A5100387531- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Cardiac electrophysiology and arrhythmias
- Blood Coagulation and Thrombosis Mechanisms
- CAR-T cell therapy research
- Adipokines, Inflammation, and Metabolic Diseases
- Ion channel regulation and function
- vaccines and immunoinformatics approaches
- Immune responses and vaccinations
- Cancer, Stress, Anesthesia, and Immune Response
- Radiomics and Machine Learning in Medical Imaging
- Inflammatory Biomarkers in Disease Prognosis
- Ferroptosis and cancer prognosis
- T-cell and B-cell Immunology
- Epigenetics and DNA Methylation
- Colorectal Cancer Treatments and Studies
- Adipose Tissue and Metabolism
- Venous Thromboembolism Diagnosis and Management
- Cytokine Signaling Pathways and Interactions
- Antiplatelet Therapy and Cardiovascular Diseases
- Lung Cancer Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Hemophilia Treatment and Research
- Lung Cancer Treatments and Mutations
First Affiliated Hospital of Xi'an Jiaotong University
2022-2025
Zhengzhou Fruit Research Institute
2022-2024
Chinese Academy of Agricultural Sciences
2022-2024
Huazhong University of Science and Technology
2013-2023
Qilu Hospital of Shandong University
2022-2023
Tianjin Medical University
2014-2023
Sun Yat-sen University
2012-2023
Sun Yat-sen University Cancer Center
2023
Tianjin Third Central Hospital
2019-2023
Renmin Hospital of Wuhan University
2022
Extracellular vesicles (EVs) are potential alternatives for mesenchymal stem cells (MSCs) in the treatment of musculoskeletal degenerative diseases, including intervertebral disc degeneration (IDD). Usually, EVs internalized and then deliver bioactive molecules that impart phenotypic changes recipient cells. For effective utilization IDD therapy, understanding mechanism EV uptake is vital importance. In this study, we found delivered antioxidant proteins to protect against pyroptosis nucleus...
Abstract Activated T cells polarize mesenchymal stromal (MSCs) to a proinflammatory Th1 phenotype which likely has an important role in amplifying the immune response tumor microenvironment. We investigated of interferon gamma (IFN-γ) and necrosis factor alpha (TNF-α), two factors produced by activated cells, MSC polarization. Gene expression culture supernatant analysis showed that TNF-α IFN-γ stimulated MSCs expressed distinct sets factors. The combination was synergistic induced...
Abstract Background In the evaluation of PD-L1 expression to select patients for anti-PD-1/PD-L1 treatment, uniform guidelines that account different immunohistochemistry assays, cell types and cutoff values across tumor are lacking. Data on how scoring methods compare in breast cancer scant. Methods Using FDA-approved 22C3 diagnostic assay, we retrospectively evaluated 496 primary invasive tumors were not exposed treatment compared three (TC: cells; IC: tumor-infiltrating immune TCIC: a...
Background: Gastric cancer remains the second leading cause of cancer-related death, and third in mortality due to lack effective therapeutic targets for late stage patients. This study aims identify potential druggable target biomarkers as options patients with gastric cancer. Methods: Immunohistochemistry human tumor tissues was conducted determine expression level cyclin-dependent kinase 12 (CDK12). Multiple vitro vivo assays such RNAi, mass spectrometry, computer docking models, assays,...
With the aim to establish a structure-inhibitory activity relationship of flavonoids against dipeptidyl peptidase-4 (DPP-4) and elucidate interaction mechanisms between them, pannel 70 structurally diverse was used evaluate their inhibitory activities DPP-4, among which myricetin, hyperoside, narcissoside, cyanidin 3-O-glucoside, isoliquiritigenin showed higher in concentration-dependent manner. Structure-activity analysis revealed that introducing hydroxyl groups C3', C4', C6 flavonoid...
Bile acid metabolism plays a crucial role in maintaining the delicate balance between coagulation and anticoagulation processes. However, there is paucity of research exploring relationship serum total bile acids (TBA) levels risk deep venous thrombosis (DVT) Chinese individuals. The primary objective this study to investigate association TBA DVT occurrence population. A cross-sectional was conducted involving 4522 patients with suspected DVT, recruited from June 2018 October 2023, at First...
Objective: This research sought to assess the predictive potential of inflammation-immunity-nutrition score (IINS) and high-sensitivity C-reactive protein-albumin-lymphocyte (CALLY) index in individuals with NSCLC post-surgery. Methods: The study enrolled 506 patients undergoing R0 resection at First Affiliated Hospital Xi'an Jiaotong University. training cohort was analyzed utilizing X-tile software identify ideal threshold values for categorizing protein, albumin, lymphocyte count, CALLY...
Estrogen stimulation promotes epithelial cell proliferation in estrogen receptor (ERα)-positive breast cancer. Many ERα target genes have been enumerated, but the identities of key effectors mediating signal remain obscure. During mouse mammary gland development, growth factor (EGFR) ligand amphiregulin acts as an important stage-specific effector signaling. In this study, we investigated role cancer using human tissue samples and tumor xenografts mice. Amphiregulin was enriched ERα-positive...
Recently, inhibiting the PD-1/PD-L1 checkpoint pathway utilizing anti-PD-1 or anti-PD-L1 antibodies has achieved great clinical success in cancer treatment. However, immunotherapy cannot be applied to all patients, no more than 25% showed a positive response. Immunohistochemistry (IHC) is gold standard determine PD-L1 expression level malignant lesions, but noninvasive imaging-meditated strategy urgently required for diagnosis cover shortcomings of invasive techniques. MX001, which an...
The morbidity and mortality of patients with ischemic cardiomyopathy resulted from ischemia/reperfusion injury are very high. present study investigates whether our previously synthesized water-soluble phosphate prodrug acacetin was cardioprotective against in an vivo rat model. We found that intravenous administration (10 mg/kg) decreased the ventricular arrhythmia score duration, reduced fibrillation infarct size, improved impaired heart function induced by myocardial anesthetized rats....
Prospective studies of antibodies to multiple Epstein-Barr virus (EBV) proteins and EBV neutralizing in the same individuals before, during, after primary infection have not been reported. We studied antibody responses college students who acquired during prospective surveillance correlated kinetics response with severity disease. Neutralizing enzyme-linked immunosorbent assay (ELISA) gp350, major target antibody, reached peak levels at medians 179 333 days onset symptoms infectious...
Circulating immune cells influence the efficacy of cancer therapy. This study aimed to investigate prognostic values different peripheral blood leukocyte (PBL) biomarkers in non-small lung (NSCLC) patients treated with chemoradiotherapy.An independent cohort 176 stage III NSCLC who were diagnosed at Shanghai Pulmonary Hospital and Zhejiang Cancer between April, 2010, September, 2018, had available pretreatment tests was enrolled. The all concurrent or sequential chemoradiotherapy according...
Browning white adipocytes may be a new target in anti-obesity therapy. Pentamethylquercetin (PMQ) has been shown to have effects monosodium glutamate-induced obese mice. Here, we aimed study the of PMQ vitro and vivo determine if adipose browning is involved mechanism underlying PMQ. We evaluated on cell proliferation, differentiation, glucose consumption, cellular lipid metabolism, related brown gene expression 3T3-L1 adipocytes. also investigated mouse model high-fat diet (HFD)-induced...
Monocytes/macrophages response plays a key role in post-infarction inflammation that contributes greatly to ventricular remodelling and cardiac rupture. Therapeutic targeting of the GABAA receptor, which is enriched monocytes/macrophages but not expressed myocardium, may be possible after myocardial infarction (MI). After MI was induced by ligation coronary artery, C57BL/6 mice were intraperitoneally administered with one specific agonist or antagonist receptor (topiramate bicuculline),...
Abstract Background Obesity confers increased risk for various types of cancer. PD-L1 is a key molecule in tumor immune evasion by inducing T cell exhaustion. The relationship between obesity and still ambiguous. This study was designed to reveal the development hepatocellular carcinoma melanoma obese mice investigate if adipocytes regulate expression underlying mechanism. Methods Monosodium glutamate-induced were inoculated with H22 cells High fat diet (HFD)-induced B16-F1 mouse cells....