A5088284368- Cell death mechanisms and regulation
- PARP inhibition in cancer therapy
- interferon and immune responses
- Cancer therapeutics and mechanisms
- Receptor Mechanisms and Signaling
- Histone Deacetylase Inhibitors Research
- Cancer-related Molecular Pathways
- Cultural Heritage Management and Preservation
- RNA Research and Splicing
- Immune Cell Function and Interaction
- CRISPR and Genetic Engineering
- Bioactive Compounds and Antitumor Agents
- Chemokine receptors and signaling
- Advanced Breast Cancer Therapies
- Lung Cancer Treatments and Mutations
- Immune Response and Inflammation
- Protein Degradation and Inhibitors
- Chronic Kidney Disease and Diabetes
- Cancer, Stress, Anesthesia, and Immune Response
- HIV Research and Treatment
- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- NF-κB Signaling Pathways
- RNA and protein synthesis mechanisms
- Phagocytosis and Immune Regulation
Brown University
2019-2021
Lifespan
2020-2021
Thomas Jefferson University
2021
Sidney Kimmel Cancer Center
2021
Indian Institute of Technology Bombay
2015
Feinstein Institute for Medical Research
2013-2014
Development of higher rates nondiabetic glomerulosclerosis (GS) in African Americans has been attributed to two coding sequence variants (G1 and G2) the APOL1 gene. To date, cellular function role (Vs) GS are still unknown. In this study, we examined effects overexpressing wild-type (G0) kidney disease risk human podocytes using a lentivirus expression system. Interestingly, G0 inflicted podocyte injury only at concentration; however, G1 G2 promoted moderate lower concentrations. APOL1Vs...
// Marie D. Ralff 1 , 2 Aakash Jhaveri 3 4 5 Jocelyn E. Ray 6 Lanlan Zhou 10 Avital Lev Kerry S. Campbell 7 David T. Dicker Eric A. Ross 8 and Wafik El-Deiry 9 MD/PhD Program, The Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA Laboratory Translational Oncology Experimental Cancer Therapeutics, Department Medical Molecular Therapeutics Fox Chase Center, Master Science in Biotechnology Warren Alpert School, Brown Providence, RI, Joint Program Biology, University the...
It is well known that patients with HIV are prone to diabetes mellitus because of the side effects HARRT. However, whether high glucose affects infection T cells not clear. Recent studies have shown upregulation GLUT-1 renders susceptible infection. We hypothesized hyperglycemia has potential increase by enhancing its entry into immune cells. The effect on (Jurkat and PBMCs) mechanisms involved were investigated. High significantly enhanced entry, which was associated increased T-cell...
The five-year survival rate for pancreatic ductal adenocarcinoma (PDAC) has remained a dismal 9% approximately 40 years with an urgent need novel therapeutic interventions. ONC201 is the founding member of imipridone class, comprised orally bioavailable small molecules that have shown efficacy in multiple tumor types both animal models and Phase I/II clinical trials. potent inducer necrosis factor related apoptosis inducing ligand (TRAIL) pathway. TRAIL innate immune mechanism which induces...
// Lindsey Carlsen 1 , 2 3 4 Christoph Schorl 5 6 8 Kelsey Huntington Liz Hernandez-Borrero Aakash Jhaveri Shengliang Zhang Lanlan Zhou and Wafik S. El-Deiry 7 Laboratory of Translational Oncology Experimental Cancer Therapeutics, The Warren Alpert Medical School, Brown University, Providence, RI 02903, USA Joint Program in Biology, University the Lifespan Health System, Department Pathology Medicine, Pathobiology Graduate Program, Molecular Cell Biology Biochemistry, Genomics Core Facility,...
ONC201 demonstrated promising activity in patients with advanced endometrial cancer a Phase I clinical trial. activates the integrated stress response (ISR) and upregulates TRAIL its receptor DR5. We hypothesized upregulation of DR5 could sensitize tumors to combination would lead enhanced cell death models. Five lines AN3CA, HEC1A, Ishikawa, RL952, KLE as well murine xenograft model were treated alone or TRAIL. decreased viability all five at clinically achievable low micro-molar...
Abstract The 7% five-year survival rate for pancreatic cancer patients has remained unchanged decades; the need novel therapeutic interventions is imminent. ONC201 founding member of impridone class, a class orally bioavailable small molecules which show efficacy in multiple tumor types. and ONC212, fluorinated imipridone, have been shown to be potent inducers necrosis factor related apoptosis inducing ligand (TRAIL) pathway. Both compounds are currently clinical trials. In context cancer,...
Abstract Pancreatic cancer is almost invariably fatal, often diagnosed in advanced stage and carrying a five-year survival rate of less than 5%. Cell-intrinsic oncogenic signaling supportive microenvironment renders neoplastic cells resistant to standard chemotherapy or immunotherapy, raising the urgent need for novel agents. ONC212, fluorinated imipridone, cytotoxic at nM doses against variety preclinical models. ONC212 engages seven-passage transmembrane receptor GPR132, which considered...
Abstract Pancreatic ductal adenocarcinoma (PDAC) is an aggressive and lethal cancer with a 4.2% 5-year survival rate. There urgent need for innovative treatments patients suffering from PDAC. Patients PDAC often have immunosuppressed tumors that are apoptosis-resistant limited immune cell infiltration and/or activation. Tumor necrosis factor-Related Apoptosis-Inducing Ligand (TRAIL) selectively induces apoptosis during innate immunity, while ONC212 potent fluorinated second-generation...