A5103143678- Bone Tissue Engineering Materials
- Nanoplatforms for cancer theranostics
- Advanced ceramic materials synthesis
- Extracellular vesicles in disease
- Electrospun Nanofibers in Biomedical Applications
- Catalytic Processes in Materials Science
- Spine and Intervertebral Disc Pathology
- Hip and Femur Fractures
- Orthopaedic implants and arthroplasty
- Shoulder and Clavicle Injuries
- Graphene and Nanomaterials Applications
- Orthopedic Surgery and Rehabilitation
- Osteoarthritis Treatment and Mechanisms
- Bone fractures and treatments
- Calcium Carbonate Crystallization and Inhibition
- Foot and Ankle Surgery
- Hip disorders and treatments
- Dental Implant Techniques and Outcomes
- 3D Printing in Biomedical Research
- Advanced Nanomaterials in Catalysis
- MicroRNA in disease regulation
- Shoulder Injury and Treatment
- Nanoparticle-Based Drug Delivery
- Influenza Virus Research Studies
- Aluminum Alloys Composites Properties
Shanghai University
2020-2025
Shanghai University of Medicine and Health Sciences
2015-2024
Dalian Jiaotong University
2011-2024
Hebei University of Engineering
2021-2024
Beijing Institute of Technology
2024
Yan'an University
2023-2024
Chinese Academy of Agricultural Sciences
2024
Institute of Plant Protection
2024
Huawei Technologies (China)
2023
Beijing Institute of Petrochemical Technology
2022
The differentiation shift from osteogenesis to adipogenesis of bone marrow mesenchymal stem cells (BMSCs) characterizes many pathological loss conditions. Stromal cell-derived factor-1 (SDF1) is highly enriched in the for C-X-C motif chemokine receptor 4 (CXCR4)-positive hematopoietic cell (HSC) homing and tumor metastasis. In this study, we displayed CXCR4 on surface exosomes derived genetically engineered NIH-3T3 cells. CXCR4+ selectively accumulated marrow. Then, fused with liposomes...
Abstract 3D‐printed polycaprolactone (PCL) scaffolds have been extensively studied for application in bone tissue engineering. However, PCL‐based with enhanced bioactivity and intelligent delivery capability repair remains challenging. Herein, CuS nanoparticle‐PEG soft hydrogel‐coated 3D hard (denoted as CuS‐PEG‐PCL scaffold) are rationally designed efficient regeneration. nanoparticles cross‐linked PEG hydrogel (CuS‐PEG‐hydrogel) endows the scaffold excellent photothermal properties stable...
Osteoarthritis (OA) is a common joint disease known for cartilage degeneration, leading to substantial burden on individuals and society due its high disability rate. However, current clinical treatments defects remain unsatisfactory the unclear mechanisms underlying regeneration. Tissue engineering hydrogels have emerged as an attractive approach in repair. Recent research studies indicated that stem cells can sense mechanical strength of hydrogels, thereby regulating their differentiation...
Segmental bone defects, stemming from trauma, infection, and tumors, pose formidable clinical challenges. Traditional repair materials, such as autologous allogeneic grafts, grapple with limitations including source scarcity immune rejection risks. The advent of nucleic acid nanotechnology, particularly the use DNA hydrogels in tissue engineering, presents a promising solution, attributed to their biocompatibility, biodegradability, programmability. However, these hydrogels, typically...
Intervertebral disc degeneration (IDD) has been considered as the primary pathological mechanism that underlies low back pain. Understanding molecular mechanisms underlying human IDD is imperative for making strategies to treat IDD-related diseases. Herein, we report programs, lineage progression patterns, and paths of cellular communications during using single-cell RNA sequencing (scRNA-seq) on nucleus pulposus (NP) cells from patients with different grades undergoing discectomy. New...
Cartilage defects are usually caused by acute trauma and chronic degeneration. However, it is still a great challenge to improve the repair of articular cartilage due limited self-regeneration capacity such defects. Herein, novel ROS-responsive in situ nanocomposite hydrogel loaded with kartogenin (KGN) bone marrow-derived stem cells (BMSCs) was designed constructed via enzymatic reaction fibrinogen thrombin. Meanwhile, thioketal (TK)-based liposome synthesized load chondrogenesis-inducing...
Control over the morphology and chemical composition of hydroxyapatite (HAp) bioceramic scaffolds is great importance for their applications. In present study, Si-substituted HAp with controllable morphologies (nanosheets nanorods) were fabricated via hydrothermal treatment calcium silicate as precursors in NaH2PO4 Na3PO4 aqueous solutions, respectively. Moreover, effects surface Si substitution on cell attachment, proliferation, osteogenic differentiation rat bone marrow stromal cells...
The construction of a nanoimmune controlled-release system that spatiotemporally recognizes tumor lesions and stimulates the immune response step by is one most potent cancer treatment strategies for improving sensitivity immunotherapy response.Here, composite nanostimulator (CNS) was constructed release second near-infrared (NIR-II) photothermal-mediated agents, thereby achieving controllable photothermal-synergized immunotherapy. CNS nanoparticles comprise thermosensitive liposomes as an...
Interconnected collagen porous scaffolds were prepared using PLGA sponges as sacrificial templates and applied for cartilage tissue engineering.
Infrared neural stimulation with the assistance of photothermal transducers holds great promise as a mini-invasive modulation modality. Optical nanoparticles absorption in near-infrared (NIR) window have emerged excellent due to their good biocompatibility, surface modifiability, and tunable optical absorption. However, poor activation efficiency limited depth are main predicaments encountered mediated by these nanoparticles. In this study, we prepared targeted polydopamine (PDA)-coated gold...