Schnell mit Nickel: Eine nickelkatalysierte asymmetrische intramolekulare Alkeninsertion der Cyclobutanone 1 reduziert deutlich die Zahl Stufen für Synthese von chiralen Benzobicyclo[2.2.2]octenonen wie 2.

Mesenchymal stem cells (MSCs) derived from adult tissues are an important candidate for cell-based therapies and regenerative medicine due to their multipotential differentiation capability. MSCs have been identified in many but not reported the human intervertebral disc cartilage endplate (CEP). The initial purpose of this study was determine whether exist degenerated CEP. Next, morphology, proliferation capacity, cell cycle, surface epitope profile capacity these CEP-derived (CESCs) were...

The palladium-catalyzed intramolecular C–H arylation reaction of N-(2-bromoaryl)ferrocenecarboxamides furnishes planar chiral ferrocene derivatives. TADDOL-derived phosphoramide ligands induce enantioselectivities ranging from 91:9 to 98:2 er.

Chiral N-heterocyclic carbene (NHC) ligands having a 2,2'-bisquinoline-based C(2) symmetric skeleton were developed. The exhibited good enantioselectivity in palladium-catalyzed intramolecular α-arylation of amides to give 3,3-disubsituted oxindoles.

Abstract Amyloid β -peptide (A ) in its oligomeric form is often considered as the most toxic species Alzheimer’s disease (AD), and thus A oligomer a potentially promising candidate biomarker for AD diagnosis. The development of sensitive reliable method monitoring levels body fluids an urgent requirement order to predict severity progression at early or preclinical stages AD. Here, we show proof concept specific detection oligomers by antibody-aptamer sandwich assay. antibodies...

A simple method for specific colorimetric sensing of Alzheimer's disease related amyloid-β peptide (Aβ) is developed based on the aggregation gold nanoparticles in presence copper ion. The detection limit Aβ(1-40) 0.6 nM and promising results from practical samples (human serum) indicate great potential routine detection.

Abstract To compare outcomes after oblique lateral interbody fusion (OLIF) versus minimally invasive transforaminal lumbar (MISTLIF) with bilateral decompression via unilateral approach for treating mild to moderate symptomatic degenerative spinal stenosis (DLSS). We retrospectively compared patients who underwent single-level (L4/5) OLIF an age-, sex-, and segment-matched MISTLIF cohort. Perioperative data were collected the operative time, intraoperative blood loss, drainage in first...

Abstract Cycloalkanols ring‐opening transformation is one of the most valuable and wide area research. Among numerous methods that have been developed, transition‐metal‐free approaches attracted great interest from both chemists pharmacologists. This largely due to advantages being environmentally benign, cost‐effective operationally simple. Here we provide a comprehensive outline on recent advances in synthesis distally substituted ketones cyclic compounds via cycloalkanols under conditions.

Advancement in tissue engineering provides a promising approach to recover the functionality of degenerated intervertebral disc. In our study, nucleus pulposus (NP) cell-seeded collagen II/hyaluronan/chondroitin-6-sulfate (CII/HyA/CS) tri-copolymer construct was implanted into disc space directly after nucleotomy rabbit model.The aim this study investigate whether NP CII/HyA/CS constructs could regenerate vivo implantation model.Nucleotomy is one most prevalent surgical modalities treat...

In a general view of anatomy, intervertebral disc is composed three parts: annulus fibrosus (AF), nucleus pulposus (NP), and cartilage endplate (CEP). Recently, several types stem cells were successfully isolated from these corresponding regions, but up to now, no research was performed about which kind the most efficient candidate for NP tissue engineering or cell-based regeneration therapy. this study, we compared regenerative potentials above-mentioned kinds disc-derived with that classic...

A Brønsted base and Lewis acid cooperatively catalyzed 1,3-dipolar cycloaddition is reported through chiral dinuclear zinc catalysts. An asymmetric exo′-selective [3 + 2] of CF3-containing N-unprotected isatin-derived azomethine ylides realized. In the presence 10 mol % catalyst, react efficiently with methyleneindolinones, giving a series trifluoromethyl-substituted 2,3-pyrrolidinyl dispirooxindoles highly enantio- (up to 99% ee) exo′-selectivity (>20:1 dr). Up four contiguous stereogenic...

Pd-catalyzed chemo-, regio-, and enantioselective ring-closing/ring-opening cross coupling reaction has been developed with diverse aryl halide-tethered alkenes benzocyclobutenols as substrates, which renders the highly diarylation of unactivated provides a convenient method toward chiral 2,3-dihydrobenzofurans bearing quaternary stereocenter excellent enantioselectivities (up to 98% ee). The application in concise synthesis analogue cannabinoid receptor 2 agonists is described.

In this paper, we have successfully synthesized Zn–chitosan aerogels by freeze drying and further obtained N-doped hierarchically porous carbon (NHPC) through a one-step carbonization process. Zn ions as activators soft templates can efficiently fabricate hierarchical structures in matrix. By adjusting the ratio of zinc–chitosan complexes, structure morphology NHPC be controlled. three-electrode systems, optimal shows superior capacity 230 F g–1 (0.5 A g–1) excellent cycle stability....

Explored the carbonization mechanism of d -calcium pantothenate, including finding optimal carbon skeleton reconstruction, pore structure design, and defect fabrication, constructing stable cathodes with high density long service life.

A copper/cobalt-catalyzed difunctionalization of alkenes with sulfonylazides and tert-butyl hydroperoxide has been achieved. This protocol provides an efficient direct oxysulfonylation approach to β-ketosulfones β-sulfonyl peroxides in moderate good yields under mild conditions. methodology applies as a new sulfonyl radical source features wide substrate scope functional group tolerance.

A novel transition-metal-free cleavage reaction of C–C triple bonds in aromatic alkynes with S8 and amides furnishes aryl thioamides moderate to excellent yields. The remarkable features this thioamidation include the metal-free bond, mild conditions, as well wide substrate scope that is particularly compatible some internal acetamides.

We demonstrated here an efficient synthetic method of carbazole derivatives from readily available N-arylnaphthalen-2-amines and quinone esters catalyzed by Brønsted acid. With this strategy, a series were obtained in good to excellent yields (76 >99) under mild conditions. Large scale reaction illustrated the utility protocol. Meanwhile, C-N axially chiral also constructed moderate (36-89% yield) with atroposelectivities (44-94% ee) using phosphoric acid as catalyst, which provides novel...