A5102954180- Inflammasome and immune disorders
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- Inflammatory Biomarkers in Disease Prognosis
- Epigenetics and DNA Methylation
- Reproductive tract infections research
- Drug-Induced Hepatotoxicity and Protection
- Gut microbiota and health
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Inflammation biomarkers and pathways
- Pharmacological Receptor Mechanisms and Effects
- Circular RNAs in diseases
- Cervical Cancer and HPV Research
- Liver Disease and Transplantation
- IL-33, ST2, and ILC Pathways
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2024
Wenzhou Medical University
2023-2024
Jinshan Hospital of Fudan University
2021
Sichuan University
2018
West China Hospital of Sichuan University
2018
Pyroptosis, which is a novel form of immunogenic cell death, plays vital role in antitumor therapy. Zirconium-based metal–organic frameworks (Zr-MOFs) have been applied various treatments. However, the intrinsic these pyroptosis has yet to be determined. Here, Zr-MOF-based nanosystem (DOX@Zr-MOF) was constructed by loading Zr-MOF nanoparticles with chemotherapeutic drug doxorubicin (DOX) synergistically trigger cancer pyroptosis. We found that DOX@Zr-MOF rapidly triggered via activation...
Abstract Acute liver failure ( ALF ) is associated with high mortality, and a poor understanding of the underlying pathophysiology has resulted in lack effective treatments so far. Here, using an amatoxin‐induced rhesus monkey model , we panoramically revealed cellular molecular events that lead to development . The challenged monkeys toxins underwent typical course including severe hepatic injury, systemic inflammation eventual death. Adaptive immune was not noticeably disturbed throughout...
Objective: To assess induction effects of Chlamydia pneumoniae (Cpn) on lung cancer in rats. Methods: A animal model was developed through repeated intratracheal injection Cpn (TW-183) into the lungs rats, with or without exposure to benzo(a)pyrene (Bp). antibodies (Cpn-IgA, -IgG, and -IgM) serum were measured by microimmunofluorescence. Cpn-DNA Cpn-Ag rat detected polymerase chain reaction enzyme-linked immunosorbent assay. Results: The prevalence infection 72.9% (35/48) group 76.7% (33/43)...
Background. N-Acetylcysteine (NAC) had exerted antioxidation and anti-inflammation effects on chronic obstructive pulmonary disease (COPD) patients. However, its effect in regulating interleukin- (IL-) 18 was not fully understood. This study designed to evaluate the specific mechanism of NAC IL-18. Materials Methods. A total 112 COPD patients 103 health individuals were recruited study. Cytokine level patients’ serum measured by enzyme-linked immunosorbent assay (ELISA). mouse model...
Gastric cancer (GC) is one of the most malignant cancers, and cisplatin (Cis)-based chemotherapy remains main clinical treatment for GC. However, Cis resistance often occurs, largely limiting its therapeutic efficacy in tumors. Therefore, a better understanding drug mechanism could reveal new approaches improving GC efficacy. Here, we define integrative role nucleolar coiled-body phosphoprotein 1 (NOLC1), molecular chaperone that significantly upregulated tissues Cis-resistant cells....
Gastric cancer (GC) is one of the most malignant cancers, and cisplatin (Cis)-based chemotherapy remains main clinical treatment for GC. However, Cis resistance often occurs, largely limiting its therapeutic efficacy in tumors. Therefore, a better understanding drug mechanism could reveal new approaches improving GC efficacy. Here, we define integrative role nucleolar coiled-body phosphoprotein 1 (NOLC1), molecular chaperone that significantly upregulated tissues Cis-resistant cells....
Abstract Gastric cancer (GC) is one of the most malignant cancers, and cisplatin (Cis)-based chemotherapy remains main clinical treatment for GC. However, Cis resistance often occurs, largely limiting its therapeutic efficacy in tumors. Therefore, a better understanding drug mechanism could reveal new approaches improving GC efficacy. Here, we define integrative role nucleolar coiled-body phosphoprotein 1 (NOLC1), molecular chaperone that significantly upregulated tissues Cis-resistant...
Pyroptosis, which is a novel form of immunogenic cell death, plays vital role in antitumor therapy. Zirconium-based metal-organic frameworks (Zr-MOFs) have been applied various treatments. However, the intrinsic these pyroptosis remains to be determined. Here, Zr-MOF-based nanosystem (DOX@Zr-MOF) was constructed by loading Zr-MOF nanoparticles with chemotherapeutic drug doxorubicin (DOX) trigger cancer synergistically. We found that DOX@Zr-MOF rapidly triggered via activation canonical...