A5103203444- Head and Neck Cancer Studies
- Oral health in cancer treatment
- Cholinesterase and Neurodegenerative Diseases
- Bone and Joint Diseases
- Oral Health Pathology and Treatment
- Alzheimer's disease research and treatments
- Reconstructive Surgery and Microvascular Techniques
- Nicotinic Acetylcholine Receptors Study
- Lung Cancer Treatments and Mutations
- Phytochemicals and Antioxidant Activities
- NF-κB Signaling Pathways
- Tea Polyphenols and Effects
- Free Radicals and Antioxidants
- Ovarian cancer diagnosis and treatment
- Osteomyelitis and Bone Disorders Research
- Cancer Immunotherapy and Biomarkers
- Genetic factors in colorectal cancer
- Facial Trauma and Fracture Management
- Orthopedic Infections and Treatments
- Cytokine Signaling Pathways and Interactions
- Immunodeficiency and Autoimmune Disorders
- Ovarian function and disorders
- Telomeres, Telomerase, and Senescence
- Glioma Diagnosis and Treatment
- Dermatological and Skeletal Disorders
China Pharmaceutical University
2021-2023
Shanghai Jiao Tong University
2007-2019
Guangzhou University of Chinese Medicine
2018
Shanghai Ninth People's Hospital
2003-2017
Shanghai First Maternity and Infant Hospital
2010-2012
Columbia University
2005
Tibetan tea (Kangzhuan) is an essential beverage of the people. In this study, a lyophilized aqueous extract (LATT) was prepared and analyzed by HPLC. The results suggested that there were at least five phenolic components, including gallic acid, four catechins (i.e., (+)-catechin, (-)-catechin gallate (CG), (-)-epicatechin (ECG), (-)-epigallocatechin gallate). Gallic catechins, LATT then comparatively investigated antioxidant assays: ferric reducing power,...
Concomitant inhibition of butyrylcholinesterase (BChE) and histone deacetylase 6 (HDAC6) is supposed to be effective in the treatment Alzheimer's disease (AD). Inspired by our previous efforts designing BChE inhibitors, herein, selective HDAC6 dual inhibitors were successfully identified through fusion core pharmacophoric moiety inhibitors. After structure-activity relationship (SAR) studies, two compounds (24g 29a) confirmed have superior inhibitory activity against (the IC50 hBChE are 4.0...
Comprehensive Summary Butyrylcholinesterase (BChE) is regarded as a promising target for the treatment of Alzheimer's disease (AD), its level significantly increases along with progress this disease. Therefore, development potent and high‐affinity small‐molecule BChE inhibitors may be new strategy discovery anti‐AD drugs. However, current Ellman's method unable to evaluate affinity compounds BChE, has few deficiencies in drug development. Herein, first fluorescence polarization (FP) probes...
Searchable abstracts of presentations at key conferences on calcified tissues ISSN 2052-1219 (online)
The leukocyte immunoglobulin (Ig)-like receptors (LILRs) are constituted by five inhibitory subpopulations (LILRB1-5) and six stimulatory (LILRA1-6). LILR populations substantially reside in immune cells, especially myeloid functioning as a regulator immunosuppressive immunostimulatory responses, during which the nonclassical major histocompatibility complex (MHC) class I molecules widely involved. In addition, LILRs also distributed certain tumor implicated malignancy progression....