A5100350689- Circular RNAs in diseases
- Estrogen and related hormone effects
- Glaucoma and retinal disorders
- Acute Ischemic Stroke Management
- Systemic Lupus Erythematosus Research
- Cerebrovascular and Carotid Artery Diseases
- Vascular Malformations Diagnosis and Treatment
- Lipid metabolism and disorders
- Ovarian function and disorders
- Reproductive Biology and Fertility
- Cancer-related molecular mechanisms research
- Maternal and fetal healthcare
- Fetal and Pediatric Neurological Disorders
- Appendicitis Diagnosis and Management
- Vascular anomalies and interventions
- Cerebral Venous Sinus Thrombosis
- Inflammatory Biomarkers in Disease Prognosis
- Advanced MRI Techniques and Applications
- Stroke Rehabilitation and Recovery
- Reproductive Physiology in Livestock
- Congenital Diaphragmatic Hernia Studies
- Intestinal Malrotation and Obstruction Disorders
- Intracerebral and Subarachnoid Hemorrhage Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Prenatal Screening and Diagnostics
Hebei Medical University
2015-2025
Second Hospital of Hebei Medical University
2015-2025
Second Affiliated Hospital of Nanchang University
2025
Nanchang University
2025
Xingtai People's Hospital
2022-2024
First Affiliated Hospital of Zhengzhou University
2024
Zunyi Medical University
2022-2024
Eye & ENT Hospital of Fudan University
2023
Hebei General Hospital
2023
Soochow University
2020-2022
As one of the commonest gynecological malignancies in world, cervical cancer brings great threat for public health. Long non-coding RNAs (LncRNAs) have been proved to be closely related progression various cancers, including cancer. a tumor promoter, lncRNA XIST has reported malignant tumors. In this study, we aim explore specific mechanism and biological function At first, expression levels were examined both tissues cell lines with qRT-PCR. was extremely overexpressed lines. Kaplan Meier...
Gestational diabetes mellitus (GDM) is associated with adverse perinatal outcomes. Screening for GDM and applying adequate interventions may reduce the risk of However, diagnosis depends largely on tests performed in late second trimester. The aim present study was to bulid a simple model predict early pregnancy Chinese women using biochemical markers machine learning algorithm. Data total 4771 pregnant gestation were used fit risk-prediction model. Predictive maternal factors selected...
Congenital thrombotic thrombocytopenic purpura (cTTP) is a microangiopathy (TMA) characterized by severe hereditary ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin type 1 motifs 13) deficiency caused mutations. This rare autosomal recessive genetic disorder often misdiagnosed as immune thrombocytopenia (ITP) or hemolytic uremic syndrome (HUS). Here, we report 21-year-old male cTTP patient compound heterozygous mutation. The was admitted for acute thrombocytopenia, 5-year...
Hepatectomy represents the cornerstone therapeutic approach for intrahepatic cholangiocarcinoma (ICCA); however, research pertaining to prognosis of ICCA patients utilizing competing risk models remains scarce. This study aimed construct a prognostic model analysis predict cancer-specific survival (CSS) among posthepatectomy. retrospectively analyzed from Surveillance, Epidemiology, and End Results (SEER) database (2004-2015) who underwent hepatectomy. Patients were randomly allocated...
Purpose: Surgery impairs immune function and increases postoperative complications. B7H3, a co-stimulatory molecule, plays crucial role in regulation. The present study examined the impact of B7H3 on response children with acute suppurative appendicitis (ASA) by comparing preoperative levels laparoscopic surgery (LA) open appendectomy (OA). Patients Methods: 198 pediatric ASA patients were enrolled. researcher group performed LA, while control OA. Perioperative time, recovery time...
BACKGROUND:Increasing the success rate of in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) is a duty clinicians that has made many seek variety protocols. This study was undertaken to use liquid chromatography-mass spectrometry (LC-MS) define alterations follicular fluid (FF) lipid metabolites patients undergoing progestin-primed ovarian stimulation (PPOS) compared with short-term protocol, revealing potential correlations between differentially expressed lipids and...
Abstract This study was to quantitatively investigate the role of morphological and functional parameters left atrium (LA) atrial appendage (LAA) with 256-slice spiral computed tomography (CT) in recurrence fibrillation (AF) after radiofrequency ablation (RFA). Eighty-three patients AF who underwent RFA for first time were divided into (n = 27) non-recurrence 56) groups. All a CT examination before operation. The clinical data quantitative measurement morphology LA LAA analyzed, including...
Cardiac toxicity has been the major concern when using doxorubicin (DOX) in cancer therapy. Thrombopoietin (TPO) protects cardiac cells from DOX-induced cell damage; however, its molecular mechanism remains exclusive. The anti-autophagic and anti-apoptotic effects of TPO upon DOX treatment were studied H9C2 line, with bafilomycin A1 as a positive control for autophagy inhibition. Cell viability was measured by Counting Kit-8 assay different groups. mRNA and/or protein levels apoptotic...
Hepatocellular carcinoma (HCC) is an aggressive malignancy with a poor prognosis. Effective biomarkers and specific therapeutic targets for HCC are therefore urgently needed. G protein-coupled estrogen receptor (GPER) plays crucial role in numerous cancer types; however, its functions require further exploration. In the present study, we found remarkable difference GPER staining between tumor tissue (100/141, 70.9%) matched non-tumor (27/30, 90.0%). Compared GPER-negative patients,...
This study aimed to assess the effects of human urinary kallidinogenase (HUK) on motor function outcome and corticospinal tract recovery in patients with acute ischemic stroke (AIS). was a randomized, controlled, single-blinded trial. Eighty AIS were split into two groups: HUK control groups. The group administered standard treatment, while received treatment only. At admission discharge, National Institutes Health Stroke Scale (NIHSS), Barthel Index (BI) muscle strength scored. primary...
Mantle cell lymphoma (MCL) is an aggressive form of non-Hodgkin’s B-cell with poor prognosis. Despite recent advances, resistance to therapy and relapse remain significant clinical problems. G-protein-coupled estrogen receptor (GPER)-mediated estrogenic rapid signaling implicated in the development many cancers. However, its role MCL unknown. Here we report that GPER activation selective agonist G-1 induced cycle arrest, DNA damage, mitochondria membrane potential abnormality, eventually...
Hemophilia A and B are hereditary coagulation defects resulting in unstable blood clotting recurrent bleeding. Current factor replacement therapies have major limitations such as the short half-life of factors development inhibitors. Alternative approaches to rebalance hemostasis by inhibiting anticoagulant pathways recently gained considerable interest. In this study, we tested therapeutic potential a monoclonal antibody, HAPC1573, that selectively blocks activity human activated protein C...
Although diagnosis and treatment of gastric cancer have improved, the prognosis patients remains poor. The majority should be treated with chemotherapy or other follow-up treatment. However, drug resistance heterogeneity tumor itself lead to differences sensitivity drugs for different patients. Therefore, it is mandatory develop better methods cancer. Calycosin has been used in several types cells. Cisplatin, 5-fluorouracil (5-FU), adriamycin (ADM) are most widely chemotherapy, they improve...
The present study evaluated the value of black-blood high-resolution magnetic resonance imaging (HRMRI) for visualization intracranial atherosclerosis (ICAS) plaques. A total 110 patients with cerebral artery or vertebrobasilar stenosis, vessel occlusion a significantly weakened signal in angiography (MRA; three-dimensional time-of-flight) were examined. Black-blood MRA was used to observe whether plaques abnormal vascular walls. Among infarction, 16 cases presented no significant...
Abstract Objectives Central nervous system vasculitis (CNSV) is a rare disease. High-resolution vessel wall imaging (HR-VWI) enables the identification of inflammatory changes within wall. Few studies have applied HR-VWI to assess CNSV in children. This study delves into utility for diagnosing and treating children, with aim enhancing clinical diagnosis efficacy evaluation. Methods Imaging data were acquired from children who underwent examinations. The meticulously analysed laboratory tests...
To investigate the factors associated with brain frailty and effect of in patients anterior circulation large artery occlusion (AC-LAO).
Objectives This study aims to discuss the clinical manifestations and treatment of Familial hemophagocytic lymphohistiocytosis (FHL) caused by a mutation in UNC13D gene. Methods A 6-year-old female child presented with unexplained febricity, splenomegaly, pancytopenia, bone marrow, decreased NK cell activity, soluble CD25 levels > 44000ng/ml. Genetic sequencing revealed Additionally, patient experienced intermittent fever seizures characterized involuntary twitching left upper limb....
Objectives: Patients with anterior circulation large vessel occlusion are at high risk of acute ischemic stroke, which could be disabling or fatal. In this study, we applied machine learning to develop and validate two prediction models for stroke (Model 1) severity neurological impairment 2), both caused by (AC-LVO), based on medical history neuroimaging data patients admission. Methods: A total 1,100 AC- LVO from the Second Hospital Hebei Medical University in North China were enrolled,...
To describe labor progression patterns with oxytocin for augmentation in women who achieve vaginal delivery; and to determine how long one should wait effective uterine contraction before arrest can be diagnosed.Population-based retrospective cohort study.The final sample involved 8,988 singleton gestation, term live birth, vertex presentation, no previous cesarean section, delivery, neonatal Apgar score at 5 minutes 7 or higher, complete information on 2005-2007.Linear interpolation was...