A5107459718- SARS-CoV-2 and COVID-19 Research
- Viral gastroenteritis research and epidemiology
- Monoclonal and Polyclonal Antibodies Research
- Animal Virus Infections Studies
- Recycling and utilization of industrial and municipal waste in materials production
- Concrete and Cement Materials Research
- Additive Manufacturing Materials and Processes
- Erythrocyte Function and Pathophysiology
- Microbial Community Ecology and Physiology
- Technology Assessment and Management
- Image Processing Techniques and Applications
- Bacteriophages and microbial interactions
- Wastewater Treatment and Nitrogen Removal
- SARS-CoV-2 detection and testing
- Diverse Aspects of Tourism Research
- Polymer composites and self-healing
- Polydiacetylene-based materials and applications
- Hemoglobinopathies and Related Disorders
- nanoparticles nucleation surface interactions
- Sport and Mega-Event Impacts
- Additive Manufacturing and 3D Printing Technologies
- Viral Infections and Immunology Research
- Conducting polymers and applications
- Microbial Fuel Cells and Bioremediation
- Image Retrieval and Classification Techniques
Peking Union Medical College Hospital
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
ShanghaiTech University
2023-2025
Ministry of Agriculture and Rural Affairs
2024
Shanghai Ocean University
2024
Shanghai Academy of Agricultural Sciences
2024
Anhui University of Technology
2024
First Affiliated Hospital of Guangzhou Medical University
2024
State Key Laboratory of Respiratory Disease
2024
Guangzhou Medical University
2024
Omicron, as the emerging variant with enhanced vaccine tolerance, has sharply disrupted most therapeutic antibodies. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) belongs to subgenus Sarbecovirus, members of which share high sequence similarity. Herein, we report one sarbecovirus antibody, 5817, broad-spectrum neutralization capacity against SARS-CoV-2 variants concern (VOCs) and SARS-CoV, well related bat pangolin viruses. 5817 can hardly compete six classes...
Neutralizing antibody titers have been shown to correlate with immune protection against COVID-19 and can be used estimate vaccine effectiveness. Numerous studies explored the relationship between neutralizing antibodies protection. However, there remains a lack of quantitative data directly assessing minimum effective protective titer in vivo. In this study, we utilized eight cohorts participants diverse backgrounds for evaluation response. To precisely assess lower threshold required...
Abstract Plasma cell disorders (PCDs) are marked by the clonal proliferation of abnormal plasma cells and bone marrow (BMPCs), causing various clinical complications. These PCDs include subtypes with distinct features. Multiple myeloma (MM) monoclonal gammopathy undetermined significance (MGUS) more common relatively well-studied. In contrast, primary light-chain amyloidosis (AL) POEMS syndrome (POEMS) rare remain less understood. To investigate role hematopoietic (CH) mutations potential...
Abstract The Omicron subvariants BQ.1.1, XBB.1.5, and XBB.1.16 of SARS-CoV-2 are known for their adeptness at evading immune responses. Here, we isolate a neutralizing antibody, 7F3, with the capacity to neutralize all tested variants, including XBB.1.16. 7F3 targets receptor-binding motif (RBM) region exhibits broad binding panel 37 RBD mutant proteins. We develop IgG-like bispecific antibody G7-Fc using cross-neutralizing GW01. demonstrates robust activity against 28 variants...
SARS-CoV-2 viruses are highly transmissible and immune evasive. It is critical to develop broad-spectrum prophylactic therapeutic antibodies for potential future pandemics. Here, we used the phage display method discover nanobodies (Nbs) neutralizing especially Omicron strains. The leading nanobody (Nb), namely, Nb4, with excellent physicochemical properties, can neutralize Delta subtypes, including BA.1, BA.1.1 (BA.1 + R346K), BA.2, BA.5, BQ.1, XBB.1. crystal structure of Nb4 in complex...
The Internet has been developed so far, computer rapidly, and the use of for image processing widely used in all walks life, MATLAB become a hot topic today. Image can find information it wants many images repeatedly compressed on network, restore to certain extent. Edge step is included various digital models. So particularly important processing. Common edge detection algorithms include Prewitt, Sobel, Canny, on. Choosing more appropriate effective operator becomes image. three operators...
Abstract Research on virus/receptor interactions has uncovered various mechanisms of antibody‐mediated neutralization against severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). However, understanding by antibodies targeting the silent face, which recognize epitopes glycan shields, remains limited, and their potential protective efficacy in vivo is not well understood. This study describes a face neutralizing antibody, 3711, targets non‐supersite N‐terminal domain (NTD) spike...
This paper applies machine learning and text analysis to the operation of historical culture scenic spots verify effectiveness universality application analysis. We use random forest algorithm binary logistic regression method analyze predict experience perception revisit willingness spots, find out important factors that affect tourists' willingness, explore concerns tourist attractions through term frequency semantic networks Based on results data mining, propose strategies improve cultural spots.
There is significant controversy in the academic and judicial practice regarding determination of trademark infringement foreign-related Original Equipment Manufacture (OEM) industry, so it necessary to construct a basic judgment path. On basis clarifying debate about OEM trademark, further analysis conducted on positioning "trademark use" infringement, conclusion can be drawn that "possibility confusion" substantive element for determining infringement. Finally, by defining scope relevant...