A5100436491- Reproductive System and Pregnancy
- Endometriosis Research and Treatment
- Pregnancy and preeclampsia studies
- Cleft Lip and Palate Research
- Neurological diseases and metabolism
- Animal Genetics and Reproduction
- Connective tissue disorders research
- Gynecological conditions and treatments
- Fetal and Pediatric Neurological Disorders
- Nutrition, Genetics, and Disease
- Prenatal Screening and Diagnostics
- Sperm and Testicular Function
- Tissue Engineering and Regenerative Medicine
- Reproductive Biology and Fertility
- Local Government Finance and Decentralization
- Urological Disorders and Treatments
- MicroRNA in disease regulation
- Hypothalamic control of reproductive hormones
- Endometrial and Cervical Cancer Treatments
- Dietary Effects on Health
- Cellular transport and secretion
- China's Socioeconomic Reforms and Governance
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Connexins and lens biology
- Fiscal Policy and Economic Growth
Nanjing Drum Tower Hospital
2020-2023
Animal Science Research Institute
2023
Xinjiang Academy of Agricultural and Reclamation Science
2017-2023
Guangdong Province Women and Children Hospital
2023
Daping Hospital
2022
Army Medical University
2022
National Center for Chronic and Noncommunicable Disease Control and Prevention
2019
First Affiliated Hospital of Zhengzhou University
2016
Chongqing Medical University
2011
Chongqing Public Health Medical Center
2011
Thin endometrium has been widely recognized as a critical cause of infertility, recurrent pregnancy loss, and placental abnormalities; however, access to effective treatment is formidable challenge due the rudimentary understanding pathogenesis thin endometrium. Here, we profiled transcriptomes human endometrial cells at single-cell resolution characterize cell types, their communications, underlying mechanism growth in normal during proliferative phase. Stromal were most abundant type...
Abstract Macrophages are a key and heterogeneous cell population involved in endometrial repair regeneration during the menstrual cycle, but their role development of intrauterine adhesion (IUA) sequential fibrosis remains unclear. Here, we reported that CD301 + macrophages were significantly increased showed most active interaction with profibrotic cells endometria IUA patients compared normal by single‐cell RNA sequencing, bulk experimental verification. Increasing promoted differentiation...
Abstract Epithelial homeostasis plays an essential role in maintaining endometrial function. But the epithelial fibrosis has been less studied. Previously, we showed that ectopic expression of ΔNp63α is associated with process and dysfunction endometria patients intrauterine adhesions (IUAs). Since profoundly involved homeostasis, hereby focused on its roles regulating function phenotype cells (EECs) context fibrosis. We identified a typical type 2 epithelial-to-mesenchymal transition (EMT)...
Abstract The mechanisms underlying acute kidney injury (AKI) and chronic disease (CKD) progression include interstitial inflammation, cellular senescence, oxidative stress (OS). Although vanin‐1 (VNN1) plays an important role in OS, its contribution to the AKI‐CKD transition remains unknown. Here, we explored roles of VNN1 transition. We observed that expression was upregulated after ischemia/reperfusion (I/R) high levels were associated with poor renal repair I/R injury. In knockout (KO)...
Thin endometrium (TE) is a challenging clinical issue in the reproductive medicine characterized by inadequate endometrial thickness, poor response to estrogen and no effective treatments currently. At present, precise pathogenesis of thin endometria remains be elucidated. We aimed explore related molecular mechanism TE comparing transcriptome profiles late-proliferative phase between matched controls.We performed bulk RNA-Seq (RNA-sequencing) tissues 7 controls for first time. Differential...
Severe uterine injury is a major cause of endometrial scar formation and female infertility. At present, the methods for accelerating injured healing are still lacking. Genetic engineering modification mesenchymal stem cells (MSCs) has been shown great promise in preclinical studies on regeneration. Here, we constructed type umbilical cord MSCs (UC-MSCs) with overexpressed basic fibroblast growth factor (UCMSC-bFGF) investigated effects UCMSC-bFGF/scaffold functional regeneration...
Has the reform process in China resulted introduction of incentives directed at a more efficient allocation resources? Using data on individual earnings urban Liaoning province for period 1986–1990 and wage-equation approach, we address this issue context labour-market reforms, focusing specifically returns to education. Our results indicate that failure endogenous selection ‘able’ individuals into state-owned enterprises (SOEs) can severely bias downwards. Unlike SOEs, collective-owned...
Abstract In an attempt to discover novel proteins functioning in both interphase nucleus and mitotic spindle as NuMA does, we carried out cDNA library screening with pooled autoimmune antibodies. Among positive clones found a recently identified transcription regulatory protein (CDCA4) the distinctive nuclear‐mitotic apparatus distribution. CDCA4 localizes at metaphase poles midzone later stages. Additionally, intensive accumulation parallel was observed half of cells but not stages,...
Objective: To understand the control attempts of body weight and its related factors among overweight obese adults in China. Methods: Data was from 2013 Chinese Chronic Diseases Risk Factors Surveillance Program, which covered 302 surveillance sites. 179 570 adults, selected through multistage stratified cluster sampling method, were interviewed. Demographic characteristics weight-control collected via face-to-face interview. BMI, waist circumstance blood pressure individually measured under...
Fetal facial profile could be measured during the early pregnancy. Its abnormalities might associated with certain congenital malformations. We aimed to study associations between fetal measurements crown-rump length and malformations (cleft lip palate, micrognathia, open spina bifida) pregnancy.We performed a prospective cross-sectional June 2019 April 2022. Pregnant women at gestational age 11-13+ 6 weeks were enrolled. Two sonographers independently. The these evaluated.There 406 25...
Abstract Macrophages are a key and heterogeneous cell population involved in endometrial repair regeneration during the menstrual cycle, but their role development of intrauterine adhesion (IUA) sequential fibrosis remains unclear. Here, we reported that CD301+ macrophages were significantly increased showed most active interaction with profibrotic cells endometria IUA patients compared normal by single-cell RNA sequencing, bulk sequencing experimental verification. Increasing promoted...
Ovine somatic cell nuclear transfer (SCNT) efficiency remains lower. Therefore, we optimized the program before oocyte enucleation on ovine SCNT. Four experiments were done including exposure duration of ovaries (3 h or 3 to 5 h), oocytes maturation (18 and 24 rate donor adherent time maturate oocyte. The rates oocyte, fusion cleavation cloned embryos used assess different procedures. with was higher than that (60.18% vs 52.50%) (P<0.05). Embryonic development competence had no significant...
Abstract Background When a fetus was found has cleft lip palate (CL/P) by prenatal anatomical ultrasound assessment, it is difficult to determine the CL/P isolated or companied with other animalities such as intellectual disability. We preformed comprehensive genetic test support counselling for which detected screening. Methods 105 unrelated fetuses were enrolled. After excluding aneuploidy cases, SNP array and clinical exome sequencing (CES) simultaneously. All followed-up. Results Fetuses...
Abstract Background When a fetus was found has cleft lip palate (CL/P) by prenatal anatomical ultrasound assessment, it is difficult to determine the CL/P isolated or companied with other animalities such as intellectual disability. We preformed comprehensive genetic test support counselling for which detected screening. Results 105 unrelated fetuses were enrolled. After excluding aneuploidy cases, SNP array and clinical exome sequencing (CES) simultaneously. All followed-up. Fetuses divided...
The utilization of separate culture chambers serves a dual purpose: it not only facilitates the creation hypoxic environment but also contributes to establishment consistently stable local environment.This, in turn, mitigates environmental stress factors.The primary objective this experiment was assess developmental potential sheep embryos before their implantation.This assessment conducted within confines 304 stainless steel chambers, offering viable alternative for maintaining vitro embryo...
Background: Junctional adhesion molecule-C (JAM-C) is an important regulator of many physiological processes, ranging from the maintenance tight junction integrity epithelia to regulation cell migration, homing and proliferation. Preeclampsia (PE) a trophoblast-related syndrome with abnormal implantation insufficient trophoblast invasion spiral arteries. What’s role JAM-C in trophoblasts differentiation migration normal pregnancy PE pathogenesis?Methods: The expression location placental...