcinoma (HCC). MethodsThe was modified HepG2 HCCLM3 cell lines respectively, a panel angiogenic factors measured real-time PCR cells. luciferase reporter assay used validate target...
Abstract Background Premature ovarian insufficiency (POI) is an important cause of female infertility and seriously impacts the physical psychological health patients. Human umbilical cord mesenchymal stem cell-derived exosomes (HucMSCs-Exs, H-Exs) have exhibited protective effects on function with unclear mechanisms. Methods A comprehensive analysis Gene Expression Omnibus (GEO) database were used to identify POI-associated circRNAs miRNAs. The relationship between HucMSC-derived exosomal...
Abstract Commensal bacteria are critical for physiological functions in the gut, and dysbiosis gut may cause diseases. In this article, we report that mice deficient cathelin-related antimicrobial peptide (CRAMP) were defective development of colon mucosa highly sensitive to dextran sulfate sodium (DSS)-elicited colitis, as well azoxymethane-mediated carcinogenesis. Pretreatment CRAMP−/− with antibiotics markedly reduced severity DSS-induced suggesting CRAMP a limiting factor on colon. This...
Monoacylglycerol lipase (MAGL), a critical lipolytic enzyme, has emerged as key regulator of tumor progression, yet its biological function and clinical significance in hepatocellular carcinoma (HCC) is still unknown. In this study, we used tissue microarray containing samples from 170 HCC patients to evaluate the expression MAGL correlation with other clinicopathologic characteristics. addition, investigated regulating effects on various lines. Finally, identified NF-κB signaling pathway...
Abstract Premature ovarian failure (POF) is an important cause of female infertility and seriously impacts the physical psychological health patients. Mesenchymal stromal cells-derived exosomes (MSCs-Exos) have essential role in treatment reproductive disorders, particularly POF. However, biological function therapeutic mechanism MSCs exosomal circRNAs POF remain to be determined. Here, with bioinformatics analysis functional assays, circLRRC8A was found downregulated senescent granulosa...
Abstract Phenotype switch of vascular smooth muscle cells (VSMCs) plays an important role in the development atherosclerosis (AS). Endothelial can regulate VSMC phenotypic by secreting exosomes, crucial mediators intracellular communication. This study aimed to determine whether exosomal LINC01005 from oxidized low‐density lipoprotein (ox‐LDL)‐treated human umbilical vein endothelial (HUVECs) a regulating and validate underlying molecular mechanism. Exosomes were extracted ox‐LDL‐treated...
Accumulating evidences have suggested that bone morphogenetic protein (BMP)-Smad a functional role in regulating autophagy the development of human colorectal cancer (CRC). However, regulatory mechanisms controlling this process remain unclear. Here, we showed Smad1, key effector BMP2-Smad signaling, induces by upregulating autophagy-related gene 5 (ATG5) expression, and Smad1 binds to proximal promoter induce its expression. Moreover, BMP2 CRC. Overexpression promotes tumorigenesis...
Abstract AGO1 is a major component of RNA-induced silencing complexes and plays crucial role in solid tumors. The aim our study was to investigate functions hepatocellular carcinoma (HCC). Using small interfering RNA, were investigated HCCLM3 cell lines. Cell proliferation, immigration, invasion significantly decreased after depletion using MTT, wound-healing, transwell assay. associated proteins the epithelial–mesenchymal transition (EMT) activation its signal pathways measured western...
Recently, interest in investigating the effects of long noncoding RNAs (lncRNAs) on endometrial receptivity (ER) has increased within field assisted reproductive technology. Therefore, objective this study is to identify and analyze role lncRNA LUCAT1 elucidate its specific mechanism regulating ER. Hub genes associated with ER are identified via Weighted gene co-expression network analysis (WGCNA) two datasets downloaded from GEO database. These hub WGCNA were subsequently validated. The...
Accumulating evidences indicate that periodontitis is closely associated with endothelial dysfunction. Trimethylamine-N-oxide (TMAO), a harmful microbiota generated metabolite, has been implicated as nontraditional risk factor for impaired function. However, whether increased circulating levels of TMAO in patients induces dysfunction remains unknown. Patients and periodontally healthy controls were enrolled. Periodontal inflamed surface area (PISA) was calculated to assess the inflammatory...
Abstract Mitochondrial metabolism has been shown to play a key role in immune cell survival and function, but mitochondrial creatine kinase 2 (CKMT2) relatively little studied about tumor immunity. We aimed explore the prognostic value of CKMT2 33 cancer types investigate its potential function. used range bioinformatics approaches carcinogenic multiple cancers. was lowly expressed 14 tissues highly 4 tissues. Immunohistochemical assays showed overexpression colon rectal cancer. positively...
Background: Hepatocellular carcinoma (HCC) is one of the common primary cancers liver worldwide and leading cause mortality.Gasdermins (GSDMs) family genes play an important role in regulation normal physiological processes have been implicated multiple diseases.However, little known about relationship between different GSDMs proteins HCC.The aim this study was to explore potential expression, prognosis, genetic variation immune infiltration HCC.Methods: We used bioinformatics public...
Abstract Premature ovarian failure (POF) affects many adult women less than 40 years of age and leads to infertility. Mesenchymal stem cells-derived small extracellular vesicles (MSCs-sEVs) are attractive candidates for function restoration folliculogenesis POF due their safety efficacy, however, the key mediator in MSCs-sEVs that modulates this response underlying mechanisms remains elusive. Herein, we reported YB-1 protein was markedly downregulated vitro vivo models induced with H 2 O CTX...