A5114107790- Telomeres, Telomerase, and Senescence
- RNA modifications and cancer
- Mycobacterium research and diagnosis
- Plant-based Medicinal Research
- Microbial infections and disease research
- Healthcare and Venom Research
- Medicinal Plants and Bioactive Compounds
- RNA Research and Splicing
- Traditional Chinese Medicine Analysis
- Mitochondrial Function and Pathology
- Metabolomics and Mass Spectrometry Studies
- RNA Interference and Gene Delivery
- Cancer-related Molecular Pathways
- Genetics, Aging, and Longevity in Model Organisms
- Genomics and Chromatin Dynamics
- Antimicrobial Resistance in Staphylococcus
- Infective Endocarditis Diagnosis and Management
- DNA Repair Mechanisms
- Epigenetics and DNA Methylation
- Digestive system and related health
Guiyang Medical University
2021-2025
Genomic instability is the main cause of abnormal embryo development and abortion. NLRP7 dysfunctions affect embryonic lead to Hydatidiform Moles, but underlying mechanisms remain largely elusive. Here, we show that knockout affects genetic stability, resulting in increased DNA damage both human stem cells blastoids, making blastoids more susceptible apoptosis. Mechanistically, can interact with factors related alternative splicing response, including DDX39B, PRPF8, THRAP3 PARP1. Moreover,...
Genomic libraries of two Enterococcus faecalis strains, OG1RF and TX52 (an isolate from an endocarditis patient), were constructed in cosmid vectors pBeloBAC11 pLAFRx, screened with a serum rabbit immunized surface proteins E. sera four patients enterococcal endocarditis. Seventy-five clones reacted at least the sera. Thirty-eight 75 immunopositive considered to contain distinct inserts based on their DNA restriction patterns chosen for further subcloning into pBluescript vector. Each...
Anti-aging and tumorigenesis share common genes pathways, thus targeting these as part of anti-aging interventions carries the risk tumorigenesis. It is essential to understand gene signatures that balance aging. To achieve this goal, we analyzed RNA-sequencing data from three non-tumorigenic immortalized cell lines spontaneously escaped senescence. By single sample set enrichment assay (ssGSEA) GSEA analysis, found both growth signaling (E2F targets, MYC targets) tumor surveillance...
The balancing between tumor suppression and cell viability is the key to balance aging tumorigenesis, reach tumor-free longevity, or healthy aging. We speculate that of signaling growth sustaining mechanisms in molecular genetics might reflect Yin Yang Chinese medicine. Some medicine herbs are known sustain help prevent related diseases, such as Panax Ginseng, Ganoderma Lucidum etc. Based on databases signature database, we try apply silico systems pharmacology analyze function these...