Abstract Cellular senescence represents an irreversible state of cell-cycle arrest during which cells secrete senescence-associated secretory phenotypes, including inflammatory factors and chemokines. Additionally, these exhibit apoptotic resistance phenotype. serves a pivotal role not only in embryonic development, tissue regeneration, tumor suppression but also the pathogenesis age-related degenerative diseases, malignancies, metabolic kidney diseases. The renal tubular epithelial (RTEC)...

Premature senescence is a key process in the progression of diabetic nephropathy (DN). renal tubular epithelial cells (RTEC) DN may result from accumulation damaged mitochondria. Mitophagy principal that eliminates mitochondria through PTEN-induced putative kinase 1 (PINK1)-mediated recruitment optineurin (OPTN) to We aimed examine involvement OPTN mitophagy regulation cellular RTEC context DN. In vitro, expression markers P16, P21, DcR2, SA-β-gal, SAHF, and insufficient mitophagic...

Tubulointerstitial inflammation plays a critical role in the progression of diabetic nephropathy (DN), and nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasomes contribute to renal interstitial DN. Decreased expression optineurin (OPTN) is also associated with We investigated OPTN activation NLRP3 inflammasome initially examined biopsy tissues 172 patients type 2 DN 32 nondiabetic hamartoma. Expression was significantly lower...

The relationship between intradialytic blood pressure variability (BPV) and mild cognitive impairment (MCI) in maintenance hemodialysis (MHD) patients is currently unclear. Our present study aimed to illustrate the correlation intra-dialysis BPV CI MHD patients. Intradialytic SBP within 3 months before assessment of were collected as baseline data averaged final data. was converted following 4 candidate short-term indices: standard deviation (SD), coefficient variation (CV), average real...

In diabetic kidney disease (DKD), urinary decoy receptor 2 (uDcR2) levels are associated with tubulointerstitial fibrosis; however, whether uDcR2 can predict renal outcomes remains unclear. Herein, we analyzed the association between and (defined as a composite of serum creatinine (SCr) increase 50 % from baseline, or initiation dialysis for end-stage disease) in 153 patients biopsy-proven DKD. Patients were divided into (n = 67) no 86) outcome groups. measured using ELISA. The area under...

Lipoprotein glomerulopathy (LPG), a rare genetic metabolic kidney disease with poor prognosis, is caused by mutations in the apolipoprotein E (ApoE) gene and usually accompanied hyperlipidemia. can be complicated other glomerulopathies, such as membranous nephropathy, lupus nephritis, immunoglobulin A nephropathy (IgAN), which have been mainly reported Japan. Herein, we present first case of patient LPG IgAN from Chongqing, China. In contrast to previous cases, this lacked hyperlipidemia...

Premature senescence of renal tubular epithelial cell (RTEC), which is involved in kidney fibrosis, a key event the progression diabetic nephropathy. However, underlying mechanism remains unclear. Here we investigated role and decoy receptor 2 (DcR2) fibrosis senescent phenotype RTEC. DcR2 was specifically expressed RTEC associated with patients nephropathy mice streptozotocin-induced Knockdown decreased expression α-smooth muscle actin, collagen I, fibronectin serum creatinine levels mice....

Phagocytic clearance of apoptotic cells by the macrophages (efferocytosis) is impaired in sepsis, but its mechanism poorly understood. Extracellular cold-inducible RNA-binding protein (eCIRP) a novel damage-associated molecular pattern that fuels inflammation. We identify eCIRP-induced neutrophil extracellular traps (NETs) impair efferocytosis through mechanism. Coculture and thymocytes presence recombinant murine CIRP (rmCIRP)-induced NETs significantly inhibited efferocytosis....

Stimulator of IFN genes (STING) activates TANK-binding kinase 1 (TBK1) and regulatory factor 3 (IRF3) to produce type I IFNs. Extracellular cold-inducible RNA-binding protein (eCIRP) is released from cells during hemorrhagic shock (HS). We hypothesized that eCIRP STING induce inflammation acute lung injury (ALI) after HS. WT STING-/- mice underwent controlled hemorrhage by bleeding, followed fluid resuscitation. Blood lungs were collected at 4 hours Serum ALT, AST, LDH, IL-6, IFN-β...

Abstract The mechanisms underlying acute kidney injury (AKI) and chronic disease (CKD) progression include interstitial inflammation, cellular senescence, oxidative stress (OS). Although vanin‐1 (VNN1) plays an important role in OS, its contribution to the AKI‐CKD transition remains unknown. Here, we explored roles of VNN1 transition. We observed that expression was upregulated after ischemia/reperfusion (I/R) high levels were associated with poor renal repair I/R injury. In knockout (KO)...

Abstract Background An appropriate prediction model for adverse prognosis before peritoneal dialysis (PD) is lacking. Thus, we retrospectively analysed patients who underwent PD to construct a predictive prognoses using machine learning (ML). Methods A retrospective analysis was conducted on 873 from August 2007 December 2020. total of 824 met the inclusion criteria were included in analysis. Five commonly used ML algorithms initial training. By area under curve (AUC) and accuracy (ACC),...

This study examines two retailer-initiated pre-shipment financing programs to assist capital-constrained suppliers in securing external funds for production. The first program is retailer-sponsored (RSF), an emerging practice developing economies. Under RSF, the retailer commits sharing loan repayment obligation with supplier by agreeing pay up a specific portion of supplier’s bank repayment. second advance payment (AP), common arrangement wherein pays part wholesale amount upfront support...

An excessive inflammatory response is thought to account for the pathogenesis of sepsis and multiple organ dysfunction syndrome (MODS) after severe trauma. The interleukin-10 (IL-10) a potent anti-inflammatory cytokine. objectives this prospective study were investigate distribution IL-10 promoter polymorphisms in cohort 308 Chinese Han patients with major trauma, identify associations production incidence MODS.A total trauma included study. genotypes -1082, -819 -592 determined by...

Toll-like receptor 2 (TLR2) signaling plays a critical role in orchestrating the innate immune response and development of sepsis subsequent organ dysfunction after trauma. The objectives this prospective study were to identify haplotype tag single-nucleotide polymorphisms (htSNPs) within entire TLR2 gene investigate their clinical relevance patients with major A total 410 trauma prospectively recruited. htSNPs was determined using HapMap database linkage disequilibrium analysis. genotyped...

Abstract Background Lung adenocarcinoma (LUAD) is a common subtype of non‐small cell lung cancer with high morbidity and mortality rates usually detected at advanced stages because the early onset metastasis. Adenosine deaminase RNA‐specific 1 (ADAR1) an RNA editing enzyme that catalyzes important physiological process adenosine‐to‐inosine has been shown to participate in progression LUAD. Increasing evidence suggested immune infiltration tumor microenvironment prognostic value for most...

Renal tubular injury contributes to the progression of diabetic nephropathy (DN). This study explored role and mechanisms E3-ubiquitin ligase Parkin in renal DN. We found that expression gradually decreased was inversely associated with IL-6, TGF-β1, GATA4 kidney during over-expression (OE) reduced inflammation, fibrosis, premature senescence epithelial cells (RTECs), improved function while knockout (KO) had opposite effects DN mice. Parkin-OE protein, but not its mRNA transcripts mice high...