A5005878000- Toxoplasma gondii Research Studies
- Liver Disease Diagnosis and Treatment
- Drug-Induced Hepatotoxicity and Protection
- Liver physiology and pathology
- Traditional Chinese Medicine Studies
- Autophagy in Disease and Therapy
- Neuroinflammation and Neurodegeneration Mechanisms
- Herpesvirus Infections and Treatments
- Immune Response and Inflammation
- MicroRNA in disease regulation
- NF-κB Signaling Pathways
- Inflammasome and immune disorders
- Histone Deacetylase Inhibitors Research
- Bacteriophages and microbial interactions
- Rabies epidemiology and control
- Gut microbiota and health
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- interferon and immune responses
- RNA Interference and Gene Delivery
- Therapeutic Uses of Natural Elements
- Hepatitis B Virus Studies
- Heat shock proteins research
- Connective Tissue Growth Factor Research
- Vibration and Dynamic Analysis
Anhui Medical University
2018-2025
Jiangxi University of Traditional Chinese Medicine
2020-2024
Nanjing University
1998-2024
Soochow University
2024
First Affiliated Hospital of Soochow University
2024
First Affiliated Hospital of Anhui Medical University
2023
Sichuan University
2021-2023
West China Hospital of Sichuan University
2023
University of Science and Technology of China
2023
Shanghai East Hospital
2019-2022
Diabetic nephropathy (DN) is prevalent in patients with diabetes. N6-methyladenosine (m6A) methylation has been found to cause modification of nucleotide-binding oligomerization domain, leucine-rich repeat, and pyrin domain-containing (NLRP) 3, which involved cell pyroptosis inflammation. WTAP a key gene modulating NLRP3 m6A.In this study, was silenced or overexpressed high glucose (HG)-treated HK-2 cells determine its influence on pyroptosis, inflammasome-related proteins, the release...
COVID-19 has infected 272 million patients and caused 5.33 deaths around the world, it remains main global threat. Previous studies revealed that Chinese traditional medicine is an effective treatment for infection. This study aims to reveal pharmacological effects of kaempferol, which active component Radix Bupleuri Tripterygii Radix, potential mechanisms COVID-19. Here, we employed bioinformatics methods filter anti-COVID-19 candidate genes mainly enriched in inflammation (TNF, JUN, etc.)...
Abstract The gut–brain axis is a bidirectional communication system between the gut and central nervous system. Many host-related factors can affect microbiota, including oral bacteria, making brain vulnerable target via axis. Saliva contains large number of periodontitis, common disease, change composition salivary microbiota. However, role mechanism periodontitis microbiota (PSM) on remain unclear. Herein, we investigated nature mechanisms this relationship using mice with dextran sulfate...
Objective: Nonalcoholic fatty liver disease (NAFLD) is a prevalent condition worldwide, and the statistics show that men have higher incidence prevalence than women, but its toxicological mechanism not completely clear. This research intended to explore role of BaP in NAFLD study how environmental pollutant influences AHR/ERα axis mediate progression NAFLD. Methods: In this study, we established models vivo vitro by treating HepG2 cells with high-fat diet Oleic acid (OA) C57BL/6J mice. Liver...
Abstract Hashimoto’s thyroiditis (HT) is the most common organ-specific autoimmune disease, predominantly affecting women. Although pathogenesis of HT incompletely understood, some studies have found that macrophage polarization plays a role. Puerarin soy isoflavone compound has anti-inflammatory and immunomodulatory effects regulates immune activity. This study aimed to verify therapeutic effect puerarin on explored its regulatory imbalance in HT. Through bioinformatics analysis molecular...
Toxoplasma gondii is a protozoan parasite that causes severe diseases in mammals, including humans, around the world. In China, pork main meat source; accordingly, T. pigs considered an important source for human toxoplasmosis. Understanding epidemiology of toxoplasmosis pig farms thus control disease humans. The purpose present study was to investigate epizootiology infections central China by assessing seroprevalence and risk factors this disease. study, 3,558 sera samples were collected...
Alzheimer's disease presents an abnormal cognitive behavior. TgCtwh6 is one of the predominant T. gondii strains prevalent in China. Although type II strain infection can cause host behavioral abnormalities, we do not know whether could also changes. So, this study, will focus on effect mouse behavior and try vivo vitro to explore underlying mechanism by which give rise mice changes at cellular molecular level.C57BL/6 were infected orally with cysts. From day 90 post-infection on, all...
Abstract Background Yi Guan Jian Decoction (YGJD), a famous Chinese prescription, has long been employed clinically to treat liver fibrosis. However, as of date, there is no report on the effects YGJD from metabonomic approach. In this study, urine method based gas chromatography coupled with mass spectrometry (GC/MS) was study protective efficacy and metabolic profile changes caused by in carbon tetrachloride (CCl 4 )-induced Methods Urine samples Wistar rats three randomly divided groups...
Abstract Numb, a stem cell fate determinant, acts as tumor suppressor and is closely related to wide variety of malignancies. Intrahepatic cholangiocarcinoma (iCCA) originates from hepatic progenitors (HPCs); however, the role Numb in HPC malignant transformation iCCA development still unclear. A retrospective cohort study indicated that was frequently decreased tissues suggests poor prognosis patients. Consistently, chemically induced mouse model, downregulated cells compared normal...
Objective. This study was to define the protective effect of purified Helvella leucopus polysaccharide (p-HLP) against dextran sulfate sodium- (DSS-) induced colitis. Methods. The novel p-HLP isolated from Bachu mushroom through hot water extraction, ethanol precipitation, and column chromatography. Then, we evaluated potential effects on colonic histopathology, inflammation, microbiota composition in DSS-induced colitis mice. Results. a homopolysaccharide with an average molecular weight...
HSP90 protects the cells from heat stress and facilitates protein maturation stability. The full genome sequences of piroplasms contain two putative proteins, which are yet uncharacterized. To this end, proteins Babesia orientalis were identified characterized by molecular in silico methods. B. showing homology with other cloned sequenced. A computational analysis was carried out to predict antigenic determinants, structure function these proteins. interactions isoforms respective inhibitors...
AIM:To evaluate the effect of Chinese traditional medicinal prescription, JIANPI HUOXUE decoction (JHD) on cytokine secretion pathway in rat liver induced by lipopolysaccharide (LPS).METHODS: Twenty-four male SD rats were divided into normal group (n = 4), model 10) and JHD randomly.Rats administrated with saline or via gastrogavage respectively twice a day for 3 d.One hour after last administration, injected LPS tail vein, 50 µg/kg.Simultaneously, equivalent saline.After stimulation 1.5 h,...
Our previous investigations indicated that in vitro polarization of mouse macrophages by Toxoplasma gondii type Ⅱ strain dense granule protein 15 (GRA15Ⅱ), one the genotype-associated effectors T. gondii, induced phenotypes classically activated macrophage (M1). Transfusion cells to mice may effectively alleviated hepatic fibrosis caused schistosomiasis. The purpose study was identify whether liver can be vivo driven M1 lentiviral vector (LV) carrying GRA15Ⅱ gene (LV-gra15Ⅱ) and explore...
Abstract Background Hepatocellular carcinoma (HCC), the most common primary liver cancer, prevails mainly in males and has long been attributed to androgens higher circumstantial levels of interleukin-6 (IL-6) produced by resident hepatic macrophages. Methods Constitutively hepatocyte-specific histone deacetylase 3 (HDAC3)-deficient ( HDAC3 LCKO ) mice constitutively knockout systemic IL-6 simultaneously ablated & −/− were used our study explore causes sex differences HCC. Additionally,...