A5064505837- Reconstructive Surgery and Microvascular Techniques
- Reconstructive Facial Surgery Techniques
- Head and Neck Cancer Studies
- Head and Neck Surgical Oncology
- Immune cells in cancer
- Sarcoma Diagnosis and Treatment
- Neurofibromatosis and Schwannoma Cases
- Facial Nerve Paralysis Treatment and Research
- Trauma Management and Diagnosis
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Oral and Maxillofacial Pathology
- Cardiac tumors and thrombi
- Soft tissue tumor case studies
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Orthopaedic implants and arthroplasty
- Cancer Immunotherapy and Biomarkers
- Oral health in cancer treatment
- Hippo pathway signaling and YAP/TAZ
- Bone Tissue Engineering Materials
- Cancer Cells and Metastasis
- Ear and Head Tumors
- Vascular Tumors and Angiosarcomas
- Oropharyngeal Anatomy and Pathologies
Shanghai Ninth People's Hospital
2015-2025
Shanghai Jiao Tong University
2015-2025
Shanghai Stomatological Hospital
2025
Stomatology Hospital
2025
National Clinical Research
2024
National Clinical Research Center for Digestive Diseases
2021
RELX Group (United States)
2016
Philadelphia University
2016
Abstract Background Tumor-associated macrophages (TAMs) have a leading position in the tumor microenvironment. Previously, we demonstrated that M1-like TAMs activated by exosome-transferred THBS1 promote malignant migration oral squamous cell carcinoma (OSCC). However, functional roles and associated molecular mechanisms of need to be further clarified OSCC. Methods Conditioned Media (CM) were harvested from exosome TAMs. We measured behaviors OSCC under treatment CM performing colony...
Induction chemotherapy in oral squamous cell carcinoma is a controversial issue clinical practice. To investigate the evolution of cancer cells and tumor microenvironment (TME) response to carcinoma, single-cell transcriptome analysis was performed post-chemotherapy located cavity. The main types were identified based on gene expression patterns determined using dimensionality reduction unsupervised clustering. Non-negative matrix factorization clustering Cancer-associated fibroblasts (CAFs)...
ABSTRACT Background This study aimed to investigate potential cellular senescence inhibitory genes (CSIGs) and discover novel therapeutic targets in head neck squamous cell carcinoma. Methods Dysregulated CSIGs were identified based on The Cancer Genome Atlas (TCGA) the Human Aging Genomic Resources (HAGR) database. Prognostic value immune infiltration assessed through bioinformatic analysis. Cell proliferation was evaluated using CCK‐8, Edu assay, colony formation assays vitro. Western...
Tumor-associated macrophages (TAMs) in the tumor microenvironment (TME) widely participate malignant progression cancer. Previously, we have demonstrated that M1-like TAMs cascaded a stem-like phenotype of oral squamous cell carcinoma (OSCC). Yet, underlying mechanisms still need to be for regulation on cancer stem cells (CSCs) OSCC. In this study, investigated group CSCs with increased expression cluster differentiation 10 (CD10), which acted as mediator interaction network between and...
The objective of this study is to evaluate our 10-year clinical experience in surgical management patients with osteoradionecrosis (ORN) unresolved conservative nonoperative treatment.The medical records 120 who had been surgically treated for ORN during a period (January 2003 January 2013) were retrospectively reviewed.The most predilection site was mandible (82.5%), followed by the maxilla (11.7%). developed within initial 12 months 39.2% and first 3 years 68.3%. median radiation dose 68.1...
Objectives: IFNα can stimulate an antitumor immune response and has a direct inhibition on cancer cells.This study is to test whether activate dormant stem cell (CSC) in oral squamous carcinoma (OSCC) facilitate their elimination by chemotherapy.Materials methods: Nude mouse transplantation tumor model was established administrated with saline.The influence CD44 ALDH1A1 expression under treatment detected vivo experiments.Flow cytometry, western blot, immunofluorescence were used detect the...
Background: Targeted therapy of Neurofibromatosis type 1 (NF1) related plexiform neurofibroma (pNF) aiming at MEK molecule has not demonstrated a convincing result for complete disease inhibition, probably due to other signal pathways crosstalk. Our previous study revealed an increased nuclear translocation YAP in NF1 pNF. Herein, we decided further investigate the therapeutic relations interference during treatment against Methods: By means selumetinib (MEK-inhibitor), RNA-sequencing was...
The highly immunosuppressive nature of head–neck squamous cell cancer (HNSCC) is not fully understood. Exosomes play crucial roles in the communication between and non-cancer cells, but clinical significance expression exosome-related genes (ERGs) remains unclear HNSCC. This study aimed to establish an HNSCC-ERGs model by using mass spectrometry (MS)-based label-free quantitative proteomics combination with TCGA primary HNSCC dataset. managed classify patients into two subtypes based on...
Bronchogenic cysts (BCs) are rare congenital cystic lesions arising as a development malformation in the trachea‑bronchial system during embryonic period. The mostly occur mediastinum, with an extremely low morbidity rate oromaxillofacial‑head and neck region. age distribution of patients who present BCs shows significant predominance towards young individuals compared elderly. current study reports case 70‑year‑old female presented painful mass right cervical Pre‑operative computed...
BACKGROUND:This study explored the effects of nano-hydroxyapatite/polyetheretherketone (n-HA/PEEK)- coated sandblasted, large-grit, and acid-etched (SLA) implants on inflammatory cytokines osseointegration in peri-implantitis model beagle dogs. MATERIAL AND METHODS:Peri-implantitis models were established. Eight dogs randomly evenly assigned into SLA tied, + n-HA/PEEK untied, or untied groups. A special periodontal probe was used to detect plaque index (PLI), probing depth (PD), modified...
This study aims to evaluate the expression profile and clinical value of S100 family in head neck squamous cell carcinoma (HNSCC).The patterns, clinicopathological features, prognostic significance underlying correlations genes HNSCC were determined by bioinformatics analysis with application several databases, including The Cancer Genome Atlas (TCGA) Oncomine for differential gene (DEG) analysis, a series tools, Database Annotation, Visualization Integrated Discovery (DAVID), cBioPortal,...