A5100323890- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Corneal Surgery and Treatments
- RNA Research and Splicing
- MRI in cancer diagnosis
- Atrial Fibrillation Management and Outcomes
- Hormonal Regulation and Hypertension
- S100 Proteins and Annexins
- Breast Lesions and Carcinomas
- Corneal surgery and disorders
- interferon and immune responses
- Aortic aneurysm repair treatments
- Ultrasound and Hyperthermia Applications
- Renin-Angiotensin System Studies
- Apelin-related biomedical research
- Advanced Neuroimaging Techniques and Applications
- Protease and Inhibitor Mechanisms
- Ultrasound Imaging and Elastography
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Growth Hormone and Insulin-like Growth Factors
- Advanced Breast Cancer Therapies
- Pregnancy-related medical research
- Infectious Aortic and Vascular Conditions
Ningxia Medical University
2025
Qilu Hospital of Shandong University
2013-2024
Inner Mongolia Medical University
2024
Tianjin Medical University
2024
First Affiliated Hospital of Soochow University
2024
Soochow University
2024
Chinese PLA General Hospital
2023
Shandong University
2014-2022
Yixing People's Hospital
2020
Jiangsu University
2020
Objectives Circular RNAs (circRNAs) have been proven to function as competing endogenous interact with microRNAs (miRNAs) and influence the expression of miRNA target mRNAs. In this study, we investigated whether circRNAs could act regulate pathological process intervertebral disc degeneration (IVDD). Methods The role mechanism a circRNA, circVMA21, in IVDD were explored nucleus pulposus (NP) cells degenerative NP tissues from patients rat models. interaction between circVMA21 miR-200c well...
Abstract Breast cancer ranks no. 1 in women worldwide, while 60–70% are estrogen receptor alpha positive. The selective modulators, such as tamoxifen, become the effective drugs for controlling ER breast progression. However, tamoxifen resistance will develop during long-time treatment and Thus, further understanding of signaling becomes necessary improvement therapy. Here, we identify TRIM56 a novel regulatory factor signaling. expression is positively correlated with PR samples related to...
Abstract Hippo signaling restricts tissue growth by inhibiting the transcriptional effector YAP. Here we uncover a role of and tumor suppressor function YAP in estrogen receptor positive (ER + ) breast cancer. We find that inhibition Hippo/MST1/2 or activation blocks ERα program ER cancer growth. Mechanistically, pathway transcription factor TEAD physically interacts with to increase its promoter/enhancer occupancy whereas inhibits ERα/TEAD interaction, decreases on target...
Limbal stem cells (LSCs) derived from human embryonic (hESCs) hold great potential for cell-based therapies ocular surface diseases. The mainly depend on an appropriate differentiation proposal with a high efficiency and suitable scaffold. In this study, we aimed to establish feasible efficient strategy inducing hESCs into LSC-like by the LSC conditioned medium. induced possessed similar morphologic characteristics expression of normal LSCs showed strong clonogenic proliferative capacity in...
Triple-negative breast cancer (TNBC) has the highest mortality rate of all subtypes and currently lacks effective targeted therapies. LARP6 is an RNA-binding protein associated with promotion, but its mechanism action in TNBC remains unclear. We conducted RNA sequencing (RNA-seq) improved immunoprecipitation (iRIP-seq) to identify differentially expressed genes (DEGs) alternative splice sites bound regulated by MDA-MB-231 cells. Finally, both RT-qPCR RIP-qPCR were employed for verification....
This study aims to investigate the efficacy of glueless simple oral mucosal transplantation prevent development limbal stem cell deficiency in rabbit model. Rabbit (LSCD) models were constructed with alcohol and mechanical scraping. The mucosa tissue harvested cut into small pieces. Microincisions made on corneal limbus precut pieces inserted in. Animals divided three groups: epithelium (GSOMT), (GSLET) LSCD group. Corneal defects, opacity neovascularization observed after surgery by...
Abstract Ischemic stroke is a severe neurological disease, with high morbidity and mortality worldwide. To date, the treatment of ischemic limited, its consequent ischemia‐reperfusion injury an important reason for this result. Excessive reactive oxygen species (ROS) inflammatory storm followed by alter microenvironment cerebral penumbra, leading to devastating damage brain. Herein, we design black phosphorus nanosheets (BPNSs) loaded magnesium ions (Mg 2+ ) polydopamine (PBP@Mg) tackle...
The aim of this study was to investigate the feasibility inducing rat neural crest cells (NCC) differentiate functional corneal endothelial cell (CEC)-like in vitro. Rat NCC were induced with adult CEC-derived conditioned medium. Immunofluorescence, flow cytometry and real time RT-PCR assay used detect expression endothelium differentiation marker N-cadherin transcription factors FoxC1 Pitx2. CFDA SE-labeled CEC-like transplanted a deficiency model, an eye-down position maintained for 24...
// Rui Wang 1,* , Dong-Qin Chen Jia-Yuan Huang 1 Kai Zhang Bing Feng Ban-Zhou Pan Jing Wei De 2 Long-Bang Department of Medical Oncology, Jinling Hospital, School Medicine, Nanjing University, Nanjing, Jiangsu 210002, China Biochemistry and Molecular Biology, * Co-first authors Correspondence: Chen, email: Keywords : lung adenocarcinoma, chemoresistance, radioresistance, miR-451, c-Myc, rad-51, survivin Received May 26, 2014 Accepted July 05, Published 07, Abstract Chemoresistant tumors...
Inflammation is the body's normal self-protection mechanism to eliminate pathogens and resist pathogen invasion. The excessive inflammatory response may lead lesions. mechanisms accounting for inflammation remain hazy. miRNAs have been proposed crucial effects on inflammation. In present study, we reported that lipopolysaccharide (LPS)-stimulation increased expression levels of cytokines cell-cycle progression was suppressed in RAW264.7 cells. Meanwhile, miR-322 significantly down-regulated...
The incidence of pancreatic cancer is increasing annually in Asia as a whole. Pancreatic ranks sixth terms all malignant tumors. Circular RNA (circRNA) type non-coding which forms covalently closed continuous loop. CircRNA extensively expressed the cytoplasm, and markedly conservative stable. MicroRNA (miR)-378a-3p human (hsa)_circ_0006215 were detected using reverse transcription-quantitative polymerase chain reaction (RT-qPCR) tissue cells. Western blot analysis SERPINA4 hsa_circ_0006215...
Abstract Background Chordoma, a rare bone tumour with aggressive local invasion and high recurrence rate limited understanding of its molecular mechanisms. Circular RNAs (circRNAs) have been extensively implicated in tumorigenesis, yet their involvement chordoma remains largely unexplored. N6‐methyladenosine (m6A) modification holds crucial function regulating protein translation, RNA degradation transcription. Methods Initially, screening validation circTEAD1 were conducted by...
Nanoporous gold (NPG) based biosensors have been constructed by covalently immobilizing glucose oxidase (GOx) onto self-assembled monolayers (SAMs). With p-benzoquinone (BQ) as a mediator, diffusion behavior and amperometric biosensor performance are evaluated electrochemical characterization. The enzyme modified electrodes demonstrated to show thickness-sensitive behavior. Compared with planar polycrystalline gold, the unique porous structure of NPG has also characterized via an surface...
OBJECTIVE: To investigate the usefulness of diffusion-weighted imaging (DWI)-guided, single-voxel proton magnetic resonance spectroscopy (SVS) for preoperative evaluation cerebral glioma grade. METHODS: For SVS, placement volume-of-interest was guided by minimal apparent diffusion coefficient value obtained from DWI. Spectral data N-acetylaspartate (NAA), choline (Cho), and phosphocreatine (Cr) were analysed in 33 patients with primary gliomas. RESULTS: Cho/Cr Cho/NAA ratios significantly...
A number of studies have shown that apoptosis resistance can be observed in multiple human tumors; however the detailed mechanism remains unclear. In present study, we demonstrated abnormal overexpression C terminus Hsc70-interacting protein (CHIP) induced by regulating AKT/FoxO/Bim signaling pathway breast cancer cell MCF7 and non-tumorigenic MCF10A. We found CHIP MCF10A cells activated AKT inhibited Forkhead box O (FoxO) transcription factors FoxO1, FoxO3, FoxO4, thereby inhibiting target...
Abstract CD4 + CD25 regulatory T cells (Tregs) have been shown to protect against the development of abdominal aortic aneurysm (AAA). Cyclooxygenase‐2 (COX‐2), a pro‐inflammatory protein, can convert arachidonic acid into prostaglandins (PGs). The present study was aimed investigate effect Tregs on COX‐2 expression in angiotension II (Ang II)‐induced AAA ApoE −/− mice. were injected via tail vein every 2 weeks. Ang continuously infused by micropump for 28 days induce AAA. In vivo, compared...
Abstract MiR‐4732‐5p was previously found to be dysregulated in nipple discharge of breast cancer. However, the expression and function miR‐4732‐5p cancer remain largely unknown. Here, detected using quantitative real‐time PCR tissues cell lines. Cell proliferation, apoptosis, migration invasion assays were performed examine effects In addition, mRNA sequencing, bioinformatics analysis, Western blot luciferase identify target miR‐4732‐5p. Overall, significantly down‐regulated tissues,...