A5068051991- Cancer Immunotherapy and Biomarkers
- Cancer-related Molecular Pathways
- Immune Cell Function and Interaction
- Cancer Research and Treatments
- Cancer Cells and Metastasis
- Cancer Genomics and Diagnostics
- Prostate Cancer Treatment and Research
- Cancer, Hypoxia, and Metabolism
- Preterm Birth and Chorioamnionitis
- Colorectal Cancer Treatments and Studies
- Genetic factors in colorectal cancer
- Immunotherapy and Immune Responses
- COVID-19 Clinical Research Studies
- Ferroptosis and cancer prognosis
- Radiomics and Machine Learning in Medical Imaging
- Nanoplatforms for cancer theranostics
- Cancer, Stress, Anesthesia, and Immune Response
- Photodynamic Therapy Research Studies
- Phagocytosis and Immune Regulation
- Immune Response and Inflammation
- Cell Adhesion Molecules Research
- Ultrasound Imaging and Elastography
- Glioma Diagnosis and Treatment
- Autophagy in Disease and Therapy
- SARS-CoV-2 and COVID-19 Research
Brown University
2020-2024
Lifespan
2020-2024
Providence College
2020-2022
John Brown University
2022
Roswell Park Comprehensive Cancer Center
2019
University of Wisconsin–Madison
2011-2014
Cyclotron (Netherlands)
1985
Vrije Universiteit Brussel
1985
As COVID-19 continues to pose major risk for vulnerable populations, including the elderly, immunocompromised, patients with cancer, and those contraindications vaccination, novel treatment strategies are urgently needed. SARS-CoV-2 infects target cells via RGD-binding integrins, either independently or as a co-receptor surface receptor angiotensin-converting enzyme 2 (ACE2). We used pan-integrin inhibitor GLPG-0187 demonstrate blockade of pseudovirus infection cells. Omicron infected normal...
COVID-19 affects vulnerable populations including elderly individuals and patients with cancer. Natural Killer (NK) cells innate-immune TRAIL suppress transformed virally-infected cells. ACE2, TMPRSS2 protease promote SARS-CoV-2 infectivity, while inflammatory cytokines IL-6, or G-CSF worsen severity. We show MEK inhibitors (MEKi) VS-6766, trametinib selumetinib reduce ACE2 expression in human In some cells, remdesivir increases ACE2-promoter luciferase-reporter expression, mRNA protein, is...
TP53 is a tumor suppressor gene that encodes sequence-specific DNA-binding transcription factor activated by stressful stimuli and upregulates target genes involved in growth suppression, cell death, DNA repair, metabolism, among others. P53 the most frequently mutated tumors with mutations not only leading to loss-of-function (LOF), but also gain-of-function (GOF) which promotes progression, metastasis. The tumor-specific status of mutant p53 protein has suggested it promising for cancer...
// Lindsey Carlsen 1 , 2 3 4 Christoph Schorl 5 6 8 Kelsey Huntington Liz Hernandez-Borrero Aakash Jhaveri Shengliang Zhang Lanlan Zhou and Wafik S. El-Deiry 7 Laboratory of Translational Oncology Experimental Cancer Therapeutics, The Warren Alpert Medical School, Brown University, Providence, RI 02903, USA Joint Program in Biology, University the Lifespan Health System, Department Pathology Medicine, Pathobiology Graduate Program, Molecular Cell Biology Biochemistry, Genomics Core Facility,...
As COVID-19 continues to pose major risk for vulnerable populations including the elderly, immunocompromised, patients with cancer, and those contraindications vaccination, novel treatment strategies are urgently needed. SARS-CoV-2 infects target cells via RGD-binding integrins either independently or as a co-receptor surface receptor angiotensin-converting enzyme 2 (ACE2). We used pan-integrin inhibitor GLPG-0187 demonstrate blockade of pseudovirus infection cells. Omicron infected normal...
COVID-19 affects vulnerable populations including elderly individuals and patients with cancer. Natural Killer (NK) cells innate-immune TRAIL suppress transformed virally-infected cells. ACE2, TMPRSS2 protease promote SARS-CoV-2 infectivity, while inflammatory cytokines IL-6, or G-CSF worsen severity. We show MEK inhibitors (MEKi) VS-6766, trametinib selumetinib reduce ACE2 expression in human In some cells, remdesivir increases ACE2-promoter luciferase-reporter expression, mRNA protein, is...
Abstract Metastatic colorectal cancer (mCRC) is a deadly disease with five-year survival rate of 14%. Most patients receive 5-FU (F) and folinic acid (FOL) combined oxaliplatin (OX), irinotecan (IRI), or both (OXIRI). Immune checkpoint inhibitors (ICIs) are effective against microsatellite instable (MSI) tumors, but 95% mCRC tumors stable (MSS) ICI-resistant. Though the primary targets 5-FU, irinotecan, well-understood, their effects on tumor microenvironment (TME) remain incompletely...
Abstract Our previous work studying the effects of integrin αvβ6 knockdown in cancer cells demonstrated as a method T cell suppression co-culture model. ITGB6, gene encoding β6 subunit αvβ6, is potent prognostic marker across multiple types. As major activator latent TGFβ, and consequently, has considerable therapeutic implications due to immunosuppressive effect that activated TGFβ on tumor microenvironment. A Human Protein Atlas search ITGB6 expression surveyed upregulation Cancer was then...
Colorectal cancer (CRC) and breast (BC) are deadly diseases that rank as the second fourth leading causes of cancer-related deaths, respectively. We have previously shown miR-6883 targets CDK4/6 palbociclib-mediated inhibition destabilizes HIF1α. hypothesize downregulates HIF1α in CRC BC cells. was transfected into cells under normoxia or hypoxia western blot analysis revealed cells, pointing to a promising therapeutic target hypoxic tumors HIF1α-deregulated Future studies will further...
// Sofia Leaf 1 , 2 3 4 * Lindsey Carlsen 5 and Wafik S. El-Deiry 6 Laboratory of Translational Oncology Experimental Cancer Therapeutics, The Warren Alpert Medical School, Brown University, Providence, RI 02903, USA Joint Program in Biology, University the Lifespan Health System, Department Pathology Medicine, Center at Pathobiology Graduate Program, Hematology-Oncology Division, Rhode Island Hospital These authors contributed equally to this work Correspondence to: El-Deiry, email:...
Intraoperative photodynamic therapy (IO-PDT) is typically administered by a handheld light source. This can result in uncontrolled distribution of irradiance that impacts tissue and tumor response to therapy. The objective this work was characterize novel optical surface applicator (OSA) designed administer controlled IO-PDT.An OSA constructed from flexible silicone mesh with multiple cylindrically diffusing fibers (CDF) placed into channels the silicone. Light distribution, at 665 nm,...
Abstract Background: Inhibition of the androgen pathway remains central to treatment prostate cancer, but most patients progress a lethal state metastatic castration-resistant cancer (mCRPC). Immune checkpoint inhibitors have limited role in mCRPC, although receptor (AR) blockade increases CD8+ T cell function and can modulate antitumor immune response. We investigated effect AR (ARi) enzalutamide (Enza) darolutamide (Daro) on NK function.Materials Methods: evaluated viability investigate...