A5101607495- Atherosclerosis and Cardiovascular Diseases
- Renin-Angiotensin System Studies
- Aortic aneurysm repair treatments
- Immune cells in cancer
- Hormonal Regulation and Hypertension
- T-cell and B-cell Immunology
- Apelin-related biomedical research
- Cell Adhesion Molecules Research
- Cancer-related molecular mechanisms research
- Cytokine Signaling Pathways and Interactions
- Pulmonary Hypertension Research and Treatments
- Inflammatory mediators and NSAID effects
- Lipoproteins and Cardiovascular Health
- Galectins and Cancer Biology
- Cardiovascular and Diving-Related Complications
- Circular RNAs in diseases
- Viral Infections and Immunology Research
- Cardiovascular Function and Risk Factors
- Diabetes and associated disorders
- Immune Cell Function and Interaction
- Kawasaki Disease and Coronary Complications
- Cancer Immunotherapy and Biomarkers
- Takotsubo Cardiomyopathy and Associated Phenomena
- Coronary Artery Anomalies
- Heat shock proteins research
Xuzhou Medical College
2025
Qilu Hospital of Shandong University
2013-2025
Shandong First Medical University
2025
Shanghai Ninth People's Hospital
2017-2025
Shanghai Jiao Tong University
2018-2025
Shanghai Stomatological Hospital
2025
Shenyang University of Technology
2025
State Key Laboratory for Innovation and Transformation of Luobing Theory
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2018-2024
Shandong University
2014-2024
Treatment strategies targeting tumor-associated macrophages (TAMs) have been proposed in cancer areas. The functional alterations of the microenvironment during tumorigenesis human epithelial remain poorly understood. Here, we explored phenotypic alteration development oral squamous cell carcinoma (OSCC). Conditioned media (CM) and exosome supernatants were harvested from normal epithelium, leukoplakia cells OSCC cells. We measured using flow cytometry, luminex assays, quantitative real-time...
Abstract Background Tumor-associated macrophages (TAMs) have a leading position in the tumor microenvironment. Previously, we demonstrated that M1-like TAMs activated by exosome-transferred THBS1 promote malignant migration oral squamous cell carcinoma (OSCC). However, functional roles and associated molecular mechanisms of need to be further clarified OSCC. Methods Conditioned Media (CM) were harvested from exosome TAMs. We measured behaviors OSCC under treatment CM performing colony...
CD4⁺CD25⁺ regulatory T cells (Tregs) mediate immune suppression and prevent autoimmune disorders. Recently, Tregs were found to present in atherosclerotic lesions play an important role the progression of atherosclerosis. Statins have immunomodulatory properties, effect statins on atherosclerosis depends part their mechanisms. We sought determine whether exhibit plaques peripheral circulation patients with acute coronary syndrome (ACS). In vivo experiment, we induced apolipoprotein...
To explore the potential therapeutic effects of angiotensin(1-7) (Ang(1-7)), an endogenous ligand Mas receptor, on streptozotocin-induced diabetic nephropathy, male Wistar rats were randomly divided into two groups: a control group and model group. After 12 weeks, subgroups for 4-week treatments consisting no-treatment group, small-, moderate-, large-dose Ang(1-7) groups, valsartan plus A779 (antagonist receptor) each with 15 rats. improved renal function, attenuated glomeruli sclerosis,...
Common fragile sites (CFS) are chromosomal regions that exhibit instability during DNA replication stress. Although the mechanism of CFS expression has not been fully elucidated, one known feature is a severely delayed S-phase. We used an in vitro primer extension assay to examine progression synthesis through various sequences within FRA16D by replicative human polymerases δ and α, with cell-free extracts. found specific cis-acting sequence elements perturb elongation, causing inconsistent...
To test the hypothesis that adoptive transfer of regulatory T cells (Tregs) may dose-dependently inhibit formation angiotensin II–induced abdominal aortic aneurysm in apolipoprotein E knockout mice, we established an animal model by II infusion mice. Then mice received different treatment with PBS, low-dose Tregs, high-dose or CD25-depleting PC61 antibody. Histopathologic analysis showed incidence was 80%, 76%, 27%, and 71% groups, respectively. Tregs markedly decreased macrophage CD4 +...
Objective— To test the hypothesis that chronic infusion of angiotensin-(1–7) [Ang-(1–7)] may dose-dependently inhibit atherosclerotic lesion formation by targeting vascular smooth muscle cells and a large dose Ang-(1–7) stabilize mature plaque macrophages. Approach Results— In vivo, effects on atherogenesis stability were observed in ApoE −/− mice fed high-fat diet angiotensin II infusion. vitro, cells’ proliferation migration, macrophage inflammatory cytokines examined. attenuated early...
COVID-19 has been a global health threat. We aimed to investigate the nutrition status of patients and evaluate prognostic value controlling nutritional (CONUT) score in these patients. 348 severe with were collected. Based on CONUT score, 161 (46.3%) had mild malnutrition while 139 (39.9%) moderate-severe malnutrition. Compared normal groups, group older, more male, higher counts white blood cell neutrophil as well serum levels C-reactive protein. Nearly half (44.6%) developed acute cardiac...
Induction chemotherapy in oral squamous cell carcinoma is a controversial issue clinical practice. To investigate the evolution of cancer cells and tumor microenvironment (TME) response to carcinoma, single-cell transcriptome analysis was performed post-chemotherapy located cavity. The main types were identified based on gene expression patterns determined using dimensionality reduction unsupervised clustering. Non-negative matrix factorization clustering Cancer-associated fibroblasts (CAFs)...
ABSTRACT Background This study aimed to investigate potential cellular senescence inhibitory genes (CSIGs) and discover novel therapeutic targets in head neck squamous cell carcinoma. Methods Dysregulated CSIGs were identified based on The Cancer Genome Atlas (TCGA) the Human Aging Genomic Resources (HAGR) database. Prognostic value immune infiltration assessed through bioinformatic analysis. Cell proliferation was evaluated using CCK‐8, Edu assay, colony formation assays vitro. Western...
Digital twin technology is crucial in breaking through the bottleneck of integrating physical and information worlds manufacturing industry. However, enterprises lack sufficient economic motivation subjective willingness to adopt due concerns about technological challenges cost inputs. To elucidate mechanisms that influence adoption digital technology, this study establishes an evolutionary game model from a stakeholder perspective, dynamically analyzes strategy selection system stability...
Cryptogenic stroke constitutes approximately 40% of ischemic strokes in young adults, imposing a significant socioeconomic burden. However, the source embolus has been specifically investigated few number studies. In this report, We document first case cryptogenic associated with pulmonary arteriovenous fistula (PAVF), providing evidence mural thrombus formation within PAVF vessel. A 52-year-old woman present sudden-onset blurriness, right-sided numbness and paresthesia, speech difficulties,...
Diabetic cardiomyopathy is a notable microvascular complication of diabetes, characterized primarily by myocardial fibrosis and functional abnormalities. Long-term hyperglycemia induces excessive activation recruitment immune cells triggers the cascade inflammatory responses, resulting in systemic local cardiac inflammation. Emerging evidence highlights significant roles immunology modulating pathology diabetic cardiomyopathy. As primary effectors reactions, are consistently present tissue...
Abstract Congenital heart disease (CHD) is a structural abnormality of the and/or great vessels and patients with CHD are at an increased risks various morbidities throughout their lives reduced long‐term survival. Eventually, may result in complications including failure, arrhythmias, stroke, pneumonia, sudden death. Unfortunately, exact etiology pathophysiology some remain unclear. Although quality life prognosis have significantly improved following technological advancement, influence...
Abstract CD4 + CD25 regulatory T cells (Tregs) have been shown to protect against the development of abdominal aortic aneurysm (AAA). Cyclooxygenase‐2 (COX‐2), a pro‐inflammatory protein, can convert arachidonic acid into prostaglandins (PGs). The present study was aimed investigate effect Tregs on COX‐2 expression in angiotension II (Ang II)‐induced AAA ApoE −/− mice. were injected via tail vein every 2 weeks. Ang continuously infused by micropump for 28 days induce AAA. In vivo, compared...
Angiotensin IV (Ang IV), as an effector peptide of the rennin-angiotensin system, possesses many biological properties yet not completely known. In this study, we aimed to investigate role Ang in development II-induced abdominal aortic aneurysm (AAA) apolipoprotein E-knockout mice. We used II infusion induce AAA, and animals were treated with (1.44 mg/kg per day) plus no treatment, low-, medium-, high-dose (0.72, 1.44, 2.88 day, respectively). The incidence AAA was 87.5%, 66.7%, 37.5%, 83.3%...