A5088018293- Financial Markets and Investment Strategies
- Corporate Finance and Governance
- Housing Market and Economics
- Financial Reporting and Valuation Research
- Auditing, Earnings Management, Governance
- Neonatal Respiratory Health Research
- Financial Literacy, Pension, Retirement Analysis
- Photosynthetic Processes and Mechanisms
- Renal and related cancers
- Algal biology and biofuel production
- Market Dynamics and Volatility
- Private Equity and Venture Capital
- Light effects on plants
- Cystic Fibrosis Research Advances
- Monetary Policy and Economic Impact
- State Capitalism and Financial Governance
- Biosimilars and Bioanalytical Methods
- Banking stability, regulation, efficiency
- Energy Harvesting in Wireless Networks
- Platelet Disorders and Treatments
- Global Financial Crisis and Policies
- Statistical Methods in Clinical Trials
- Economic Policies and Impacts
- FOXO transcription factor regulation
- Global Health Care Issues
Colorado School of Mines
2018-2023
Boston Medical Center
2017-2022
Boston University
2016-2022
Principia Biopharma (United States)
2021
Sanofi (United States)
2021
Queen Mary University of London
2004-2017
Center for Neuroscience and Regenerative Medicine
2017
London School of Business and Management
2014-2016
City, University of London
2004-2016
Pfizer (United States)
2014-2015
It has been postulated that during human fetal development, all cells of the lung epithelium derive from embryonic, endodermal, NK2 homeobox 1-expressing (NKX2-1+) precursor cells. However, this hypothesis not formally tested owing to an inability purify or track these progenitors for detailed characterization. Here we have engineered and developmentally differentiated NKX2-1GFP reporter pluripotent stem (PSCs) in vitro generate isolate primordial express NKX2-1 but are initially devoid...
If arbitrage is costly and noise traders are active, asset prices may deviate from fundamental values for long periods of time. We use a sample 158 closed‐end funds to show that noise‐trader sentiment, as proxied by retail‐investor flows, leads fluctuations in the discount. Nevertheless, we reject hypothesis risk cause long‐run Instead find which more difficult have larger discounts, due to: (1) censoring discount bounds, (2) freedom managers increase charges when costly.
This is an empirical study of single‐period income smoothing which uses incentives‐based model to explain classificatory choices. An index constructed measure the effect these Weighted least squares regression results indicate that choices consistent with are more likely be observed in firms high earnings variability, dividend payout, substantial managerial holdings share options and diffuse ownership. The existence material scope for strengthens findings. as a whole statistically...
Bruton tyrosine kinase (BTK) inhibition targets B-cell and other non-T-cell immune cells implicated in the pathophysiology of pemphigus, an autoimmune disease driven by anti-desmoglein autoantibodies. Rilzabrutinib is a new reversible, covalent BTK inhibitor demonstrating preclinical efficacy as monotherapy canine pemphigus foliaceus.To evaluate safety oral rilzabrutinib patients with vulgaris multicentre, proof-of-concept, phase II trial.Patients Pemphigus Disease Area Index severity scores...
Significance Most forms of life on Earth cannot exist without photosynthesis. Our food and atmosphere depend it. To obtain high photosynthetic yields, light energy must be efficiently coupled to the fixation CO 2 into organic molecules. Suboptimal environmental conditions can severely impact conversion biomass lead reactive oxygen production, which in turn cause cellular damage loss productivity. Hence, plants, algae, bacteria have evolved a network alternative outlets sustain flow...
Abstract Cystic fibrosis is a monogenic lung disease caused by dysfunction of the cystic transmembrane conductance regulator anion channel, resulting in significant morbidity and mortality. The progress elucidating role CFTR using established animal cell-based models led to recent discovery effective modulators for most individuals with CF. However, subset CF do not respond these there an urgent need develop novel therapeutic strategies. In this study, we generate panel airway epithelial...
Abstract Option pricing theory provides a robust and theoretically sound framework for the measurement of credit risk. Assuming perfect market conditions, information relevant to firm's risk is reflected in its equity price, with no role accounting data. This hypothesis tested using UK data ratings as proxy It found that Merton's distance-to-default measure most significant variable However, it also variables are incrementally informative when added model contains only measure. The...
Abstract This study uses a large sample of UK‐listed closed‐end funds to examine whether governance has an impact on two indicators fund performance: the level fund‐management fees and discount at which trades. Fees are under control directors, we find that they inversely related returns, even after allowing for differences across investment sectors. are, average, higher if board, few directors from outside fund‐family, many within low ownership by management company. Discounts wider company...
Abstract Photosynthetic organisms frequently experience abiotic stress that restricts their growth and development. Under such circumstances, most absorbed solar energy cannot be used for CO2 fixation can cause the photoproduction of reactive oxygen species (ROS) damage photosynthetic reaction centers PSI PSII, resulting in a decline primary productivity. This work describes biological “switch” green alga Chlamydomonas reinhardtii reversibly electron transport (PET) at cytochrome b6f (Cyt...
Abstract: :Early detection of aortic dilatation in ankylosing spondylitis using echocardiography. D. Thomas, W. Hill, R. Geddes, M. Sheppard, J. Arnold, Fritzsche and P. Brooks, Aust. N.Z. Med., 1982, 12, pp. 10–13. Aortic root abnormalities including cusp thickening, subvalvular stenosis, mild are the most common cardiac complications patients with long standing (AS). Twenty-three definite idiopathic AS (New York Criteria 1966) twenty-two matched controls were studied M-mode Only one had...
Conventional companies are heterogeneous and it is difficult to identify whether governance affects their performance. Closed-end funds with clear objectives, allowing effects be revealed. We find that, for the 331 listed in London, returns negatively related expense ratios. In turn, ratios higher which have large boards, less outside directors low ownership by managers. The main conclusion that small boards more perform better. Ownership managers has a mixed impact: while leads better...
Abstract Share prices rise after companies announce repurchases, but there are differing views as to why this happens. Repurchases announced by closed‐end funds when their discounts widening (market‐to‐book is falling). The immediate post‐announcement effect a small jump in fund's share price, the main occurs over next four years during which time significant outperformance both of price and its investment portfolio. Liquidity shares does not change. Repurchases, if executed, reduce size...