A5101524373- Platelet Disorders and Treatments
- Autoimmune Bullous Skin Diseases
- Chronic Lymphocytic Leukemia Research
- Renal Diseases and Glomerulopathies
- Diabetes Management and Research
- Neonatal Respiratory Health Research
- Acute Kidney Injury Research
- Vitamin D Research Studies
- Diabetes and associated disorders
- Dialysis and Renal Disease Management
- Systemic Sclerosis and Related Diseases
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Liver Disease Diagnosis and Treatment
- Infant Development and Preterm Care
- Bone health and osteoporosis research
- Thyroid Cancer Diagnosis and Treatment
- Medical Imaging and Pathology Studies
- Organ Donation and Transplantation
- Hepatitis C virus research
- Systemic Lupus Erythematosus Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Sepsis Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Obesity and Health Practices
- Body Image and Dysmorphia Studies
Principia Biopharma (United States)
2021-2024
Sanofi (United States)
2021-2024
Max Super Speciality Hospital
2017-2024
Children's Hospital of Los Angeles
2024
Kaiser Permanente South San Francisco Medical Center
2022
Banaras Hindu University
2012-2015
Institute of Medical Sciences
2011-2015
Homerton University Hospital NHS Foundation Trust
2013
Amgen (United States)
2012
Homerton University Hospital
2011
The optimal intensity of renal-replacement therapy in critically ill patients with acute kidney injury is controversial.We randomly assigned and failure at least one nonrenal organ or sepsis to receive intensive less therapy. primary end point was death from any cause by day 60. In both study groups, hemodynamically stable underwent intermittent hemodialysis, unstable continuous venovenous hemodiafiltration sustained low-efficiency dialysis. Patients receiving the treatment strategy...
Glucose tolerance decreases with age. For determining the cause of this decrease, 67 elderly and 21 young (70.1 ± 0.7 vs. 23.7 0.8 years) participants ingested a mixed meal received an intravenous injection glucose. Fasting glucose glycemic response above basal were higher in than after either ingestion (P < 0.001) or 0.01). Insulin action (Si), measured test models, was highly correlated (r = 0.72; P lower ≤ 0.002) participants. However, when adjusted for differences percentage body...
Rilzabrutinib, an oral, reversible covalent inhibitor of Bruton's tyrosine kinase, may increase platelet counts in patients with immune thrombocytopenia by means dual mechanisms action: decreased macrophage (Fcγ receptor)–mediated destruction and reduced production pathogenic autoantibodies.
Sclerostin, a protein secreted by osteocytes, inhibits bone formation. Individuals with genetic mutations that decrease the availability of sclerostin have very high mass.The aim this study was to examine hypothesis elevated serum levels are associated increased risk hip fracture in older women.This case-cohort prospective, community-based cohort 9704 women aged 65 yr or older. Sclerostin were measured collected 1989-1990 228 incident fractures and 227 randomly selected sample; average...
Significance Fibroblast growth factor 21 (FGF21) controls metabolic organ homeostasis and eating behavior via FGF receptor 1/Klothoβ (FGFR1/KLB) complexes. Here we show that a bispecific anti-FGFR1/KLB agonist antibody, BFKB8488A, mimics the actions of FGF21 in monkeys humans. BFKB8488A induced marked weight loss obese while elevating expression FGFR1 target genes adipose tissue. A clinical study overweight human participants demonstrated single dose caused transient body reduction,...
Bruton tyrosine kinase (BTK) inhibition targets B-cell and other non-T-cell immune cells implicated in the pathophysiology of pemphigus, an autoimmune disease driven by anti-desmoglein autoantibodies. Rilzabrutinib is a new reversible, covalent BTK inhibitor demonstrating preclinical efficacy as monotherapy canine pemphigus foliaceus.To evaluate safety oral rilzabrutinib patients with vulgaris multicentre, proof-of-concept, phase II trial.Patients Pemphigus Disease Area Index severity scores...
Diabetic foot ulcers (DFU) are one of the major complications in type II diabetes patients and can result amputation morbidity. Although multiple approaches used clinically to help wound closure, many still lack adequate treatment. Here we show that IL-20 subfamily cytokines upregulated during normal healing. While there is a redundant role for each individual cytokine this healing, mice deficient IL-22R, common receptor chain IL-20, IL-22, IL-24, display significant delay Furthermore, IL-22...
Trial design Pemphigus is a rare, but life-threatening autoimmune disease requiring long-term treatment that minimizes corticosteroid (CS) exposure while providing consistent control. The phase 2 pemphigus study of oral, reversible, covalent Bruton tyrosine kinase (BTK) inhibitor rilzabrutinib demonstrated rapid and sustained efficacy with well-tolerated safety. Methods Adults (18–80 y) were randomized 1:1 to 400 mg (n=65) or placebo (n=66) twice daily (with CS ≤0.5 mg/kg/d) for 37 weeks in...
There are limited studies describing various renal disorders and their prognostic impact in patients with cirrhosis of liver. The aim this work was to study the clinical spectrum liver impact.Patients diagnosis were included study. Cirrhosis diagnosed using standard criteria. cirrhotic prospectively analyzed for presence diseases during period from January 2008 April 2009.Four hundred four present 44% (n = 178) patients. acute kidney injury (AKI; 24.5%), chronic disease (CKD; 15.6%), on...
To evaluate the analgesic efficacy and safety of intramuscular drotaverine hydrochloride vs diclofenac sodium in treatment acute renal colic.We conducted a randomized, single-blind study comparing single doses (80 mg) (75 on 100 patients (50 each arm) presenting to emergency department (ED) with colic. Subjects inadequate pain relief at 30 minutes received rescue tramadol (100 mg). Pain intensity was recorded using visual analog scale (VAS), which is primary outcome measure this study,...
Abstract This open‐label, phase 1 study was conducted with healthy adult participants to evaluate the potential drug‐drug interaction between rilzabrutinib and quinidine (an inhibitor of P‐glycoprotein [P‐gp] CYP2D6) or rifampin inducer CYP3A P‐gp). Plasma concentrations were measured after a single oral dose 400 mg administered on day again, following wash‐out period, co‐administration rifampin. Specifically, given at 300 every 8 hours for 5 days from 7 11 (N = 16) while as 600 once daily...
A repeat kidney transplant is the preferred treatment for graft failure due to its enhanced survival benefits and improved quality of life, despite facing greater medical, immunological, surgical challenges compared first transplant. Immunosuppressive medications are indispensable organ recipients prevent rejection prolong viability transplanted organs. At present, triple-drug therapy comprising calcineurin inhibitors, corticosteroids, antiproliferative prevailing protocol immunosuppressive...
Non-diabetic renal diseases (NDRDs) form an important part of disease manifestations in patients with diabetes.
Kimura's disease is a rare chronic eosinophilic inflammatory disorder of unknown etiology. Majority cases have been reported from South East Asia, while sporadic occurrences worldwide, including the Indian subcontinent. Nephrotic syndrome may be presenting manifestation disease, and variety renal lesions are observed histologically in such patients. We herein describe case steroid-responsive mesangioproliferative glomerulonephritis related to kimura's disease.