A5002431822- Polysaccharides and Plant Cell Walls
- Natural product bioactivities and synthesis
- Plant Toxicity and Pharmacological Properties
- Phytochemicals and Antioxidant Activities
- Biological Activity of Diterpenoids and Biflavonoids
- Sesquiterpenes and Asteraceae Studies
- Morinda citrifolia extract uses
- Chemical Reaction Mechanisms
- Aldose Reductase and Taurine
- Moringa oleifera research and applications
- Nuts composition and effects
- Plant Gene Expression Analysis
- Antioxidant Activity and Oxidative Stress
- Bioactive Compounds and Antitumor Agents
- Adrenal Hormones and Disorders
- Salivary Gland Tumors Diagnosis and Treatment
- Hydraulic and Pneumatic Systems
- Synthesis and Biological Activity
- IgG4-Related and Inflammatory Diseases
- Thyroid Disorders and Treatments
- Organic and Inorganic Chemical Reactions
- Diabetes and associated disorders
- Plant biochemistry and biosynthesis
- Gear and Bearing Dynamics Analysis
- Tribology and Lubrication Engineering
Peking University
2001-2023
National Clinical Research Center for Digestive Diseases
2022
Central South University
2019-2021
Kunming University of Science and Technology
2013
Beijing National Laboratory for Molecular Sciences
2007
Taurine and substituted taurines were synthesized efficiently from aziridines via ring-opening reaction with thioacetic acid, oxidation performic hydrolysis in hydrochloric acid. The current method shows more benefit purification efficiency the preparation of taurine structurally diverse 2-substituted, 2,2-disubstituted, 1,2-, 2,2-, 2,N-alkylene taurines.
Nine new triterpene derivatives, yunnanterpenes A-F (1-6), 15,16-seco-cimiterpenes A and B (7, 8), cimilactone C (9), 15 known analogues (10-24) were isolated from the aerial parts of Cimicifuga yunnanensis. The structures established using a combination MS, NMR, single-crystal X-ray diffraction techniques. WT MEFs (wild-type mouse embryonic fibroblasts) tumorigenic cell lines p53(-/-)+H-RasV12 p53(-/-)+p53(N236S)+H-RasV12 used for evaluating active structures, targeting p53(N236S)...
Three previously undescribed dammarane triterpenoid glycosides (1-3) along with five known analogues (4-8) were isolated from the leaves of Cyclocarya paliurus. Their structures and configurations determined on basis comprehensive spectroscopic analyses, chemical hydrolysis DFT GIAO 13C NMR calculation. All isolates evaluated cytotoxic activities against seven human cancer cell lines (MCF-7, PC-3, Du145, NCI-H1975, PC-9, SKVO3 HepG2). Moreover, compound 4 showed a wide spectrum cytotoxicity...
Four new prenylflavonol glycosides (1-4) along with two known analogues (5-6) were isolated from the leaves of Cyclocarya paliurus for first time. The structures these compounds characterized by comprehensive analysis 1 D, 2 D NMR, HRESIMS, UV data and enzymatic hydrolysis. In bioassays, 1-4 evaluated inhibitory effects on xanthine oxidase (XOD) inhibition nitric oxide (NO) production in lipopolysaccharide (LPS) induced RAW264.7 cells. Moreover, showed outstanding XOD inhibitions IC50 values...
Phytochemical investigation of the rhizomes and roots Ligularia veitchiana afforded a new triterpenoid saponin two known neolignans named liguveitoside B (1), citrusin A (2) (3), respectively. This is first demonstration occurrence 8-O-4’ neolignan second report on isolation in genus Ligularia. Their structures were elucidated basis spectral data, particularly HSQC, HMBC NOE experiments. Compound 1 exhibited weak cytotoxicity against human acute promyelocytic leukemia cell-line (HL-60).
Abstract A practical method for the total synthesis of pisiferic acid type diterpenoids is described. This involves Robinson annulation keto ester key intermediate.
Two dammarane glycosides (1-2) were isolated from the leaves of Cyclocarya paliurus. The structures new compounds established by application spectroscopic methods, including one-dimensional and two-dimensional NMR, HRESIMS, chemical hydrolysis. When evaluated against seven human cancer cell lines, two exhibited selective cytotoxicity to MCF-7 cells.[Formula: see text].
Abstract Under-race lubrication is an efficient method of aeroengine bearings for achieving high DN values. In this paper, experimental study on oil supply efficiency under-race structure based rotation speed and small size radial scoop carried out. The influence speed, nozzle diameter temperature are analysed. research results can be used to guide the design structure.
A new sesquiterpene lactone (1) was obtained from the cytotoxic fraction of 95% ethanol extract root barks Tsoongiodendron odorum Chun together with two known lactones, costunolide (2) and parthenolide (3). The structure 1 elucidated as 5alpha, 6alpha, 7beta, 10beta- 11alpha, 13-dihydro-4(15)-eudesmene-12, 6-olide on basis chemical spectral evidence including X-ray diffraction analysis. Costunolide showed activity against human leukemia (HL-60) cell line. Parthenolide promising activities in...
Environment planning is highly related with city building that influences low-carbon and green architecture design. Hokkaido in Japan Guangdong China are two regions reflect different ways of cooperation environment strategy due to regional characters. adopts compact definite transport balance rural development. plans greenway as important linear element uniform the appearance. Through relative cases we could analyze kinds references for other on account specific
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