A5058145741- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Medicinal Plants and Neuroprotection
- Vector-borne infectious diseases
- Heat shock proteins research
- Phytochemicals and Antioxidant Activities
- Circular RNAs in diseases
- RNA modifications and cancer
- Hedgehog Signaling Pathway Studies
- Neurogenesis and neuroplasticity mechanisms
- Pharmacological Effects of Natural Compounds
- Signaling Pathways in Disease
- Renal cell carcinoma treatment
- Cytokine Signaling Pathways and Interactions
- Osteoarthritis Treatment and Mechanisms
- Alzheimer's disease research and treatments
- Toxin Mechanisms and Immunotoxins
- Bioactive Compounds in Plants
- Molecular Biology Techniques and Applications
- Inflammatory mediators and NSAID effects
- Natural product bioactivities and synthesis
- Cholinesterase and Neurodegenerative Diseases
- Biochemical effects in animals
Jiangsu University
2020-2024
Zhejiang Provincial Hospital of TCM
2024
Huazhong Agricultural University
2014-2023
Chongqing Medical University
2021-2023
Second Affiliated Hospital of Chongqing Medical University
2021-2023
University of Chinese Academy of Sciences
2019-2023
Dalian Medical University
2021-2023
Nanjing Medical University
2010-2023
Affiliated Hospital of Qingdao University
2023
University of Hong Kong
2023
Robust object detection methods in traffic surveillance scenarios often encounters challenges due to large-scale deformations and illumination variations outdoor scenes. To enhance the tolerance of such against these variations, we design a cross-scale illumination-invariant model (CSIM) based on You Only Look Once (YOLO) architecture. A main cause false tasks is inconsistency between various feature scales. address this issue, introduce an adaptive fusion ensure consistency constructed...
Panicle architecture is a key determinant of rice grain yield and mainly determined at the 1-2 mm young panicle stage. Here, we investigated transcriptome panicles from 275 varieties identified thousands genes whose expression levels were associated with traits. Multimodel association studies suggested that many small-effect genetic loci determine spikelet per (SPP) by regulating We found alleles cis-expression quantitative trait SPP-associated underwent positive selection, strong preference...
Abstract Background Circular RNAs (circRNAs) play important roles in cancer progression and metastasis. However, the expression profiles biological of circRNAs non-small cell lung (NSCLC) remain unclear. Methods In this study, we identified a novel circRNA, hsa_circ_0006834 (termed circ6834), NSCLC by RNA-seq investigated role circ6834 vitro vivo. Finally, molecular mechanism was revealed tagged RNA affinity purification (TRAP), western blot, immunoprecipitation, dual luciferase reporter...
Estrogen deficiency is one of the major causes osteoporosis in postmenopausal women. Drynariae Rhizoma a widely used traditional Chinese medicine for treatment bone diseases. In this study, we investigated therapeutic effects total flavonoids (DRTF) on estrogen deficiency-induced loss using an ovariectomized rat model and osteoblast-like MC3T3-E1 cells. Our results indicated that DRTF produced osteo-protective rats terms reduction, including decreased levels turnover markers, enhanced...
Chaihu-Longgu-Muli Decoction (CLMD) is a classic prescription created by Zhong-jing Zhang, famous ancient Chinese medical scientist, to harmonize uncontrollable body activities and calm the minds. Now Traditional Medicine (TCM) physicians often apply it treat psychiatric diseases such as epilepsy.
This study investigated the protective effects of aged
Type 1 diabetes (T1D) is a T cell-mediated autoimmune disease. Increased incidence of T1D was reported in patients receiving IFN-α treatment. However, the exact mechanisms that facilitate pathogenesis are not fully understood. To explore mechanism on immune system and islets, non-obese diabetic (NOD) mice were injected with progression insulitis assessed by haematoxylin eosin (HE) staining, immunohistochemical flow cytometry analysis. Transcriptional profiling islets treated explored...
Background : The pathogenesis of Alzheimer’s disease (AD) remains to be elucidated. This study aimed identify the hub genes in AD and determine their functions pathways. Methods A co-expression network for an gene dataset with 401 samples was constructed, status-related were screened. identified validated by independent cohort. functional pathways analyzed. Results revealed a module that related status, 101 screened from trait-related module. Gene enrichment analysis indicated these are...
Abstract Background Lung adenocarcinoma (LUAD) is a common subtype of non‐small cell lung cancer with high morbidity and mortality rates usually detected at advanced stages because the early onset metastasis. Adenosine deaminase RNA‐specific 1 (ADAR1) an RNA editing enzyme that catalyzes important physiological process adenosine‐to‐inosine has been shown to participate in progression LUAD. Increasing evidence suggested immune infiltration tumor microenvironment prognostic value for most...
Inflammatory processes associated with the over-production of cytokines, particularly TNF-alpha, accompany numerous neurodegenerative diseases, such as Alzheimer's disease, in addition to systemic conditions, exemplified by rheumatoid arthritis and erythema nodosum leprosum (ENL). TNF-alpha has been validated a drug target Remicade Enbrel available prescription medications. Both, however, are large macromolecules, require injection have limited brain access. The classical drug, thalidomide...
A major pathological hallmark of Alzheimer disease (AD) is the appearance in brain senile plaques that are primarily composed aggregated forms β-amyloid peptide (Aβ) derive from amyloid precursor protein (APP). Posiphen (1) tartrate an experimental AD drug current clinical trials reduces Aβ levels by lowering rate APP synthesis without toxicity. To support development and elucidate its efficacy, three metabolic products, (+)-N1-norPosiphen (15), (+)-N8-norPosiphen (17) (+)-N1,...
Pericarpium Citri Reticulatae ‘Chachi’ (PCR-C), rich in polymethoxyflavones (PMFs), has potential anticancer bioactivity and its quality will be improved during storage. However, the main factors influencing PCR-C storage remain unclear. In this study, multivariate analysis was performed to investigate free bound PMFs of The effects purified flavonoid extracts (PCR-CF) important were evaluated using A549 cells. results showed that samples exhibited remarkable differences storage, which fell...
Elucidation of signaling pathways that control oligodendrocyte (OL) development is a prerequisite for developing novel strategies myelin repair in neurological diseases. Despite the extensive work outlining importance Hedgehog (Hh) commitment and generation OL progenitor cells (OPCs), there are conflicting reports on role Hh regulating differentiation maturation. In present study, we systematically investigated OPC specification genetically modified mouse models Smoothened (Smo), an...
The mechanisms underlying autophagic defects in nonalcoholic steatohepatitis (NASH) remain largely unknown. We aimed to elucidate the roles of hepatic cyclooxygenase 1 (COX1) autophagy and pathogenesis diet-induced mice. Human fatty liver disease (NAFLD) samples were used examine protein expression COX1 level autophagy. Cox1Δhepa mice their wildtype littermates generated fed with 3 different NASH models. found that was increased patients models accompanied by impaired required for basal...
Elastic cartilage tissue engineering is promising for providing available scaffolds plastic reconstructive surgery. The insufficient mechanical strength of regenerative and scarce resources reparative cells are two obstacles the preparation tissue-engineered elastic scaffolds. Auricular chondrocytes important engineering, but scarce. Identifying auricular with enhanced capability formation conducive to reducing damage donor sites by decreasing demand on native isolation. Based biochemical...
HSP90 protects the cells from heat stress and facilitates protein maturation stability. The full genome sequences of piroplasms contain two putative proteins, which are yet uncharacterized. To this end, proteins Babesia orientalis were identified characterized by molecular in silico methods. B. showing homology with other cloned sequenced. A computational analysis was carried out to predict antigenic determinants, structure function these proteins. interactions isoforms respective inhibitors...
Osteoarthritis (OA) is a common age-related joint disease characterized by destruction and impaired quality of life. Angiogenesis plays vital role in OA progression. This study aimed to identify key angiogenesis-related genes (ARGs) using transcriptomic machine learning methods.
Objectives: The reprogramming of lipid metabolism is a new trait cancers. However, the role in tumor immune microenvironment (TIME) and prognosis gastric cancer remains unclear. Methods: Consensus clustering was applied to identify novel subgroups. ESTIMATE, TIMER, MCPcounter algorithms were used determine TIME underlying mechanisms elucidated using functional analysis. prognostic model established LASSO algorithm multivariate Cox regression Results: Three molecular subgroups with...