A5084962998- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- S100 Proteins and Annexins
- Neurofibromatosis and Schwannoma Cases
- Traumatic Brain Injury and Neurovascular Disturbances
- Tumors and Oncological Cases
- Sarcoma Diagnosis and Treatment
- Soft tissue tumor case studies
- Vascular Malformations and Hemangiomas
- Circular RNAs in diseases
- Renal and related cancers
- MicroRNA in disease regulation
- Retinal and Optic Conditions
- Immune cells in cancer
Shanghai Jiao Tong University
2024-2025
Shanghai Ninth People's Hospital
2024-2025
Shanghai Stomatological Hospital
2025
National Clinical Research
2024
Affiliated Eye Hospital of Wenzhou Medical College
2024
Wenzhou Medical University
2024
Wright State University
2018
ABSTRACT Background This study aimed to investigate potential cellular senescence inhibitory genes (CSIGs) and discover novel therapeutic targets in head neck squamous cell carcinoma. Methods Dysregulated CSIGs were identified based on The Cancer Genome Atlas (TCGA) the Human Aging Genomic Resources (HAGR) database. Prognostic value immune infiltration assessed through bioinformatic analysis. Cell proliferation was evaluated using CCK‐8, Edu assay, colony formation assays vitro. Western...
The immune evasion is one major challenge for cancer immunotherapy. Despite considerable advancements in checkpoint blockade (ICB) therapies the advanced non-small cell lung (NSCLC) patients, only a minority of patients receive long-term survival benefit. Here, this work demonstrates that lysine methyltransferase 5C (KMT5C) crucial promoter NSCLC progression and evasion. This first observes upregulation KMT5C correlated with poor patient prognosis. Notably, knockdown cells suppress tumor...