A5100398564- Toxoplasma gondii Research Studies
- Herpesvirus Infections and Treatments
- Cytomegalovirus and herpesvirus research
- Immune cells in cancer
- Cancer, Hypoxia, and Metabolism
- Antiplatelet Therapy and Cardiovascular Diseases
- Respiratory Support and Mechanisms
- Atrial Fibrillation Management and Outcomes
- Immune Cell Function and Interaction
- Coronary Interventions and Diagnostics
- Cardiovascular Function and Risk Factors
- Liver Disease Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Acute Myocardial Infarction Research
- Immunotherapy and Immune Responses
- Mesenchymal stem cell research
- Cancer Immunotherapy and Biomarkers
- RNA Interference and Gene Delivery
- Cytokine Signaling Pathways and Interactions
- Aquaculture disease management and microbiota
- Pediatric Hepatobiliary Diseases and Treatments
- Cancer Cells and Metastasis
- Allergic Rhinitis and Sensitization
- Parasitic Infections and Diagnostics
- Pulmonary Hypertension Research and Treatments
Shanghai Institute of Organic Chemistry
2025
University of Chinese Academy of Sciences
2025
Capital Medical University
2021-2025
Hebei Medical University
2023-2025
Decision Sciences (United States)
2025
Cleveland Clinic
2023-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2025
National Taipei University of Business
2025
Peking Union Medical College Hospital
2024-2025
Tongji University
2022-2024
Abstract Macrophage polarization is a highly plastic physiological process that responds to variety of environmental factors by changing macrophage phenotype and function. Tumor-associated macrophages (TAMs) are generally recognized as promoting tumor progression. As universal regulators, microRNAs (miRNAs) functionally involved in numerous critical cellular processes including polarization. Let-7b, miRNA, has differential expression patterns inflamed tissues compared with healthy controls....
Toxoplasma infection causes serious complications in immunocompromised individuals and the developing fetus. During infection, certain immune cells release a protein called interferon gamma that activates to destroy parasite or inhibit its growth.
The subsurface dynamics of dislocations are essential to many properties bulk crystalline materials. However, it is challenging characterize a crystal by conventional transmission electron microscopy (TEM) due the limited penetration depth electrons. A novel X-ray imaging technique – dark-field (DFXM) was developed image hierarchical dislocation structures in crystals. While today's DFXM can effectively map line dislocations, still quantify Burgers vectors, key characterization governing...
Upon invasion of Lewis rat macrophages, Toxoplasma rapidly induces programmed cell death (pyroptosis), which prevents replication, possibly explaining the resistance to Using a chemical mutagenesis screen, we identified mutants that no longer induced pyroptosis. Whole-genome sequencing led identification three parasitophorous vacuole-localized dense granule proteins, GRA35, GRA42, and GRA43, are individually required for induction macrophage Macrophage infection with Δgra35, Δgra42, Δgra43...
Abstract Introduction Pentraxin 3 (PTX3) is an essential regulator of the immune system. However, immune‐modulatory role PTX3 in tumor microenvironment glioma has not been elucidated. Methods The RNA seq samples were obtained from Cancer Genome Atlas (TCGA) and China Glioma (CGGA) datasets. single‐cell sequencing data glioblastoma (GBM) Single Cell Portal platform ( http://singlecell.broadinstitute.org ). Immunohistochemistry was used to assess expression, HAVCR2, PD‐1, PD‐L1, CD276 sections...
Background A large number of observational studies showed that patients with psoriasis have a higher risk cardiovascular disease (CVD), but most did not fully adjust for confounding factors, so it is clear whether the CVD directly attributed to psoriasis. We used Mendelian randomization (MR) evaluate potential causal relationship between and CVD. Methods genetic instruments from genome-wide association study (GWAS) European descent investigate its Inverse variance-weighted (IVW) MR analyses...
Representative hemicellulose, milled wood lignin (MWL), and cellulose were directly separated from corn stalk, their main chemical content was determined using NREL methods. The elements, groups, molecular structure of stalk biomass components (hemicellulose, MWL, cellulose) analyzed by elemental analysis, Fourier transform infrared, nuclear magnetic resonance spectroscopy analyses．The results showed that the purity high, degree damage relatively small, own structural characteristics intact....
The gut damage and microflora disturbance caused by NP intake significantly depended on their surface functional groups.
Toxoplasma gondii is a parasite that replicates within specialized compartment called the parasitophorous vacuole (PV), which surrounded by PV membrane (PVM). To obtain essential nutrients, must transport molecules across PVM, process mediated secreted proteins GRA17 and GRA23. These form pores in PVM through small can diffuse out of PV. GRA23 are synthetically lethal, suggesting at least one pore type for survival. In ‘nutrient sensitized’ Δ gra17 strain it likely other genes become...
To investigate the effect of SUMOylation inhibitor TAK981 on hydrogen peroxide (H2O2)-induced oxidative damage in human retinal pigment epithelial cells (ARPE-19) and its regulatory mechanism. An model ARPE-19 induced by H2O2 was established, 1, 2, 5 µM solutions were administered for intervention respectively. Normal used as control group. The viability each group detected methyl thiazolyl tetrazolium (MTT) method. levels superoxide dismutase (SOD) malondialdehyde (MDA) biochemical methods....
Insulin resistance (IR) is one of the important causes metabolic dysfunction-associated steatotic liver disease (MASLD). Apolipoprotein A-I (apoA-I) secreted primarily by hepatocytes and plays an essential role in reverse cholesterol transport. Our previous studies revealed that apoA-I can mitigate progression steatohepatitis (MASH). However, there no clear evidence to explain relationship between IR. Here, we investigated effects overexpression on IR both HepG2 cells mice. In vitro...
Background: COPD is a heterogeneous disorder. We developed multidisciplinary evaluation scheme to identify patients with who may benefit from phenotype-specific therapy. Methods: Our team of general and interventional pulmonologists, thoracic surgeons, radiologists, respiratory therapists, advanced practice nurses meets monthly discuss COPD. For each patient, pulmonary function tests, imaging, other pertinent data are reviewed. Emphysema assessed visually by quantitative computed tomography...
Objective: The medical terminology escape room game (MTEG) is a chatbot designed for gamified education that aims to transform memorizing complex into an enjoyable experience students. By combining elements of ARCS (Attention, Relevance, Confidence and Satisfaction) theory with adventures, the MTEG enhance students’ learning outcomes by making vocabulary memorization process more immersive. Method: This study involved 48 first-year nursing students, divided experimental group ( n = 24)...