A5114585239- Cancer-related Molecular Pathways
- Epigenetics and DNA Methylation
- Telomeres, Telomerase, and Senescence
- Cancer Cells and Metastasis
- Chromosomal and Genetic Variations
- DNA Repair Mechanisms
- Plant Disease Resistance and Genetics
- Cancer-related gene regulation
- Folate and B Vitamins Research
- Plant tissue culture and regeneration
- RNA modifications and cancer
- Prenatal Screening and Diagnostics
- Gestational Diabetes Research and Management
- Cytokine Signaling Pathways and Interactions
- Cancer Research and Treatments
- Microbial Natural Products and Biosynthesis
- Digestive system and related health
- Carbohydrate Chemistry and Synthesis
- Plant Molecular Biology Research
- Vector-borne infectious diseases
- Cancer-related molecular mechanisms research
- Immune cells in cancer
- Photosynthetic Processes and Mechanisms
- Nitrogen and Sulfur Effects on Brassica
- Immune Response and Inflammation
Kunming University of Science and Technology
2015-2025
Oil Crops Research Institute
2016-2024
Chinese Academy of Agricultural Sciences
2011-2024
Ministry of Agriculture and Rural Affairs
2024
Affiliated Hospital of Hebei University
2024
Anhui Medical University
2024
AbbVie (United States)
2021-2023
Liaoning Cancer Hospital & Institute
2021
China Medical University
2021
Shanghai First People's Hospital
2021
Ulcerative colitis and Crohn's disease, collectively known as inflammatory bowel disease (IBD), are chronic disorders of the intestine for which key elements in initiation perpetuation defects epithelial barrier integrity. Achieving mucosal healing is essential to ameliorate outcome so new therapies leading homeostasis repair under investigation. This study was designed determine mechanisms by IL-22 regulates intestinal cell function.Human organoids resections, well mice were used evaluate...
Downregulation of P-glycoprotein (P-gp) is implicated in the pathophysiology inflammatory bowel disease (IBD). Berberine, a principal isoquinoline alkaloid extracted from <i>Berberis</i> species, has been reported to exhibit therapeutic potential IBD. In this study, we used dextran sulfate sodium (DSS)-induced colitis rat model evaluate effect berberine on P-gp and explore its mechanism action. Berberine treatment improved DSS-induced symptoms, attenuated markers (myeloperoxidase, tumor...
Diligent side-by-side comparisons of how different methodologies affect growth efficiency and quality intestinal colonoids have not been performed leaving a gap in our current knowledge. Here, we summarize efforts to optimize culture conditions for improved functional differentiation mouse human colon organoids.Mouse organoids were grown four media. Media-dependent long-term was measured by quantifying surviving via imaging cell viability readout over five passages. The impact diverse media...
Abstract Little is known about the mechanism of drought tolerance in rapeseed ( Brassica napus L.). In this study, different morphological and physiological responses to stress were studied three cultivars. For cultivar 2AF009 with high tolerance, comparative proteomic analyses conducted determine molecular behind. Approximately 138 differentially abundant proteins (DAPs) 1232 phosphoproteins containing 4469 phosphopeptides identified. Furthermore, 337 547 phosphorylation sites demonstrated...
Abstract Cancer-associated fibroblasts (CAFs) are critical components of the tumor microenvironment (TME), playing significant roles in regulating cancer progression. However, underlying mechanism CAFs activation remains elusive. In this study, we aim to investigates mechanisms by which promote conversion normal (NFs) lung cancer, with a focus on role p53 mutations and CXCL12/STAT3 signaling axis. We found that significantly induced NFs acquire properties (called CEFs), including...
The study was conducted to investigate the physiological effects of exogenous NO on potherb mustard (Brassica juncea Coss.) seedlings under salt stress. plants were grown in Hogland nutrient solution for 15 d and treated with 150 mM NaCl, donor sodium nitropruside (SNP) scavenger methylene blue (MB-1) 4 d. NaCl stress increased superoxide dismutase, peroxidase ascorbate activities malondialdehyde (MDA) free proline contents, decreased soluble protein content. However, application limited...
Cancer-associated fibroblasts (CAFs) play important roles in cancer development and progression. Recent studies show that p53 plays a cell non-autonomous tumor-suppressive role to restrict tumor growth CAFs. However, the of mutant CAFs remains obscure.In this study, contribution p53N236S (p53S) activation was examined using mouse embryonic (MEFs) from wild-type (WT), deficient (p53-/- ) p53S/S mice. The p53S MEFs inducing prostate metastasis studied by utilizing xenograft models transwell...
Aging has been recently reported to promote lung cancer initiation and progression. Senescent fibroblasts gain a cancer-associated fibroblast (CAF) phenotype, exert powerful influence on behavior, such as tumor cell growth metastasis. However, mechanisms linking senescence with CAF activation remain poorly understood. Our study shows that senescent displayed properties, including the highly expressed markers, α-SMA Vimentin, CAF-specific factors, CXCL12, FGF10, IL6 COL1A1, which...
p16Ink4a is a tumor suppressor and marker for cellular senescence. Previous studies have shown that plays an important role in the response to DNA damage signals caused by telomere dysfunction. In this study, we crossed Wrn−/− p16Ink4a−/− mice knock out function Wrn null background. Growth curves showed loss of could rescue growth barriers are observed mouse embryonic fibroblasts (MEFs). By challenging MEFs with global genotoxin doxorubicin, did not dramatically affect induced doxorubicin....
[reaction: see text] Gramicidin S is a potent decapeptide antibiotic with high hemolytic activity but unlikely to provoke microbial resistance. Here we demonstrate that gramicidin thioesterase (GrsB TE) correctly cyclizes immobilized linear precursors into head-to-tail products, indicating its suitability for parallel solid-phase synthesis of analogues from on solid support. This chemoenzymatic method will enable the optimization therapeutic index natural product fight
A simple and efficient preparation of gramicidin S its analogues is described. It involves solid-phase peptide synthesis on-resin macrolactamization without side chain protection, affording cyclic products in high yield purity. The specificity the cyclization reaction was shown to originate formation a pre-organized conformation linear biosynthetic precursor S. This facile method will provide convenient access natural product for functional optimization counter microbial resistance.
The p53 is one of the most important tumor suppressors through surveillance DNA damages and abnormal proliferation signals, activation cell cycle arrest apoptosis in response to stress.However, mutation known be oncogenic by both loss function inhibiting progress gain promoting proliferation.In present study, we have established a knock mouse model containing an Asn-to-Ser substitution at amino acid 236 homologous recombination (p53N236S).Other than tumorigenesis phenotype, found that S/S...
The present study aimed to investigate the effects of p16 hypermethylation on risk nasopharyngeal carcinoma (NPC) quantitatively, through a meta‑analysis available case‑control studies including malignant and normal NPC tissue samples. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were extracted pooled assess strength association between risk. A total 9 studies, 406 376 control cases, identified for meta‑analysis. Statistically significant ORs obtained from groups (OR=19.53;...
Human Werner syndrome (WS) is an autosomal recessive progeria disease. A mouse model of WS manifests the disease through telomere dysfunction-induced aging phenotypes, which might result from cell cycle control and cellular senescence. Both p21 Waf1/Cip1 (p21, encoded by Cdkn1a gene) p16 Ink4a (p16, are inhibitors involved in regulating two key pathways To test effect deficiencies WS, we crossed mice (DKO) with –/– or to construct triple knockout (p21-TKO p16-TKO) mice. By studying survival...
Glycyrrhetin urea has emerged as a privileged scaffold with anti-inflammatory activity for the treatment and prevention of acute kidney injury (AKI). In this study, structural modifications A ring glycyrrhetinic acid yielded series derivatives, among which compound 7o exhibited most promising activity. was confirmed to interact STING through cellular heat shift assay inhibit STING/NF-κB pathway in RAW264.7 cells. It acted on pathway, inhibited NF-κB phosphorylation, subsequently reduced...