Abstract Non-small cell lung cancer (NSCLC) is the most widely distributed tumor in world, and its immunotherapy not practical. Neutrophil one of a tumor’s abundant immune groups. This research aimed to investigate complex communication network microenvironment (TIME) NSCLC tumors clarify interaction between cells establish prognostic risk model that can predict response prognosis patients by analyzing characteristics differentiation. Integrated Single-cell RNA sequencing (scRNA-seq) data...

Ovarian cancer (OC) is one of the most common gynecological malignancies. It associated with a difficult diagnosis and poor prognosis. Our study aimed to analyze tumor stemness determine prognosis feature patients OC. At this job, we selected gene expression clinical profiles OC in TCGA database. We calculated index each patient using one-class logistic regression (OCLR) algorithm performed correlation analysis immune infiltration. used consensus clustering methods classify into different...

Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive malignant tumors in digestive tract, characterized by a high recurrence rate and inadequate immunotherapy options. We analyzed mutation data ESCC from public databases employed 10 machine learning algorithms to generate 101 algorithm combinations. Based on optimal range determined concordance index, we randomly selected combination best-performing construct prognostic model consisting five genes (DLX5, MAGEA4, PMEPA1,...

Abstract Background Allergic diseases typically refer to a heterogeneous group of conditions primarily caused by the activation mast cells or eosinophils, including atopic dermatitis (AD), allergic rhinitis (AR), and asthma. Asthma, AR, AD collectively affect approximately one‐fifth global population, imposing significant economic burden on society. Despite availability drugs treat diseases, they have been shown be insufficient in controlling relapses halting disease progression. Therefore,...

<i>Background:</i> The modulatory domain of the human androgen receptor (AR) gene contains a polymorphic CAG repeat coding for polyglutamine tract which is inversely correlated with transcriptional activity AR. Androgens acting through AR play crucial role in pathogenesis acne vulgaris. We therefore investigated relationship between polymorphism <i>AR</i> and susceptibility. <i>Methods:</i> 206 patients 200 controls participated study. Genomic DNA was...

Pu-erh tea is a kind of fermented with the incorporation microorganisms' metabolites. Unlike green tea, chemical characteristics and bioactivities are still not well understood. Using water extracts we analyzed tumor cell growth inhibition activities on several genetically engineered mouse lines. We found that at concentration did affect wild type embryo fibroblasts (MEFs) growth, could inhibit by down-regulated S phase cause G1 or G2 arrest. Further study showed expression mutant p53 in...

p53 is a tumor suppressor gene and plays important roles in the etiology of breast cancer. Studies have produced conflicting results concerning role codon 72 polymorphism (G>C) on risk cancer; therefore, meta-analysis was performed to estimate association between Screening PubMed database conducted identify relevant studies. containing available genotype frequencies were selected pooled odds ratio (OR) with 95% confidence interval (CI) used assess association. Sixty-one published studies,...

<i>Background:</i> Although many arguments have been raised on the role of heredity in etiology acne, relevant genetic elements pathogenesis disease are not well established. <i>Objective:</i> The aim our study was to evaluate association between a polymorphism promoter region CYP17 gene and development acne. <i>Methods:</i> 206 acne patients 200 controls were included study. A polymerase chain reaction (PCR) sequencing technique used reveal its region....

It is just in recent years that mitochondrial DNA (mtDNA) mutations have been found solid tumors. Although a direct link between the presence of mtDNA and development tumors has not made, might prove significant detection tumor recurrence possibly genotoxic damage. To investigate relationship variation endometrial cancer, we collected blood samples from subjects with Han native background Yunnan province China, 49 them pathologically conformed cancer 31 as controls no disease sequenced two...

Nine new triterpene derivatives, yunnanterpenes A-F (1-6), 15,16-seco-cimiterpenes A and B (7, 8), cimilactone C (9), 15 known analogues (10-24) were isolated from the aerial parts of Cimicifuga yunnanensis. The structures established using a combination MS, NMR, single-crystal X-ray diffraction techniques. WT MEFs (wild-type mouse embryonic fibroblasts) tumorigenic cell lines p53(-/-)+H-RasV12 p53(-/-)+p53(N236S)+H-RasV12 used for evaluating active structures, targeting p53(N236S)...

Abstract Triple-negative breast cancer (TNBC) is highly malignant and lacks effective biotherapeutic targets. The development of efficient anticancer drugs with low toxicity few side effects a hotspot in TNBC treatment research. Although erianin known to have potent antitumor activity, its regulatory mechanism target not been fully elucidated, hampering further drug development. This study showed that can significantly inhibit cell proliferation migration, promote apoptosis, the growth...

Objective The human β2-adrenergic receptor (ADRB2) gene is a candidate for contributing to the pathophysiology of essential hypertension. aims present study were investigate associations differing single nucleotide polymorphisms (SNPs) and haplotypes ADRB2 promoter coding regions with hypertension in genetically homogeneous Hani Yi minority groups that are non-Han Chinese. Methods Four SNPs regulatory seven region genotyped 271 individuals 267 controls, eight five determined tested...

p16Ink4a is a tumor suppressor and marker for cellular senescence. Previous studies have shown that plays an important role in the response to DNA damage signals caused by telomere dysfunction. In this study, we crossed Wrn−/− p16Ink4a−/− mice knock out function Wrn null background. Growth curves showed loss of could rescue growth barriers are observed mouse embryonic fibroblasts (MEFs). By challenging MEFs with global genotoxin doxorubicin, did not dramatically affect induced doxorubicin....