A5026954752- Heavy Metal Exposure and Toxicity
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Trace Elements in Health
- Chronic Kidney Disease and Diabetes
- Renal Diseases and Glomerulopathies
- Drug Transport and Resistance Mechanisms
- Multiple Myeloma Research and Treatments
- Nephrotoxicity and Medicinal Plants
- Dialysis and Renal Disease Management
- Diabetes Treatment and Management
- Blood Pressure and Hypertension Studies
- Neuropeptides and Animal Physiology
- Drug-Induced Hepatotoxicity and Protection
- Renin-Angiotensin System Studies
- Heavy metals in environment
- Diabetes Management and Research
- Ion Transport and Channel Regulation
- Electrolyte and hormonal disorders
- Sodium Intake and Health
- Acute Kidney Injury Research
- Renal function and acid-base balance
- Hormonal Regulation and Hypertension
- Pharmacological Effects and Toxicity Studies
- Peptidase Inhibition and Analysis
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
Tulane University
2014-2024
Southeast Louisiana Veterans Health Care System
2011-2022
Tulane Medical Center
2001-2018
Rutgers New Jersey Medical School
1978-2015
Veterans Biomedical Research Institute
1981-2015
Rutgers, The State University of New Jersey
1978-2015
University Hospital and Clinics
2006-2014
University Medical Center New Orleans
2001-2012
Hypertension Institute
2010-2011
United States Department of Veterans Affairs
2003-2010
The optimal intensity of renal-replacement therapy in critically ill patients with acute kidney injury is controversial.We randomly assigned and failure at least one nonrenal organ or sepsis to receive intensive less therapy. primary end point was death from any cause by day 60. In both study groups, hemodynamically stable underwent intermittent hemodialysis, unstable continuous venovenous hemodiafiltration sustained low-efficiency dialysis. Patients receiving the treatment strategy...
Background: The metabolic syndrome is a common risk factor for cardiovascular disease. Objective: To examine the association between and chronic kidney disease microalbuminuria. Design: Cross-sectional study. Setting: Third National Health Nutrition Examination Survey. Patients: Participants 20 years of age or older were studied in (n = 6217) microalbuminuria 6125) analyses. Measurements: was defined as presence 3 more following factors: elevated blood pressure, low high-density lipoprotein...
Background— Blood lead levels above 0.48 μmol/L (10 μg/dL) in adults have been associated with increased risk of cardiovascular, cancer, and all-cause mortality. The objective the present study was to determine association between blood below mortality general US population. Methods Results— were measured a nationally representative sample 13 946 adult participants Third National Health Nutrition Examination Survey recruited 1988 1994 followed up for 12 years cause-specific geometric mean...
ABSTRACT. This study examined the relationship of fasting serum glucose, insulin, C-peptide, glycosylated hemoglobin A (HbA1c), and Homeostasis Model Assessment (HOMA)-insulin resistance to risk chronic kidney disease (CKD) among 6453 persons without diabetes (fasting glucose <126 mg/dl not taking medication) who participated in Third National Health Nutrition Examination Survey were aged 20 yr or older. CKD was defined as an estimated GFR <60 ml/min per 1.73 m<sup>2</sup>. The...
Background: This study was performed to determine whether, in high-risk hypertensive patients with a reduced glomerular filtration rate (GFR), treatment calcium channel blocker or an angiotensin-converting enzyme inhibitor lowers the incidence of renal disease outcomes compared diuretic. Methods:We conducted post hoc analyses Antihypertensive and Lipid-Lowering Treatment Prevent Heart Attack Trial (ALLHAT).Hypertensive participants 55 years older at least 1 other coronary heart risk factor...
Background: Declines in blood lead levels between 1976 and 1991 among US adults have been previously reported.More recent trends the association of lower with chronic disease not reported.Methods: Data from 2 nationally representative crosssectional surveys, Third National Health Nutrition Examination Survey conducted 1988-1994 (n=16 609) 1999-2002 (n=9961) were analyzed. Results:The geometric mean level declined 41% 2.76 µg/dL (0.13 µmol/L) to 1.64 (0.08 1999-2002.The percentage 10 (0.48 or...
Hypertension of unknown cause is generally termed "essential." Because hypertension has long been considered a possible complication lead poisoning and the EDTA lead-mobilization test proved to be sensitive indicator excessive body stores lead, we used this evaluate cumulative past absorption in 48 men diagnosed as having essential hypertension. Patients who had with reduced renal function (i.e., serum creatinine level greater than 1.5 mg per deciliter [133 mumols liter]) significantly...
Background. The metabolic syndrome is a common risk factor for cardiovascular and chronic kidney disease (CKD) in Western populations. We examined the relationship between of CKD Chinese adults. Methods. A cross-sectional survey was conducted nationally representative sample 15 160 adults aged 35–74 years. defined as presence three or more following factors: elevated blood pressure, low high density lipoprotein (HDL)-cholesterol, triglycerides, plasma glucose abdominal obesity. an estimated...
UNTIL recently, renal disease was considered a major cause of death among patients with gout.1 Modern long-term follow-up studies function, however, have indicated that hyperuricemia and gout rarely result in kidney damage unless other supervenes.2 3 4 These conflicting views the occurrence might be reconciled if single agent could identified as both some patients. Lead is likely candidate for such an agent, since this heavy metal has long been recognized causative factor nephropathy.5 To test .
We studied the association of inflammatory biomarkers including C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), and interleukin-6 (IL-6) with chronic kidney disease (CKD).We conducted a case-control study among 201 CKD patients community-based controls in greater New Orleans area. was defined as estimated-glomerular filtration rate (eGFR) <60 mL/min/1.73 m(2) or albuminuria ≥30 mg/24-h. Serum CRP, TNF-α, IL-6 were measured using standard methods. Multivariable regression...
Although myeloma light chains are known to undergo receptor-mediated endocytosis in the kidney, molecular identity of receptor has not been characterized. We examined interaction between cubilin (gp280) and four species isolated from urine patients with multiple myeloma. Four lines evidence identify cubilin, a giant glycoprotein receptor, which is restricted distribution endocytic scavenger pathways potent effects on endosomal trafficking, as potentially physiologically relevant binding site...
Chronic lead exposure has been associated with elevated blood pressure in epidemiological studies. It is not known whether the previously observed relation between and hypertension persists after significant reductions have made environmental contamination. We examined levels a representative sample of 14 952 whites blacks aged 18 years or older who participated Third National Health Nutrition Examination Survey. Blood was measured by atomic absorption spectrophotometry standard...
The proximal tubules make up a significant portion of the kidneys; tubule epithelial cells are most populous cell type in kidney, and carry out diverse regulatory endocrine functions where numerous transporters located. Under normal circumstances, more than two thirds filtered salt water, all bicarbonate is reabsorbed tubule. A number inherited acquired acid-base disorders linked to impaired cells. Equally important intrinsic immune characteristics that give them ability also function as...
Anemia is common among patients with chronic kidney disease (CKD) but its health consequences are poorly defined. The aim of this study was to determine the relationship between anemia and cognitive decline in older adults CKD. We studied a subgroup 762 age ≥55 years CKD participating Chronic Renal Insufficiency Cohort (CRIC) study. defined according World Health Organization criteria (hemoglobin <13 g/dL for men <12 women). Cognitive function assessed annually battery six tests. used...
Serum vitamin C has been inversely associated with blood pressure in several epidemiologic studies, but little is known about effect of other antioxidant vitamins. We examined the relation between serum vitamins A, C, and E, α-carotene, β-carotene levels among 15 317 men women ≥20 years age who participated Third National Health Nutrition Examination Survey. Blood was characterized as average 6 measurements obtained over 2 visits by trained observers hypertension defined ≥140/90 mm Hg and/or...
The effect of intrarenal renin–angiotensin system (RAS) activity on risk chronic kidney disease (CKD) has not been well studied in human subjects. We investigated the association between urinary angiotensinogen, a reliable biomarker RAS activity, and CKD 201 patients controls. was defined as estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m2 or presence albuminuria ( ≥ 30 mg/24 h). Compared to controls, median angiotensinogen excretion (45.4 versus 7.4 μg/24 h, P 0.0001)...
We previously described angiotensin II type 1 receptor-activating antibodies (AT1R-Abs) in renal transplant recipients with vascular rejection and malignant hypertension. In this study, we tested the hypothesis that AT1R-Abs can cause artery contraction by AT1R activation ischemia representing a key permissive factor therefore contribute to pathologic condition.Isolated mesenteric arteries from Lewis rats were incubated purified patients human leukocyte antigen antibody-negative rejection....