A5079743639- Platelet Disorders and Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Kruppel-like factors research
- Hemophilia Treatment and Research
- Blood groups and transfusion
- Chronic Myeloid Leukemia Treatments
- Acute Myeloid Leukemia Research
- Eosinophilic Disorders and Syndromes
- Chronic Lymphocytic Leukemia Research
- Autoimmune Bullous Skin Diseases
- Blood properties and coagulation
- Telomeres, Telomerase, and Senescence
- Epigenetics and DNA Methylation
- Blood Coagulation and Thrombosis Mechanisms
- Cell Adhesion Molecules Research
- Mesenchymal stem cell research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Immunodeficiency and Autoimmune Disorders
- Dietary Effects on Health
- Lipid metabolism and disorders
- Mycotoxins in Agriculture and Food
- Plant Pathogens and Fungal Diseases
- RNA modifications and cancer
- Periodontal Regeneration and Treatments
- Parvovirus B19 Infection Studies
Institute of Hematology & Blood Diseases Hospital
2017-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2025
Huazhong Agricultural University
2024
National Clinical Research
2023
Peking Union Medical College Hospital
2023
Patients with refractory immune thrombocytopenia (ITP) frequently encounter substantial bleeding risks and demonstrate limited responsiveness to existing therapies. Umbilical cord-derived mesenchymal stem cells (UC-MSCs) present a promising alternative, capitalizing on their low immunogenicity potent immunomodulatory effects for treating diverse autoimmune disorders. This prospective phase I trial enrolled eighteen eligible patients explore the safety efficacy of UC-MSCs in ITP. The research...
Immune thrombocytopenia (ITP) is an autoimmune disease characterized by autoantibody-mediated platelet destruction. Treatment with CM313, a novel anti-CD38 monoclonal antibody, can result in targeted clearance of CD38-positive cells, including plasma cells.
The implications of stem cell heterogeneity for disease pathogenesis and therapy are poorly defined. JAK2V617F+ myeloproliferative neoplasms (MPNs), harboring the same mutation in hematopoietic cells (HSCs), display diverse phenotypes, including polycythemia vera (PV), essential thrombocythemia (ET), primary myelofibrosis (PMF). These chronic malignant disorders ideal models to analyze pathological consequences heterogeneity. Single-cell gene expression profiling with parallel detection...
<title>Abstract</title> Building on promising phase 1 pilot results demonstrating safety and efficacy of BBM-H901 (AAV-mediated FIX Padua gene therapy) in restoring factor IX activity (FIX:C) among 10 patients with haemophilia B, we conducted current studies to verify its larger Chinese B patients. A multicentre, single-arm, open-label study (phase 1/2: dose-escalation, n = 6; 3: fixed-dose, 26) a long- term study(n 10) were conducted. Eligible participants received 5×10¹² vg/kg...
Abstract Acquired hemophilia A (AHA) is a rare but serious bleeding disorder. Randomized controlled trial (RCT) comparing the efficacy of immunosuppression therapy for AHA lacks. We conducted first multicenter RCT aiming to establish whether single‐dose rituximab combination regimen was noninferior cyclophosphamide regimen. From 2017 2022, 63 patients with newly diagnosed from five centers were randomly assigned 1:1 receive glucocorticoid (methylprednisolone 0.8 mg/kg per day 3 weeks and...
Bleeding episodes in hemophiliacs with inhibitors are difficult to control. Staidson protein-0601 (STSP-0601), a specific factor (F)X activator purified from the venom of Daboia russelii siamensis, has been developed.We aimed investigate efficacy and safety STSP-0601 preclinical clinical studies.In vitro vivo studies were performed. A phase 1, first-in-human, multicenter, open-label trial was conducted. The study divided into parts B. Hemophiliacs eligible for this study. Patients received...
Immune thrombocytopenia (ITP) is an autoimmune disease characterized by antibody-mediated platelet destruction and impaired production. The mechanisms underlying ITP biomarkers predicting the response of drug treatments are elusive. We performed a metabolomic profiling bone marrow biopsy samples collected from patients admission in prospective study National Longitudinal Cohort Hematological Diseases. Machine learning algorithms were conducted to discover novel predict patient treatment...
This study aimed to identify key proteomic analytes correlated with response splenectomy in primary immune thrombocytopenia (ITP). Thirty-four patients were retrospectively collected the training cohort and 26 prospectively enrolled as validation cohort. Bone marrow biopsy samples of all participants prior splenectomy. A total 12 modules proteins identified by weighted gene co-expression network analysis (WGCNA) method developed The tan module positively megakaryocyte counts before (r =...
To the Editor: Male sex has been confirmed to be an independent risk factor for survival in patients with essential thrombocythemia (ET).[1,2] Sexual dimorphism significantly contributes patient heterogeneity, and adopting a sex-informed perspective emerged as pioneering paradigm field of precision medicine. Investigating spectrum disparities among diagnosed ET holds substantial scientific justification. Furthermore, influences presentation, disease phenotypes, symptom expression, clinical...
The role of the bone marrow niche in essential thrombocythemia (ET) remains unclear. Here, we observed multilevel defects hematopoietic patients with JAK2V617F-positive ET, including functional deficiency mesenchymal stromal cells (MSC), immune imbalance, and sympathetic-nerve damage. Mesenchymal from had a transformed transcriptome. In parallel, they showed enhanced proliferation, decreased apoptosis senescence, attenuated ability to differentiate into adipocytes osteocytes, insufficient...
Essential thrombocythemia (ET) is characterized by thrombotic and hemorrhagic events. The association of clinical characteristics Chinese ET patients additional sex combs like 1 (ASXL1) mutations in these has remained to be elucidated. In the present study, 72 newly diagnosed were enrolled determine ASXL1 mutations. Mutations ASXL1, Janus kinase (JAK)2, calreticulin (CALR) myeloproliferative leukemia (MPL) genes detected using Sanger sequencing, data statistically analyzed. frequencies JAK2...
Abstract The causal direction and extent of the link between telomere length, epigenetic age acceleration (EAA), occurrence haematological malignancies benign disorders remain uncertain because inherent susceptibility observational studies to confounding reverse causation. We conducted two-sample single-variable Mendelian randomisation (SVMR) multivariable (MVMR) analyses using summary statistics from genome-wide association (GWAS) explore potential associations among EAA, multiple...