A5007318688- Heavy Metal Exposure and Toxicity
- Trace Elements in Health
- Birth, Development, and Health
- Nutritional Studies and Diet
- Obesity, Physical Activity, Diet
- Bone health and osteoporosis research
- Body Composition Measurement Techniques
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Epigenetics and DNA Methylation
- Cardiovascular Health and Risk Factors
- Cardiovascular Disease and Adiposity
- Nutrition and Health in Aging
- Iron Metabolism and Disorders
- Cancer Cells and Metastasis
- Blood Pressure and Hypertension Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Bone Tumor Diagnosis and Treatments
- Sarcoma Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Liver Disease Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Heavy metals in environment
- Air Quality and Health Impacts
- Tumors and Oncological Cases
- Public Health and Nutrition
Neurocrine Biosciences (United States)
2024-2025
China Academy of Engineering Physics
2025
Capital Institute of Pediatrics
2015-2024
Guangxi Medical University
2012-2024
Wuhan University
2011-2024
University of Electronic Science and Technology of China
2024
Zhongnan Hospital of Wuhan University
2024
Albert Einstein College of Medicine
2023
Xi'an Jiaotong University
2022-2023
West Virginia University
2023
Acquired tamoxifen resistance remains the major obstacle to breast cancer endocrine therapy. β1-integrin was identified as one of target genes G protein-coupled estrogen receptor (GPER), a novel recognized an initiator resistance. Here, we investigated role in GPER-mediated cancer.The expression and biomarkers epithelial-mesenchymal transition were evaluated immunohistochemically 53 specimens metastases paired primary tumors. The function tamoxifen-resistant (MCF-7R) subclones, derived from...
IκB kinase (IKK) β is essential for inflammatory cytokine-induced activation of nuclear factor κB (NF-κB). NF-κB plays a pivotal role in the function major cell types that contribute to pathophysiological process rheumatoid arthritis (RA). Here, we report mechanism and effect IKKβ inhibitor <i>N</i>-(6-chloro-7-methoxy-9<i>H</i>-β-carbolin-8-yl)-2-methylnicotinamide (ML120B), β-carboline derivative, on signaling gene RA-relevant systems. ML120B potent, selective, reversible, ATP-competitive...
Breast cancer adversely affects the health status of women; therefore, prevention and treatment breast is critical importance.Lycopene known to possess several biological effects such as removal free radicals, alleviation oxidative injury, inhibition tumor growth.In this study, we aimed illustrate effect lycopene on cell proliferation modulation progression well its possible underlying mechanisms in human carcinoma line MCF-7 vitro.MCF-7 cells were treated with different concentrations for...
Sarcopenia is an important indicator of ill health and linked to increased mortality a reduced quality life. Age-associated muscle mass indices provide critical tool help understand the development sarcopenia. This study aimed develop sex- age-specific percentiles for in Chinese population compare those with from other ethnicities using National Health Nutrition Examination Survey (NHANES) data.
Abstract Background: An altered pattern of epigenetic modifications is central to the development and progression various tumors. We studied changes involving multiple histones better predict prognosis glioma patients. Methods: Immunohistochemistry was done investigate global histone modification expression 3 lysine 4 dimethylation (H3K4diMe), arginine monomethylation (H4R3monoMe), 20 trimethylation (H4K20triMe), acetylation 9 (H3K9Ac), 18 (H3K18Ac), 12 (H4K12Ac), 16 (H4K16Ac) in resected...
Abstract Background Although attention to metabolic syndrome (MetS) in children has increased, there is still no universally accepted definition and its pathogenesis remains unclear. Our aim was compare the current definitions of childhood MetS a Chinese cohort examine clustering pattern risk factors, particularly inclusion leptin adiponectin as additional components. Methods 3373 schoolchildren aged 6 18 years were recruited. Anthropometric biochemical parameters adipokines measured....
Serum lipid trends in children and adolescents are predictors of the future prevalence cardiovascular disease adults.Data were obtained from cross-sectional studies conducted 2004 2014. A total 3249 aged 6-18 years included present study; serum cholesterol (TC), high-density lipoprotein (HDL-C), low-density (LDL-C), triglycerides (TG) measured.Overall, upward mean TC, non-HDL-C, LDL-C levels, geometric TG observed (all P < 0.001). Mean HDL-C levels significantly decreased between 2014 (from...
Abstract Background The role of glycolysis in tumorigenesis has received increasing attention and multiple glycolysis-related genes (GRGs) have been proven to be associated with tumor metastasis. Hence, we aimed construct a prognostic signature based on GRGs for clear cell renal carcinoma (ccRCC) explore its relationships immune infiltration. Methods Clinical information RNA-sequencing data ccRCC were obtained from Cancer Genome Atlas (TCGA) ArrayExpress datasets. Key finally selected...
Hereditary non-polyposis colorectal cancer (HNPCC) is a dominantly inherited syndrome caused by germline defects of mismatch repair (MMR) genes. Endometrial the most common extracolonic neoplasm in HNPCC and primary clinical manifestation some families. The cumulative incidence endometrial among mutation carriers high, estimated to be from 22 43%. We hypothesized that women with double cancers colorectum endometrium are likely members In order determine how frequently manifests context...
Aberrant promoter hypermethylation of several known or putative tumor suppressor genes occurs frequently during the malignant transformation in gliomas. We hypothesized that quantitative analysis methylated will provide prognostic values glioma patients. used an immunocapturing approach followed by real-time polymerase chain reaction to detect altered patterns methylation O-6-methylguanine-DNA methyltransferase (MGMT), p16INK4a, tissue inhibitor metalloproteinase-3 (TIMP-3), and...
Summary A genome‐wide association study of serum uric acid (SUA) laevels was performed in a relatively isolated population European descent from an island the Adriatic coast Croatia. The sample included 532 unrelated and 768 related individuals 235 pedigrees. Inflation due to relatedness controlled by using genomic control. Genetic assessed with 2,241,249 single nucleotide polymorphisms (SNPs) 1300 samples after adjusting for age gender. Our replicated four previously reported SUA loci (...
NDR/LATS kinase family is highly conserved from yeast to human. It remains unknown whether the members of this function in innate immune responses. Here we demonstrate that Stk38 negatively regulates TLR9-mediated responses macrophages. constitutively associates with ubiquitin E3 ligase Smurf1, and facilitates Smurf1-mediated MEKK2 ubiquitination degradation. required for CpG-induced ERK1/2 activation, TNF-α IL-6 production but not LPS-induced production. Accordingly, deficiency increases...
Ageing is an inevitable process that affects various tissues and organs of the human body, leading to a series physiological pathological changes. Mechanisms such as telomere depletion, stem cell macrophage dysfunction, cellular senescence gradually manifest in significantly increasing incidence diseases elderly individuals. These mechanisms interact with each other, profoundly impacting quality life older adults. As ageing population continues grow, burden on public health system expected...
Electrocatalytic hydrogenation (ECH) of oxalic acid (OX) as a feedstock to generate glycolic (GC) with high added value has been considered provide viable pathway towards sustainable chemical...