A5008196559- MicroRNA in disease regulation
- RNA modifications and cancer
- RNA and protein synthesis mechanisms
- RNA Interference and Gene Delivery
- Genetics, Bioinformatics, and Biomedical Research
- Histone Deacetylase Inhibitors Research
- Cancer Genomics and Diagnostics
- Cancer, Hypoxia, and Metabolism
- Advanced biosensing and bioanalysis techniques
- Glioma Diagnosis and Treatment
- RNA Research and Splicing
- Epigenetics and DNA Methylation
- Extracellular vesicles in disease
- Circular RNAs in diseases
- Biosimilars and Bioanalytical Methods
- Cancer-related Molecular Pathways
- Cell death mechanisms and regulation
- Cancer Research and Treatments
- Pancreatic function and diabetes
- Cancer, Lipids, and Metabolism
- Bioinformatics and Genomic Networks
- Cell Image Analysis Techniques
- Prostate Cancer Treatment and Research
- Ubiquitin and proteasome pathways
- PI3K/AKT/mTOR signaling in cancer
Brown University
2019-2025
Lifespan
2019-2025
John Brown University
2025
University Health System
2025
Translational Research in Oncology
2024
Pfizer (United States)
2010-2020
Providence College
2020
Temple University Health System
2019
Translational Research Institute for Metabolism and Diabetes
2014-2018
Massachusetts Institute of Technology
2014-2018
Abstract A rift that has opened up between basic research (bench) and clinical patients (bed) who need their new treatments, diagnostics prevention, this is widening getting deeper. The crisis involving the “translation” of scientific findings in a laboratory setting into human applications potential treatments or biomarkers for disease widely recognized both academia industry. Despite attempts have been made academic industry settings to mitigate problem, high attrition rates drug...
The discovery of the link between microRNAs (miRNAs) and a myriad human diseases, particularly various cancer types, has generated significant interest in exploring their potential as novel class drugs. This led to substantial investments interdisciplinary research fields such biology, chemistry, medical science for development miRNA-based therapies. Furthermore, recent global success SARS-CoV-2 mRNA vaccines against COVID-19 pandemic further revitalized RNA-based immunotherapies, including...
Abstract The clinical presentation of diabetes sometimes overlaps, contributing to ambiguity in the diagnosis. Thus, circulating pancreatic islet-enriched microRNAs (miRNAs) might be useful biomarkers β-cell injury/dysfunction that would allow more accurate subtyping diabetes. We measured plasma levels selected miRNAs subjects with prediabetes (n = 12), type 2 (T2D, n 31), latent autoimmune adults (LADA, 6) and 1 (T1D, 16) compared them healthy control 27). study was conducted at...
Today obesity and type 2 diabetes (T2D) have both reached epidemic proportions. However, our current understanding of the primary mechanisms leading to these diseases is still limited due complex multifactorial nature underlying phenomena. We hypothesize that levels specific cytokines miRNAs vary across spectrum unique signatures associated with them may serve as early biomarkers disease provide insights into respective pathogenetic mechanisms. In this study, we measured circulating...
ONC201/TIC10 activates TRAIL signaling through ATF4 and the integrated stress response (ISR). ONC201 demonstrated tumor regressions disease stability in patients with histone H3K27M-mutated midline-glioma. H3K27M-mutation prevents H3K27-methylation on mutated allele. EZH2 inhibitors (EZH2i) reduce H3K27 methylation have anti-tumor effects. We hypothesized sensitivity apoptosis may increase by reducing EZH2i or HDACi as mimics of H3K27M-mutation. EPZ-6438 (tazemetostat) PF-06821497 vorinostat...
Short-term intensive insulin therapy (IIT) early in the course of type 2 diabetes acutely improves beta-cell function with long-lasting effects on glycemic control. However, conventional measures cannot determine which patients are better suited for IIT, and little is known about molecular mechanisms determining response. Therefore, this study aimed to develop a model that could accurately predict response IIT provide insight into driving such humans. Twenty-four were assessed at baseline...
We explored the relationships among microRNAs (miRNAs) and SFRP4, as they relate to adipose tissue functions including lipolysis, glucose glycerol turnover, insulin sensitivity. Abdominal (AbdAT) levels of thirteen (miRNAs), VEGF in lean nondiabetic subjects (n = 7), with obesity 5), type 2 diabetes (T2DM) 5) were measured by qPCR. Insulin sensitivity was euglycemic-hyperinsulinemic clamp. Osmium fixation Coulter counting used for adipocyte sizing. Data analyzed using generalized linear...
Hepatitis C virus (HCV) is a leading cause of liver cirrhosis and hepatocellular carcinoma worldwide. Currently available treatment options are limited efficacy, there an urgent need for development alternative therapies. RNA interference (RNAi) natural mechanism by which small interfering (siRNA) or short hairpin (shRNA) can mediate degradation target molecule in sequence-specific manner. In this study, we screened vitro-transcribed 25-bp shRNAs targeting the internal ribosome entry site...
Radiotherapy can be limited by pneumonitis which is impacted innate immunity, including pathways regulated TRAIL death receptor DR5. We investigated whether DR5 agonists could rescue mice from toxic effects of radiation and found two different agonists, parenteral PEGylated trimeric-TRAIL (TLY012) oral TRAIL-Inducing Compound (TIC10/ONC201) reduce pneumonitis, alveolar-wall thickness, oxygen desaturation. Lung protection extended to late less fibrosis at 22-weeks in TLY012-rescued survivors...