A5101490677- Cancer-related molecular mechanisms research
- Inflammasome and immune disorders
- Circular RNAs in diseases
- Antiplatelet Therapy and Cardiovascular Diseases
- Spine and Intervertebral Disc Pathology
- MicroRNA in disease regulation
- Medical Imaging and Analysis
- Gout, Hyperuricemia, Uric Acid
- Spinal Fractures and Fixation Techniques
- Plant Gene Expression Analysis
- Gut microbiota and health
- Atrial Fibrillation Management and Outcomes
- Lipoproteins and Cardiovascular Health
- Microbial Community Ecology and Physiology
- RNA Research and Splicing
- Lysosomal Storage Disorders Research
- Sarcoma Diagnosis and Treatment
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Signaling Pathways in Disease
- Microbial Fuel Cells and Bioremediation
- Cell Adhesion Molecules Research
- Estrogen and related hormone effects
- Phytochemicals and Antioxidant Activities
- Inflammatory Bowel Disease
- Hydrogen's biological and therapeutic effects
First Affiliated Hospital of Xi'an Jiaotong University
2022-2025
Shanghai First People's Hospital
2024
Shanghai Jiao Tong University
2018-2024
Anhui Agricultural University
2024
Chaohu University
2024
Xi'an Jiaotong University
2023
Guangxi Academy of Agricultural Science
2023
Ministry of Agriculture and Rural Affairs
2023
Second Xiangya Hospital of Central South University
2021
Central South University
2021
Abstract Pyroptosis, a type of Gasdermin-mediated cell death, contributes to an exacerbation inflammation. To test the hypothesis that GSDME-mediated pyroptosis aggravates progression atherosclerosis, we generate ApoE and GSDME dual deficiency mice. As compared with control mice, −/− /ApoE mice show reduction atherosclerotic lesion area inflammatory response when induced high-fat diet. Human atherosclerosis single-cell transcriptome analysis demonstrates is mainly expressed in macrophages....
As one of the commonest gynecological malignancies in world, cervical cancer brings great threat for public health. Long non-coding RNAs (LncRNAs) have been proved to be closely related progression various cancers, including cancer. a tumor promoter, lncRNA XIST has reported malignant tumors. In this study, we aim explore specific mechanism and biological function At first, expression levels were examined both tissues cell lines with qRT-PCR. was extremely overexpressed lines. Kaplan Meier...
Bisphenol A (BPA) acts as xenoestrogen and has a great impact on disorders of human reproductive system. However, the mechanism through which BPA can affect testicular function remains to be identified. GPR30 is novel membrane estrogen receptor with high-affinity low-capacity binding estrogens. We demonstrated that α (ERα), β (ERβ) well are expressed in mouse spermatocyte-derived GC-2 cells using Real-time PCR. treated different doses found even low inhibit cell growth MTT assay. To make...
GSDMB-mediated pyroptosis facilitates a pro-inflammatory immune microenvironment and needs to be tightly regulated avoid excessive inflammation. Here, we provide evidence that itaconate its cell-permeable derivative 4-octyl (4-OI) can significantly inhibit GSDMB-rendered pyroptotic activity independent of Nrf2. 4-OI interferes proteolytic process GSDMB by directly modifying Cys54, Cys148 Ser212 on granzyme A (GrzA), serine protease site-specifically cleaves the inter-domain linker GSDMB,...
Bile acid metabolism plays a crucial role in maintaining the delicate balance between coagulation and anticoagulation processes. However, there is paucity of research exploring relationship serum total bile acids (TBA) levels risk deep venous thrombosis (DVT) Chinese individuals. The primary objective this study to investigate association TBA DVT occurrence population. A cross-sectional was conducted involving 4522 patients with suspected DVT, recruited from June 2018 October 2023, at First...
Although miR-327 had a protective effect on cardiomyocytes as described previously, the potential mechanism still needs further exploration. The aim of this study was to investigate role and oxidative stress in myocardial ischemia/reperfusion injury (MI/RI) process. Oxidative were detected rat model MI/RI, hypoxia/reoxygenation (H/R), tert-butyl hydroperoxide (TBHP) H9c2 cells. In vitro , downregulation inhibited both H/R- TBHP-induced stress, suppressed apoptosis. Meanwhile, fibroblast...
<sec><strong>BACKGROUND</strong> The neutrophil to lymphocyte ratio (NLR) has been reported as a novel predictor for atherosclerosis and cardiovascular outcomes. This study aimed determine the effects of NLR on long-term clinical outcomes chronic total occlusion (CTO) patients. </sec><sec><strong>METHODS</strong> A 670 patients with CTO who met inclusion criteria were included at end follow-up period. Patients divided into tertiles according their baseline levels admission: low (<i>n</i> =...
Yellow tea (YT), a slightly fermented with unique yellowing process and mellow taste, is becoming widely popular. Currently, the YT includes bud yellow (BYT), small-leaf (SYT), large-leaf (LYT) based on maturity of raw materials. Previous studies have shown that has outstanding potential in preventing metabolic syndrome. However, distinct effects mechanisms different types ulcerative colitis (UC) are still unclear. This study investigated continuous or intermittent intervention three water...
Prostate cancer (PC) is the second greatest cause of deaths globally. PC presents a poor prognosis once it metastasizes. There considerable proof vital epithelial-mesenchymal transition (EMT) functionality in metastasis. Previous studies revealed that melanophilin (MLPH) associated with PC; however, its role remains poorly understood.Bioinformatics analyses were performed. The cellular responses to MLPH knockdown examined HCC cell lines via wound healing assay, migration and invasion Western...
Background: N6-methylandenosine-related long non-coding RNAs (m6A-related lncRNAs) are critically involved in cancer development. However, the roles and clinical significance of m6A-related lncRNAs soft tissue sarcomas (STS) inconclusive, thereby warranting further investigations. Methods: Transcriptome profiling data were extracted from The Cancer Genome Atlas (TCGA) database Genotype-Tissue Expression (GTEx). Consensus clustering was employed to divide patients into clusters Kaplan-Meier...
Background: Increasing evidence has demonstrated that immune-related long non-coding RNAs (irlncRNAs) are critically involved in tumor initiation and progression associated with the prognosis of various cancers. However, their role soft tissue sarcoma (STS) remains significantly uninvestigated. Materials Methods: Gene expression profiles were extracted from The Cancer Genome Atlas (TCGA) Genotype-Tissue Expression (GTEx) for identification irlncRNAs. Univariate analysis modified least...
Pyroptosis is critically associated with cancer initiation and progression, which can be modulated by diverse long noncoding RNAs (lncRNAs). However, the roles of pyroptosis-related lncRNAs in soft tissue sarcomas (STS) are still largely unknown.Our study included a total 259 STS patients extracted from The Cancer Genome Atlas Sarcoma (TCGA-SARC) dataset. Gene expression data fragments per kilobase transcript million mapped reads (FPKM) values were downloaded (TCGA) Genotype-Tissue...
Background and Objectives: Gastric acid reflux is known to be the most important cause of contact granuloma. Therefore, anti-gastric medication has been used as first line treatment although there are other methods such surgery or steroid injections. Actually, role in granuloma not established clearly. The purpose this study was evaluate effectiveness surgical for Materials Methods: We retrospectively reviewed medical records 14 patients who were diagnosed with treated from 2011 July 2016 at...