A5031414341- Ferroptosis and cancer prognosis
- CAR-T cell therapy research
- RNA modifications and cancer
- Histone Deacetylase Inhibitors Research
- Glioma Diagnosis and Treatment
- MicroRNA in disease regulation
- Immunotherapy and Immune Responses
- Cancer Mechanisms and Therapy
- Chemical Synthesis and Characterization
- Neuroblastoma Research and Treatments
- Epigenetics and DNA Methylation
- Nanowire Synthesis and Applications
- Cancer-related molecular mechanisms research
- Extraction and Separation Processes
- Immune cells in cancer
- Immune Cell Function and Interaction
- Traumatic Brain Injury and Neurovascular Disturbances
- interferon and immune responses
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- T-cell and B-cell Immunology
- RNA Interference and Gene Delivery
- Cancer, Hypoxia, and Metabolism
- Peptidase Inhibition and Analysis
- RNA regulation and disease
Sichuan University
2018-2024
First Affiliated Hospital of GuangXi Medical University
2023-2024
Guangxi Medical University
2023-2024
West China Hospital of Sichuan University
2018-2024
Gansu Agricultural University
2024
Fourth Affiliated Hospital of Guangxi Medical University
2023
Henan Provincial People's Hospital
2021-2023
Qingdao University
2014-2023
Affiliated Hospital of Qingdao University
2015-2023
Nanjing Children's Hospital
2023
Viral infection triggers the formation of mitochondrial antiviral signaling protein (MAVS) aggregates, which potently promote immune signaling. Autophagy plays an important role in controlling MAVS-mediated signaling; however, exact molecular mechanism underlying targeted autophagic degradation MAVS remains unclear. Here, we investigated by RNF34 regulates immunity and mitophagy targeting MAVS. binds to compartment after viral negatively RIG-I-like receptor (RLR)-mediated immunity. Moreover,...
Abstract Histone deacetylase 3 (HDAC3) plays pivotal roles in cell cycle regulation and is often aberrantly expressed various cancers including hepatocellular carcinoma (HCC), but little known about its role liver regeneration cancer cells proliferation. Using an inducible hepatocyte-selective HDAC3 knockout mouse, we find that lack of dramatically impaired blocked hepatocyte proliferation the G1 phase entry. inactivation robustly disrupted signal transducer activator transcription (STAT3)...
Abstract DNA damage triggers diverse cancers, particularly hepatocellular carcinoma (HCC), but the intrinsic link between and tumorigenesis remains unclear. Because of its role as an epigenetic transcriptional regulator, histone deacetylase 3 (HDAC3) is essential for control often aberrantly expressed in human HCC. In this study, we used individual class I HDAC member–deficient mice to demonstrate that K9 H3 (H3K9), which critical site assembly response complexes, exclusively targeted by...
Berberine (BBR) has a neuroprotective effect against ischemic stroke, but its specific protective mechanism not been clearly elaborated. This study explored the of BBR on canopy FGF signaling regulator 2 (CNPY2) pathway in penumbra rats. The model cerebral ischemia-reperfusion injury (CIRI) was established by thread embolization method, and gastrically perfused for 48 h or 24 before operation 6 after operation. rats were randomly divided into four groups: Sham group, CIRI + group. After...
Pancreatic cancer is a highly lethal solid malignancy with limited treatment options. Chimeric antigen receptor T (CAR-T) cell therapy has been successfully applied to treat hematological malignancies, but faces many challenges in tumors. One major challenge the shortage of tumor-selective targets. Cell surface GRP78 (csGRP78) expressed on various cells including pancreatic cancer, not normal cells, providing potential target for CAR-T cancer. Here, we demonstrated that csGRP78-directed...
Acute liver failure (ALF) is a complicated clinical syndrome associated with high mortality, transplantation as the only treatment option. Treatment of mesenchymal stem cells has shown potential therapeutic option for acute failure. However, lack random trials and large non-human primate studies makes it necessary to assess efficacy safety in clinic.We treated monkeys peripheral delivery human umbilical MSCs (hUC-MSCs) investigated role hUC-MSCs modulating progress failure.The use early...
Chimeric antigen receptor (CAR) T-cell therapy is emerging as an effective cancer treatment, such for hematological malignancies, however its effectiveness approach to treat solid tumors, in colorectal (CRC), remains be better developed. One area of intense development has been the identification and characterization novel cancer-related ligand receptors CAR design evaluation. It known that CD6 CD166 CD318 are highly expressed CRC, several CAR-Ts have also explored preclinical clinical...
Abstract Lung adenocarcinoma (LUAD) is characterized by a high incidence rate and mortality. Recently, POC1 centriolar protein A (POC1A) has emerged as potential biomarker for various cancers, contributing to cancer onset development. However, the association between POC1A LUAD remains unexplored. We extracted The Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO) data sets analyse differential expression of its relationship with clinical stage. Additionally, we performed diagnostic...
Ovarian cancer (OC) is characterized by its rapid growth and spread which, accompanied a low 5-year survival rate, necessitates the development of improved treatments. In ovarian cancer, selective overexpression Mucin-16 (MUC16, CA125) in tumor cells highlights potential as promising target for developing anti-tumor therapies. However, effectiveness CAR-T cell therapy that targets MUC16 unknown.
Triptolide (TP) has been used in the treatment of rheumatoid arthritis (RA), but its mechanism action is not understood. T-cell activation and associated release cytokines appear to be major factors pathogenesis RA. The overexpression receptor (TCR) variable gene (V gene) fragments can cause infiltration autoreactive T cells. This study examines effects TP on rats with collagen-induced (CIA). levels interleukin-10 (IL-10) serum were examined ELISA. Compared CIA group, IL-10 greater group....
Estrogen-related receptor α (ERRα) is a member of the nuclear superfamily controlling energy homeostasis; however, its precise role in regulating antiviral innate immunity remains to be clarified. Here, we showed that ERRα deficiency conferred resistance viral infection both vivo and vitro. Mechanistically, inhibited production type-I interferon (IFN-I) expression multiple interferon-stimulated genes (ISGs). Furthermore, found induced TBK1-dependent stabilization, which turn associated with...
CD30-directed chimeric antigen receptors (CARs) with single chain antibody fragment (scFv)-binding domains from murine HRS3 show strong cytotoxicity to Hodgkin's Lymphoma cells and have been used in clinical trials. However, scFv CAR might induce specific rejective immune responses patients, which compromises the therapeutic effects. The use of human or humanized fragments for construction, rather than those derived mouse antibodies, can reduce immunogenicity CAR. Importantly, this strategy...
Abstract CD7 has been found to be a promising chimeric antigen receptor (CAR) T cell target in several clinical trials. However, its expression on normal cells poses additional challenges CD7-directed CAR therapy, such as complete fratricide, contamination with malignant cells, and immune suppression due T-cell aplasia. By taking advantage of evolved affinity between ligand receptor, we constructed the extracellular domain SECTM1, natural CD7, recognition domain. SECTM1 killed majority high...
Research has confirmed that extra spindle pole bodies-like 1 (ESPL1), an etiological factor, promotes the malignant progression of cancers. However, relationship between ESPL1 and glioma not yet been demonstrated. The purpose this study was to reveal potential mechanisms ESPL1-mediated progression. Gene expression data detailed clinical information cases were obtained from multiple public databases. Subsequently, a series bioinformatics analyses used elucidate effects on glioma. results...
Abstract Acute liver failure ( ALF ) is associated with high mortality, and a poor understanding of the underlying pathophysiology has resulted in lack effective treatments so far. Here, using an amatoxin‐induced rhesus monkey model , we panoramically revealed cellular molecular events that lead to development . The challenged monkeys toxins underwent typical course including severe hepatic injury, systemic inflammation eventual death. Adaptive immune was not noticeably disturbed throughout...
Abstract Background GINS4 , an indispensable component of the GINS complex, is vital for a variety cancer. However, no known empirical research has focused on exploring relationships between and glioma. Thus, this study aims to understand explain role in Method First, we used data CGGA, TCGA, GEO, GEPIA, HPA databases explore expression level glioma, correlation clinical features its impact survival glioma patients, verified analysis results through RT-qPCR, IHC, meta-analysis. Subsequently,...
Purpose GNG12 influences a variety of tumors; however, its relationship with glioma remains unclear. The aim this study was to comprehensively investigate the between and clinical characteristics prognosis patients reveal mechanisms causing malignant process GNG12. Materials Methods We obtained information on samples from multiple databases. expression level validated using RT-qPCR IHC. KM curves were used assess correlation OS patients. An ROC curve drawn predictive performance Univariate...
Current medical therapies for treating acute myeloid leukemia (AML) remain unmet, and AML patients may benefit from targeted immunotherapy approaches that focus on specific tumor antigens. GRP78, which is upregulated in various malignant tumors such as AML, partially expressed cell surface GRP78 (csGRP78) the membrane, making it an ideal target redirecting T cells, including T-cell engagers. However, considering conventional approach of using two scFv segments to construct a bispecific...
Lung adenocarcinoma (LUAD) is at present the most prevalent subtype of lung cancer worldwide. Non-SMC condensin I complex subunit D2 (NCAPD2) one 3 non-SMC subunits in I. Previous studies have confirmed that NCAPD2 plays a critical role chromosome cohesion and segregation. may be involved tumorigenesis progression by participating abnormal cell cycle division, but prognostic value LUAD remains unclear. We investigated differences expression levels determined their association with clinical...
Calmodulin-binding transcription activator (CAMTA), as one of the factors, is involved in performing important functions modulating plant stress responses and development a Ca2+/CaM-driven modus. However, genome-scale analysis CAMTA has not been systemically investigated roses. Rose (Rosa chinensis Jacq.) gene family members were identified bioinformatically analyzed to investigate their expression characteristics hormonal responses. The results show that total five rose genes identified....
The aim of the present study was to investigate composition, morphology, characteristics, distribution and function distinct macrophage subpopulations in mouse thymus. Apoptosis thymocytes induced by glucocorticoids three monoclonal antibodies against Mac-2, F4/80 ED1 were used for immunofluorescence staining immunohistochemical analysis. morphology thymic macrophages examined transmission electron microscopy. Four identified. Dendritic identified using anti-Mac-2 anti-F4/80 antibodies,...
Elevated Golgi phosphoprotein 2 (GP73, also known as GOLPH2 or GOLM1) expression in serum and liver, which can be induced by viral infection cytokine treatments, is intimately connected with liver disease, including acute hepatitis, cirrhosis hepatocellular carcinoma (HCC). However, its pathogenic roles hepatic diseases have never been clarified detail. Here, we showed that the upregulated GP73 indispensable for SREBPs activation lipogenesis. Notably, overexpression enhanced SCAP-SREBPs...