A5013182108- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Platelet Disorders and Treatments
- Lipid metabolism and disorders
- Kruppel-like factors research
- Hemophilia Treatment and Research
- Cytokine Signaling Pathways and Interactions
- Glutathione Transferases and Polymorphisms
- Sphingolipid Metabolism and Signaling
- Blood properties and coagulation
- Angiogenesis and VEGF in Cancer
- Eosinophilic Disorders and Syndromes
- Renin-Angiotensin System Studies
- Pharmacogenetics and Drug Metabolism
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Hemostasis and retained surgical items
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Blood groups and transfusion
- Blood Coagulation and Thrombosis Mechanisms
- Cancer, Hypoxia, and Metabolism
Institute of Hematology & Blood Diseases Hospital
2023-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2024
Chinese Academy of Agricultural Sciences
2024
Institute of Plant Protection
2024
First Affiliated Hospital of Zhengzhou University
2021
Central Hospital of Zibo
2010
Immune thrombocytopenia (ITP) is an autoimmune disease characterized by antibody-mediated platelet destruction and impaired production. The mechanisms underlying ITP biomarkers predicting the response of drug treatments are elusive. We performed a metabolomic profiling bone marrow biopsy samples collected from patients admission in prospective study National Longitudinal Cohort Hematological Diseases. Machine learning algorithms were conducted to discover novel predict patient treatment...
<p>Supplementary Figure S2. Platelet CD62P expression and phosphatidylserine exposure of TN-ET platelets after ROS inhibition.</p>
Abstract Epidemiological and experimental evidence has linked chronic inflammation to the etiology of myeloproliferative neoplasm (MPN). However, it remains unclear whether genetic associations with specific inflammatory biomarkers are causal or due bias. This study aimed assess effect C-reactive protein (CRP) systemic regulators on MPN within a bidirectional Mendelian randomization design. Genetic were derived from publicly available genome-wide association (GWAS) comprising 1,086 cases...
Essentials•Isolated acquired clotting factor deficiencies (ACFDs) other than hemophilia A are rare.•Clinical features of 54 isolated ACFD patients at a single center were retrospectively analyzed.•Twenty-two (61.9%) achieved complete remission.•Isolated ACFDs underestimated, associated with delayed diagnosis, and lack effective therapy.AbstractBackgroundIsolated mainly caused by the existence anti-factor antibodies or adsorption factors onto substances such as amyloid. Besides (F)VIII...
Abstract Purpose: Triple-negative (TN) essential thrombocytopenia (ET) is characterized by the absence of driver mutations while retaining histological and phenotypic characteristics sufficient for an ET diagnosis. Our understanding TN-ET its platelet activation remains incomplete. We carried out a large-scale multi-center clinical analysis to analyze molecular characteristics, thrombotic complications TN-ET. also related above further explore thrombosis mechanism Experimental Design:A...
<div>AbstractPurpose:<p>Triple-negative (TN) essential thrombocytopenia (ET) is characterized by the absence of driver mutations while retaining histologic and phenotypic characteristics sufficient for an ET diagnosis. Our understanding TN-ET its platelet activation remains incomplete. We carried out a large-scale multicenter clinical analysis to analyze molecular thrombotic complications TN-ET. also related above further explore thrombosis mechanism TN-ET.</p>Experimental...
<p>Supplementary Figure S1. Platelet CD62P expression in JAK2V617F-positive ET patients and TN-ET of different age groups.</p>
Abstract Background Clinical prediction models to classify lung nodules often exclude patients with mediastinal/hilar lymphadenopathy, although the presence of lymphadenopathy does not always indicate malignancy. Herein, we developed and validated a multimodal model for in which were included. Methods A total 359 pulmonary considered enrollment study. We logistic regression including lymphadenopathy. Discrimination was assessed by area under operating curve. Goodness fit performed via...