A5037264322- Telomeres, Telomerase, and Senescence
- Epigenetics and DNA Methylation
- Histiocytic Disorders and Treatments
- Lymphoma Diagnosis and Treatment
- Metabolism and Genetic Disorders
- Eosinophilic Disorders and Syndromes
- Renal Diseases and Glomerulopathies
- Potassium and Related Disorders
- Viral-associated cancers and disorders
- Prion Diseases and Protein Misfolding
- Health, Environment, Cognitive Aging
- Neurological diseases and metabolism
- Chronic Lymphocytic Leukemia Research
- Renal and related cancers
- Parvovirus B19 Infection Studies
- Mitochondrial Function and Pathology
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Vascular Malformations and Hemangiomas
- Ferroptosis and cancer prognosis
- S100 Proteins and Annexins
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Heme Oxygenase-1 and Carbon Monoxide
- Bipolar Disorder and Treatment
- Boron Compounds in Chemistry
Peking Union Medical College Hospital
2020-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2025
Institute of Hematology & Blood Diseases Hospital
2023-2024
Daping Hospital
2017-2024
Army Medical University
2017-2024
Heilongjiang University of Chinese Medicine
2024
Chengdu University of Traditional Chinese Medicine
2024
Chongqing Emergency Medical Center
2024
Academy of Medical Sciences
2024
National Institute for Viral Disease Control and Prevention
2019-2023
Abstract Cellular senescence represents an irreversible state of cell-cycle arrest during which cells secrete senescence-associated secretory phenotypes, including inflammatory factors and chemokines. Additionally, these exhibit apoptotic resistance phenotype. serves a pivotal role not only in embryonic development, tissue regeneration, tumor suppression but also the pathogenesis age-related degenerative diseases, malignancies, metabolic kidney diseases. The renal tubular epithelial (RTEC)...
To assess the effects of atomizing inhalation antibiotics on germ clearance rate and adverse reactions in respiratory infectious diseases. Atomizing is an innovative local drug delivery strategy. PubMed, Medline, Web Science were searched systematically for appropriate clinical studies diseases (patients diagnosed with diseases; intervention: antibiotics; comparison: oral or intravenous administration). Basic data recorded: sample size, follow-up time, rate, other outcome indicators. A...
Abstract Plasma cell disorders (PCDs) are marked by the clonal proliferation of abnormal plasma cells and bone marrow (BMPCs), causing various clinical complications. These PCDs include subtypes with distinct features. Multiple myeloma (MM) monoclonal gammopathy undetermined significance (MGUS) more common relatively well-studied. In contrast, primary light-chain amyloidosis (AL) POEMS syndrome (POEMS) rare remain less understood. To investigate role hematopoietic (CH) mutations potential...
Ageing is an inevitable process that affects various tissues and organs of the human body, leading to a series physiological pathological changes. Mechanisms such as telomere depletion, stem cell macrophage dysfunction, cellular senescence gradually manifest in significantly increasing incidence diseases elderly individuals. These mechanisms interact with each other, profoundly impacting quality life older adults. As ageing population continues grow, burden on public health system expected...
Unicentric Castleman disease (UCD) is a rare lymphoproliferative disorder presenting as single nodal mass with characteristic histopathology. Patients UCD are typically asymptomatic normal laboratory markers, whereas patients multicentric (MCD) demonstrate lymphadenopathy and cytokine storm-induced systemic inflammatory symptoms. This retrospective analysis of 116 cases identified 19 (16.4%) an MCD-like state (UCD-MIS). We compared treatments outcomes between UCD-MIS UCD-non-MIS to evaluate...
Abstract Background Langerhans cell histiocytosis (LCH) is a rare highly heterogeneous histiocytosis, which can be divided into single system and multiple disease according to site of involvement. There paucity studies examining unifocal LCH in adults the molecular era. Results We retrospectively analysed records from 70 patients with LCH. The median age at diagnosis was 36 years (18–69). most common organ involved bone (70.0%), followed by pituitary gland (7.1%). Target gene sequencing...
The abnormal alterations of proteins 14-3-3 and tau in cerebrospinal fluid (CSF) are widely used for the diagnosis sporadic Creutzfeldt-Jakob disease (sCJD), while situations CSF biomarkers genetic prion diseases (gPrDs), particularly Chinese gPrDs patients, have not been well documented.Here, with help commercial total ELISA kits, we evaluated levels samples 140 patients 14 different types gPrDs.We found that values P102L GSS D178N FFI were remarkably low, those T188K, E196A, E200K gCJD...
Schwannoma is a generally benign tumor of the peripheral nerve sheath arising from Schwann cells. Most schwannomas are found on head and neck. Here, we describe rare case vulvar schwannoma located at labium majus which was similar to an epidermoid cyst in clinical appearance.
Several mitochondrial DNA mutations have been reported to be associated with nonsyndromic hearing loss in several families. However, little is known about the prevalence of these sporadic patients sensorineural loss.The purpose our study was investigate incidence such population.A total 178 were enrolled this study. Genomic extracted from peripheral blood sample. We employed SNaPshot(®) sequencing method detect five mutations, including A1555G and A827G 12S rRNA gene A7445G, 7472insC, T7511C...
Abstract The causal direction and extent of the link between telomere length, epigenetic age acceleration (EAA), occurrence haematological malignancies benign disorders remain uncertain because inherent susceptibility observational studies to confounding reverse causation. We conducted two-sample single-variable Mendelian randomisation (SVMR) multivariable (MVMR) analyses using summary statistics from genome-wide association (GWAS) explore potential associations among EAA, multiple...
Abstract To elucidate the expression profiles, methylation states, and clinicopathological significance of PRDM gene family, focusing on MECOM gene's role in uterine endometrial cancer (UCEC) its molecular interactions with TGF-beta signaling pathway. Our methodology combined detailed bioinformatics analyses using UALCAN GEPIA vitro assessments HEC-1-A cells. Techniques included CRISPR-Cas9 for editing various cellular assays (CCK-8, flow cytometry, Transwell) to evaluate effects cell...
Background: The causal direction and extent of the link between telomere length, epigenetic age acceleration (EAA), occurrence haematological malignancies benign disorders remain uncertain because inherent susceptibility observational studies to confounding reverse causation.Methods: We conducted two-sample single-variable Mendelian randomisation (SVMR) multivariable (MVMR) analyses using summary statistics from genome-wide association (GWAS) explore potential associations among EAA,...