A5103059078- Cancer-related molecular mechanisms research
- Liver physiology and pathology
- Circular RNAs in diseases
- Computational Drug Discovery Methods
- Estrogen and related hormone effects
- MicroRNA in disease regulation
- Recycling and Waste Management Techniques
- Immune cells in cancer
- Extraction and Separation Processes
- Genetic Associations and Epidemiology
- Multi-Criteria Decision Making
- Inflammasome and immune disorders
- Recycled Aggregate Concrete Performance
- Gout, Hyperuricemia, Uric Acid
- Steroid Chemistry and Biochemistry
- Pharmacogenetics and Drug Metabolism
- Extracellular vesicles in disease
- Tryptophan and brain disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Epigenetics and DNA Methylation
- Municipal Solid Waste Management
- Medicinal Plant Pharmacodynamics Research
- Cancer therapeutics and mechanisms
- Systemic Lupus Erythematosus Research
- Hepatocellular Carcinoma Treatment and Prognosis
Shandong University of Traditional Chinese Medicine
2022-2024
Affiliated Hospital of Shandong University of Traditional Chinese Medicine
2022-2024
Jiangxi Provincial Academy of Medical Sciences
2016-2022
Nanchang University
2016-2017
Abstract Macrophage polarization is a highly plastic physiological process that responds to variety of environmental factors by changing macrophage phenotype and function. Tumor-associated macrophages (TAMs) are generally recognized as promoting tumor progression. As universal regulators, microRNAs (miRNAs) functionally involved in numerous critical cellular processes including polarization. Let-7b, miRNA, has differential expression patterns inflamed tissues compared with healthy controls....
Abstract Background Tumor-associated macrophages are considered to be a major contributor affecting the development of tumors. Recently, numerous studies have shown that tumor cells were able educate their microenvironment by delivering significant amount exosomes, however, mechanism exosomes from PCa work in macrophage polarization remains obscure. Therefore, we sought determine whether blockade exosome generation GW4869, an inhibitor biogenesis, would impede differentiating into M2 cells....
Gout is a widespread inflammatory arthritis. The present study aimed to identify potential biomarkers of gout and explore their underlying mechanisms through bioinformatics methods.The microarray data was downloaded from the GSE160170 dataset Gene Expression Omnibus (GEO) database, GEO2R online tool used obtain differentially expressed genes (DEGs). We searched for gout-related DisGeNET GeneCards databases, final DEGs acquired by intersection with obtained dataset. Tissue- organ-specific...
Diabetes retinopathy (DR) is a common microvascular complication of diabetes, and it the main cause global vision loss. The current observational research results show that causal relationship between Vitamin D DR still controversial. Therefore, we conducted Mendelian randomization study to determine potential serum 25-hydroxyvitamin 25(OH)D DR.
The significance of indoleamine 2,3-dioxygenase-1 (IDO1) has been studied in various types tumors, but the relationship between IDO1 and tumor angiogenesis needs further delineation. We aimed to clarify expression, explore possibility IDO1-targeting molecular therapy for lung cancer. For first time, we found that silencing gene using small interfering RNA (siRNA) inhibits vitro cancer cell invasion migration. demonstrated knockdown decreased formation vasculogenic mimicry. In addition these...
To investigate the effects of hydroxycamptothecin (HCPT) on proliferation and apoptosis rat hepatic stellate cells (HSC).Rat HSC line (HSC-T6) hepatocyte (BRL-3A) were treated with different concentrations HCPT (0, 0.008, 0.016, 0.031, 0.125, 0.25, 0.5, 1, 2, 4, 8, 16, 32 mg/L respectively) for 24 h. Cell was assessed by MTT colorimetric assay, detected PI staging followed flow cytometry, DNA ladder assay. The morphological change observed under transmission electron microscopy (TEM).MTT...