A5034860785- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Renin-Angiotensin System Studies
- HIV Research and Treatment
- Muscle and Compartmental Disorders
- Electrolyte and hormonal disorders
- Renal and related cancers
- Nitric Oxide and Endothelin Effects
- HIV-related health complications and treatments
- Chronic Lymphocytic Leukemia Research
- HIV/AIDS drug development and treatment
- Neuropeptides and Animal Physiology
- Acute Kidney Injury Research
- Genetic and Kidney Cyst Diseases
- Dialysis and Renal Disease Management
- Ion Transport and Channel Regulation
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Heme Oxygenase-1 and Carbon Monoxide
- Hormonal Regulation and Hypertension
- Neurological and metabolic disorders
- Reproductive System and Pregnancy
- Neuroinflammation and Neurodegeneration Mechanisms
- Pharmacological Effects and Toxicity Studies
- Urinary Bladder and Prostate Research
- Biomedical Research and Pathophysiology
Feinstein Institute for Medical Research
2015-2025
Northwell Health
2009-2023
Hofstra University
2013-2023
Donald & Barbara Zucker School of Medicine at Hofstra/Northwell
2018-2023
Southwest Medical University
2022
Zhejiang University
2022
Long Island Jewish Medical Center
2004-2014
University of Bristol
2012-2014
Albert Einstein College of Medicine
1996-2013
New York Medical College
2011
The rate of acute kidney injury (AKI) associated with patients hospitalized Covid-19, and outcomes are not well understood. This study describes the presentation, risk factors AKI in Covid-19. We reviewed health records for all Covid-19 between March 1, April 5, 2020, at 13 academic community hospitals metropolitan New York. Patients younger than 18 years age, end stage disease or a transplant were excluded. was defined according to KDIGO criteria. Of 5,449 admitted developed 1,993 (36.6%)....
Outcomes of patients hospitalized with coronavirus disease 2019 (COVID-19) and acute kidney injury (AKI) are not well understood. The goal this study was to investigate the survival outcomes these patients.Retrospective cohort study.Patients (aged≥18 years) COVID-19 at 13 hospitals in metropolitan New York between March 1, 2020, April 27, followed up until hospital discharge.AKI.Primary outcome: in-hospital death.requiring dialysis discharge, recovery function.Univariable multivariable...
Antiretroviral therapy (ART) has decreased HIV-1 associated morbidity. However, despite ART, immune cells remain latently infected leading to chronic inflammation and comorbidities. New strategies are needed target viral proteins inflammation. We found activation of Notch3 in renal the mouse model (HIV-Tg26) patients with HIV nephropathy. hypothesized that targeting constitutes an effective for HIV-related kidney diseases (HIV-CKD). generated HIV-Tg26 mice knocked out (Tg-N3KO). Compared at...
Summary Seventeen patients with acute renal failure of diverse aetiology showed myoglobinuria and elevated levels serum creatine phosphokinase (mean 119·2 Sigma u./ml) adolase 88·5 Sibley-Lehninger (SL)u./ml), indicating the presence diffuse muscle cell injury. The primary conditions which led to rhabdomyolysis were burns, eclampsia, prolonged labour, crush injury, epileptiform convulsions, status asthmaticus, viral myositis intoxication chemicals including copper sulphate, mercuric chloride...
Abstract Laboratory data indicate that morphine decreases the number of peritoneal and alveolar macrophages (Mφ) compromises their phagocytic capability for immune complexes bacteria. We hypothesize of, as well Mφ by programming death. studied effect on apoptosis in vivo vitro. Peritoneal harvested from morphine-treated rats showed DNA fragmentation. Morphine enhanced murine (J 774.16) a dose-dependent manner. Human monocytes treated with classic ladder pattern gel electrophoretic...
Development of higher rates nondiabetic glomerulosclerosis (GS) in African Americans has been attributed to two coding sequence variants (G1 and G2) the APOL1 gene. To date, cellular function role (Vs) GS are still unknown. In this study, we examined effects overexpressing wild-type (G0) kidney disease risk human podocytes using a lentivirus expression system. Interestingly, G0 inflicted podocyte injury only at concentration; however, G1 G2 promoted moderate lower concentrations. APOL1Vs...
FSGS is characterized by segmental scarring of the glomerulus and a leading cause kidney failure. Identification genes causing has improved our understanding disease mechanisms points to defects in glomerular epithelial cell, podocyte, as major factor pathogenesis. Using combination genome-wide linkage studies whole-exome sequencing kindred with familial FSGS, we identified missense mutation R431C anillin (ANLN), an F-actin binding cell cycle gene, FSGS. We screened 250 additional families...
ANG II has been shown to modulate kidney cell growth and contribute the pathobiology of glomerulosclerosis. Glomerular visceral epithelial (GEC) injury or loss is considered play a pivotal role in initiation progression In present study, we investigated effect on GEC apoptosis. Rat GECs were incubated with increasing doses for variable time periods. Apoptosis was evaluated by nucleus staining DNA fragmentation assay. induced apoptosis dose- time-dependent manner. The proapoptotic attenuated...
ANG II has been demonstrated to play a role in the progression of tubulointerstial injury. We studied direct effect on apoptosis cultured rat renal proximal tubular epithelial cells (RPTECs). promoted RPTEC dose- and time-dependent manner. This was attenuated by anti-transforming growth factor (TGF)-β antibody. Moreover, TGF-β triggered dose-dependent also enhanced expression Fas ligand (FasL); furthermore, anti-FasL antibody II-induced apoptosis. In addition, increased Bax, cell death...
<i>Background/Aim:</i> In in vitro studies, angiotensin (Ang) II has been demonstrated to promote podocyte apoptosis. The present study evaluates the effects of Ang infusion rats on nephrin expression and apoptosis molecular mechanisms involved II-induced proteinuria mesangial expansion. <i>Methods:</i> Sprague-Dawley were randomly assigned receive either normal saline or (400 ng·kg<sup>–1</sup>·min<sup>–1</sup>) by means a mini-osmotic pump...
Podocytes are an integral and important constituent of the glomerular filtration barrier (GFB) exposed to a higher concentrations ANG II in diseased states; consequently, podocytes may accumulate oxidized proteins damaged mitochondria. In present study, we evaluated effect on podocyte autophagic process, which is likely be triggered order degrade unwanted organelles. To quantitate occurrence autophagy, electron microscopic studies were carried out control II-treated conditionally...
Abstract Occurrence of macrophage apoptosis has been implicated for the altered immune function found in an opiate milieu. In present study, we evaluated role oxidative stress morphine-induced apoptosis. Morphine promoted macrophages. This effect morphine was associated with production superoxide and nitric oxide (NO). Antioxidants provided protection against injury. addition, diphenyleneiodonium chloride, inhibitor reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase...
Summary An 18-year-old girl developed acute renal failure 24 hr after ingestion of potassium dichromate. Laboratory data revealed associated intravascular haemolysis. Renal histology showed features suggestive tubular necrosis. She went into diuretic phase 11 days oliguria and subsequently regained normal function. Both direct toxic damage by dichromate haemolysis may have contributed to the development necrosis failure.